Medicament for treating type II diabetic cardiopathy and preparation method thereof

A technology for type 2 diabetes and heart disease, applied in the field of medicine, to achieve rapid and reliable curative effect, increase NOS content, and lower blood sugar

Inactive Publication Date: 2012-03-14
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine has shown certain curative effect in the prevention and treatment of diabetic vascular disease, but there is no Chinese patent medicine related to the prevention and treatment of diabetic heart disease in China.

Method used

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  • Medicament for treating type II diabetic cardiopathy and preparation method thereof
  • Medicament for treating type II diabetic cardiopathy and preparation method thereof
  • Medicament for treating type II diabetic cardiopathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, the medicine for the treatment of type 2 diabetic heart disease of the present invention and its preparation

[0020] One, pharmaceutically active components and the dosage of pharmaceutically active components (parts by weight):

[0021] Astragalus 645g

[0022] Schisandra 215g

[0023] Wujia skin 130g

[0024] Citrus aurantium 215g

[0025] Pseudostellaria 215g

[0026] Leech 215g.

[0027] Two, the preparation method is as follows:

[0028] Get 215g leeches and grind them into fine powder; get 215g schisandra chinensis, 130g Wujiapi, 215g citrus citrus three herbs and add 80% ethanol for reflux extraction 3 times, each time for 2 hours, combine the extracts, reclaim ethanol, and concentrate to a relative density of 1.35( 80 ℃) thick ointment; the dregs of the above three medicines, 645g Astragalus root, 215g Radix Pseudostellaria Pseudostellariae and two herbal medicines were decocted in water for 3 times, each time for 2 hours, the decoction was ...

Embodiment 2

[0029] Embodiment 2, the preparation of the medicine of the present invention treatment type 2 diabetic heart disease

[0030] One, pharmaceutically active components and the dosage of pharmaceutically active components (parts by weight):

[0031] Astragalus 500g

[0032] Schisandra 150g

[0033] Wujia Peel 50g

[0034] Citrus aurantium 150g

[0035] Pseudostellaria ginseng 150g

[0036] Leeches 150g

[0037] Two, the preparation method is as follows:

[0038] Get the leeches of the prescribed amount and crush them into fine powder; get the schisandra chinensis, Wujiapi, and Fructus Citrus Citrus Fructus of the prescribed amount and add 80% ethanol to reflux and extract 4 times, each time for 3 hours, combine the extracts, reclaim the ethanol, and concentrate to a relative density of 1.55 (80 ℃) thick ointment; the dregs of the above three medicines and the prescribed amount of Astragalus membranaceus and Pseudostellaria heterophylla are decocted with water for 4 times, ...

Embodiment 3

[0039] Embodiment 3, the medicine of the present invention for treating type 2 diabetes mellitus heart disease and its preparation

[0040] One, pharmaceutically active components and the dosage of pharmaceutically active components (parts by weight):

[0041] Astragalus 800g

[0042] Schisandra 250g

[0043] Wujia skin 150g

[0044] Citrus aurantium 250g

[0045] Pseudostellaria ginseng 250g

[0046] Leeches 250g

[0047] Two, the preparation method is as follows:

[0048]Take the leeches of the prescribed quantity and crush them into fine powder; take the schisandra chinensis, Wujiapi, and Citrus aurantii three herbs of the prescribed quantity and add 60% ethanol to reflux and extract twice, each time for 1 hour, combine the extracts, reclaim the ethanol, and concentrate to a relative density of 1.15 (80 ℃) thick ointment; the dregs of the above three medicines and the prescribed amount of Astragalus and Radix Pseudostellariae are decocted twice, each time for 1 hour, ...

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Abstract

The invention discloses a medicament for treating type II diabetic cardiopathy and preparation thereof. The medicament is mainly prepared from the following raw materials in part by weight: 50 to 80 parts of astragalus, 15 to 25 parts of leech and 15 to 25 parts of immature bitter orange, and is preferably prepared from the following raw materials in part by weight: 64.5 parts of astragalus, 21.5parts of leech, 21.5 parts of immature bitter orange, 21.5 parts of Chinese magnoliavine fruit, 21.5 parts of heterophylly falsestarwort root and 13 parts of cortex acanthopanacis. The medicament is any pharmaceutical formulation, preferably capsules. Animal experiments prove that the medicament has the effects of reducing animal model blood sugar, correcting turbulence of lipid metabolism, improving hemarheology, adjusting the ratio of 6-KETO to TXB2, increasing NOS content, promoting NO secretion synthesis to increase and particularly improving the ST change of an acute myocardial ischaemiaanimal model. Therefore, the medicament of the invention can prevent or treat the type II diabetic cardiopathy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for treating type 2 diabetic heart disease and a preparation method thereof. Background technique [0002] Diabetic heart disease refers to a chronic vascular complication of diabetes, involving the large, medium, small and micro blood vessels of the heart. It is characterized by young age of onset, rapid progression, high morbidity and mortality, and high susceptibility to arrhythmia, heart failure, and sudden death. It is the most life-threatening disease among the various complications of diabetes. Diabetic patients with coronary heart disease are 2-4.5 times that of non-diabetic patients. The average medical history of diabetic patients is 6.5 years, the incidence of coronary heart disease is 12%, and the mortality rate of diabetic myocardial infarction is twice that of non-diabetic patients. Diabetics combined with cardiac insufficiency are 4 times that of non-d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P3/10A61K35/62
Inventor 林兰
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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