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Peony extract-methotrexate composition, preparation method thereof and use thereof

A technology of methotrexate and extracts, applied in the field of medicine, can solve problems such as adverse reactions and unsatisfactory curative effects, and achieve the effect of avoiding liver damage and taking medicine conveniently

Inactive Publication Date: 2010-12-29
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its curative effect is still unsatisfactory, and there are still some adverse reactions.

Method used

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  • Peony extract-methotrexate composition, preparation method thereof and use thereof
  • Peony extract-methotrexate composition, preparation method thereof and use thereof
  • Peony extract-methotrexate composition, preparation method thereof and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 500g of peony extract with 50% paeoniflorin content, 1g of methotrexate, first saturate the equipment used for mixing with a small amount of peony extract, pour it out, add methotrexate, first take 1g of peony extract, grind and mix evenly, Then add 2g of peony extract and mix well, then add 4g of peony extract and mix well, then add 8g of peony extract and mix well, then add 16g of peony extract and mix well, then add 32g of peony extract and mix well, then add 64g of peony extract and then add 128g of herbaceous peony extract and mix evenly, then add the remaining 245g of herba peony extract and mix evenly to obtain the composition of the present invention.

Embodiment 2

[0024] Take 100 g of the paeoniae officinalis extract methotrexate composition prepared in Example 1, and directly pack it into a No. 0 hollow hard capsule to prepare capsules, each containing about 0.4 g, to obtain the composition extension preparation capsule of the present invention.

Embodiment 3

[0026] Get 400g of the peony extract methotrexate composition prepared in Example 1, prepare the composition granules by dry granulation, pass through a 24-mesh standard sieve, and directly pack into No. 0 hollow hard capsules to obtain capsules, each containing about 0.4 g to obtain the composition extension preparation capsule of the present invention.

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PUM

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Abstract

The invention provides a peony extract-methotrexate composition, a preparation method thereof and use thereof. The peony extract-methotrexate composition is prepared from a peony extract and methotrexate and has a better rheumatoid treatment effect than methotrexate and the mixture of the methotrexate and total glucosides of paeony. Meanwhile, the composition can reduce or avoid adverse reactions caused by the methotrexate, such as liver damage, somnolence, inappetence and the like.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a peony extract methotrexate composition, a preparation method of the peony extract methotrexate composition and an application thereof. Background technique [0002] Rheumatoid arthritis is a systemic rheumatic disease that mainly affects the joints. All have higher morbidity rate and severe disability rate in all races of the crowd, and have great harm to human beings. [0003] At present, the clinical drugs for rheumatoid arthritis mainly include non-steroidal anti-inflammatory drugs, slow-acting anti-rheumatic drugs and biological agents, etc. These drugs have played an important role in clinical treatment. However, long-term use of non-steroidal anti-inflammatory drugs has many adverse reactions. Long-term use of slow-acting anti-rheumatic drugs can cause serious adverse reactions to important organs and tissues. Biological agents often have serious adverse reactions that ...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P29/00A61P19/02A61P19/04A61K31/519
Inventor 周海滨江海龙杨海玲张新明
Owner NINGBO LIWAH PHARM CO LTD
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