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Determining the liver function by quantitatively measuring the metabolism of substrates

A technology for metabolites and substrates, applied in diagnostic recording/measurement, pharmaceutical formulations, drug delivery, etc., can solve problems such as impossibility, no change, offset determination of individual quantification, etc.

Active Publication Date: 2012-09-12
HUMEDICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] 5.) Metabolic processes do not vary from person to person in their reaction efficiency, as this would negate the quantitative determination of the individual
[0016] The points detailed are not possible to achieve by means of hitherto known methods

Method used

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  • Determining the liver function by quantitatively measuring the metabolism of substrates
  • Determining the liver function by quantitatively measuring the metabolism of substrates
  • Determining the liver function by quantitatively measuring the metabolism of substrates

Examples

Experimental program
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Embodiment Construction

[0070] In the preferred implementation form of the current method, according to figure 2 The diagram shown in makes the determination of human liver performance. In the measurement process, the substrate to be metabolized is passed, especially 13 C Mesaacetin 1 combined with intravenous administration of physiological saline solution 1a to initiate metabolism.

[0071] Intravenous substrate administration ensures rapid substrate submersion and rapid initialization of substrate metabolism required for evaluation. Here, the initiation of the substrate metabolism caused by the enzymatic conversion of the substrate in the liver is faster than the respiratory rhythm.

[0072] in Image 6 Schematic representation of the transport of the ingested substrate to the liver to neutralize the substrate and the conversion or decomposition that occurs there. E.g 13 The substrate taken by C Methacetin (double-hatched circle) is transported to the liver cells with a special transport constant, bu...

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Abstract

The invention provides a method for determining the function of the living beings, particularly the function of a liver. The method comprises the steps of taking a substrate marked with 13C, with the substrate being converted via the liver to release at least one 13c-marked metabolite and utilizing at least one measuring device having at least one evaluation unit to determine the content of at least one 13C marked metabolite in the exhaled air during a certain time interval. With this method, a differential equation of first order can be used to describe the measured initial rise of the content of at least one 13C marked metabolite in the exhaled air. Moreover, the maximum concentration Amax (DOBmax) and the rising time constant tau of the content of the 13C marked metabolite can be determined via the differential equation of first order.

Description

Technical field [0001] The present invention relates to a method for determining the liver performance of an organism according to the preamble of claim 1. Background technique [0002] The liver is a very important organ for biological, especially human functions, because a large amount of substrates such as medicines are decomposed in the liver in an enzymatic manner. Here, the decomposition of the substrate is mainly catalyzed by the cytochrome family, especially in the form of P450 oxygenase. Here, it has long been known that different cytochromes metabolize different substrates. It is also known that the function of the liver can be estimated by measuring the concentration of metabolic substrates. [0003] Therefore, in the literature by Matsumoto et al. (Digestive Diseases Science, 1987, volume 32, pages 344–348), the 13 C Mesathidine ( 13 C-Methacetin) oral administration, of which 13 C Metacetin is being released in the liver 13 CO 2 In the case of conversion. So here, i...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61K49/00
CPCA61B5/00A61B5/083A61B5/0836A61B5/097A61B5/412A61B5/413A61B5/4244A61K49/0004A61K49/1815
Inventor 卡斯滕·海涅梅尔廷·施托克曼
Owner HUMEDICS
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