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Analgesic and anti-inflammatory medicament and preparation method thereof

A drug and composition technology, applied in the field of traditional Chinese medicine and the preparation of the drug, can solve the problems of damage to the hematopoietic system and gastric mucosa, side effects cannot be underestimated, renal insufficiency, etc., to reduce the number of writhing reactions, clear prescriptions, increase pain threshold effect

Active Publication Date: 2012-05-02
于明希
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the western medicines for this kind of diseases are effective quickly, the side effects should not be underestimated.
Long-term use will cause harm to the body, can cause allergic reactions, damage the hematopoietic system and gastric mucosa, and lead to serious consequences such as renal insufficiency

Method used

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  • Analgesic and anti-inflammatory medicament and preparation method thereof
  • Analgesic and anti-inflammatory medicament and preparation method thereof
  • Analgesic and anti-inflammatory medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1, prepare the tablet of two flavors Chinese medicine composition

[0032] Take 100g rhubarb and 100g gardenia medicinal materials, clean slices or segments, and reflux extract the above medicinal materials with 85% ethanol aqueous solution for 3 times, the quality of the first extraction solvent is 6 times that of the medicinal materials. times, extraction for 2 hours, the quality of the second extraction solvent is 6 times of the quality of the medicinal material, extraction for 2 hours, the quality of the third extraction solvent is 5 times of the quality of the medicinal material, extraction for 1 hour, each extraction is completed Afterwards, filter, collect the filtrate, combine the three filtrates, and reclaim ethanol, concentrate the filtrate at 70° C. into a thick paste with a relative density of 1.20 to 1.30, dry and pulverize to obtain a pharmaceutical composition powder (through a 100-mesh sieve), add Appropriate amount of auxiliary materials such...

Embodiment 2

[0033] Embodiment 2, prepare the capsule of two flavors Chinese medicine composition

[0034] Take 20g rhubarb and 100g gardenia medicinal materials, clean slices or segments, and reflux extract the above medicinal materials once with water. The quality of the extraction solvent is 8 times the mass of the medicinal materials. Extract for 3.5 hours. After the extraction is completed, filter. Collect the filtrate, concentrate the filtrate at 70°C into a thick paste with a relative density of 1.20 to 1.30, dry and pulverize to obtain a pharmaceutical composition powder (through a 100-mesh sieve), add appropriate amount of starch and other auxiliary materials, mix well, granulate, pack into In the capsule shell, it is made into capsules.

Embodiment 3

[0035] Embodiment 3, prepare the capsule of two flavors Chinese medicine composition

[0036] Take 100g of rhubarb and 60g of gardenia medicinal materials, clean slices or segments, extract the above medicinal materials with water for 3 times, the quality of the first extraction solvent is 8 times the mass of the medicinal materials, extract for 2 hours, and the second extraction solvent The quality of the solvent is 5 times of the quality of the medicinal material, extracted for 1 hour, the quality of the third extraction solvent is 5 times of the quality of the medicinal material, extracted for 1 hour, after each extraction, filter, collect the filtrate, and combine the filtrate three times , the filtrate is concentrated into an extract with a relative density of 1.10 to 1.20, then ethanol is added to the extract to make the alcohol content in the mixed system 50%, put in a closed container, stand still for 24 hours, filter to obtain the filtrate, reclaim the ethanol, Concen...

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Abstract

The invention discloses a medicinal composition with effects of relieving pain, resisting inflammation, activating blood and dissolving stasis and a preparation method and application thereof. The medicinal composition is prepared from the following raw materials in part by weight: 20 to 100 parts of rhubarb and 20 to 100 parts of gardenia. In order to better perfect the compatibility of medicaments, the medicinal composition also can comprise the following raw materials in part by mass: 20 to 100 parts of rhubarb, 20 to 100 parts of gardenia, 10 to 30 parts of common monkshood mother root, 10 to 30 parts of kusnezoff monkshood root, 20 to 80 parts of divaricate saposhnikovia root, 20 to 80 parts of incised notopterygium rhizome, 30 to 70 parts of Chinese angelica and 30 to 70 parts of szechuan lovage rhizome. Animal experiments prove that the medicinal composition can obviously reduce various hemorheological indexes of a qi-stagnation blood-stasis model rat, has the effects of promoting qi and blood circulation, can increase pain threshold of the rat and reduce the writhing response times of the rat, has obvious analgesic effect, can inhibit ear swelling of the rat caused by dimethyl benzene and has obvious anti-inflammatory and anti-swelling effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and a preparation method of the medicine, in particular to a medicine with analgesic, anti-inflammation and promoting blood circulation and removing blood stasis effects and a preparation method thereof. Background technique [0002] Osteoarthritis, rheumatic pain, neck, shoulder, waist, and leg joint pain, neuropathic pain, bruises, etc. are common and frequently-occurring diseases, which seriously affect people's work, study and daily life. Although western medicine for treating such diseases takes effect quickly, its side effects cannot be underestimated. Long-term use will cause harm to the body, can cause allergic reactions, damage the hematopoietic system and gastric mucosa, and lead to serious consequences such as renal insufficiency. [0003] Traditional Chinese medicine treatment of diseases is generally based on the principle of seeking the root of the disease. It has the advantages of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61P29/00
Inventor 于春江
Owner 于明希
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