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Method for determining the hepatic properties of an organism by means of quantitative measurements of the metabolism of substrates

A technology of metabolites and substrates, applied in the field of raw data, can solve the problems of offsetting individual quantitative determination, impossibility, and no change

Active Publication Date: 2015-07-29
HUMEDICS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] 5.) Metabolic processes do not vary from person to person in their reaction efficiency, as this would negate the quantitative determination of the individual
[0016] The points detailed are not possible to achieve by means of hitherto known methods

Method used

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  • Method for determining the hepatic properties of an organism by means of quantitative measurements of the metabolism of substrates
  • Method for determining the hepatic properties of an organism by means of quantitative measurements of the metabolism of substrates
  • Method for determining the hepatic properties of an organism by means of quantitative measurements of the metabolism of substrates

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Embodiment Construction

[0072] In a preferred implementation form of the current method, according to figure 2 Determination of human liver performance is performed in the diagram shown. In the measurement procedure, through the substrate to be metabolized, especially 13 C Methacetin 1 combined with intravenous administration of saline solution 1a to initiate metabolism.

[0073] Administration of substrate intravenously ensures rapid substrate flooding and rapid initiation of substrate metabolism required for assessment. Here, the initiation of substrate metabolism by enzymatic turnover of substrates in the liver is faster than the respiratory rhythm.

[0074] exist Figure 6 The transport of the administered substrate to the liver and the conversion or breakdown of the substrate and the conversion or breakdown that takes place there are schematically shown in . For example 13 The administered substrate of C methacetin (double-hatched circle) is transported with specific transport constants in...

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Abstract

A method for determining the liver performance of a living organism, in particular a human, comprising administering at least one 13C labelled substrate, which is converted by the liver by releasing at least one 13C labelled metabolization product, and determining the amount of the at least one 13C labelled metabolization product in the exhalation air over a definite time interval by the means of at least one measuring device with at least one evaluation unit is disclosed. Using this method, it is possible to describe the measured initial increase of the amount of the at least one 13C labelled metabolization product in the exhalation air using a differential equation of first order and to determine a value Amax (DOBmax) and a time constant tau of the increase of the amount of 13C labelled metabolization product from the solution of the differential equation of first order.

Description

technical field [0001] The invention relates to a method for providing raw data for determining the liver performance of an organism. Background technique [0002] The liver is a very important organ for biological, in particular human, functions, since a large number of substrates, eg pharmaceuticals, are decomposed enzymatically in the liver. Here, the decomposition of the substrate is mainly catalyzed by the cytochrome family, in particular in the form of P450 oxygenases. Here, it has long been known that different cytochromes metabolize different substrates. It is also known that the function of the liver can be estimated by measuring the concentration of metabolic substrates. [0003] Therefore, in the literature of Matsumoto et al. (Digestive Diseases Science (digestion and science), 1987, vol. 32, pp. 344–348) described the 13 C Methacetin ( 13 Oral administration of C-Methacetin), wherein 13 C methacetin is released in the liver 13 CO 2 in case of conversion. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61K49/00
CPCA61B5/412A61B5/00A61B5/413A61B5/4244A61K49/0004A61B5/097A61B5/0836A61B5/083A61K49/1815
Inventor 卡斯滕·海涅梅尔廷·施托克曼
Owner HUMEDICS
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