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A kind of soft capsule containing salvia miltiorrhiza extract and preparation method thereof

A technology of extracts and soft capsules, applied in the field of soft capsules containing Danshen extract and its preparation, to achieve the effect of improving chemical liver damage and reducing alcoholic liver damage

Active Publication Date: 2017-01-18
侯文阁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Different countries have different requirements for the average per capita intake of polyethylene glycol, so the long-term consumption of this compound in large quantities remains to be understood

Method used

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  • A kind of soft capsule containing salvia miltiorrhiza extract and preparation method thereof
  • A kind of soft capsule containing salvia miltiorrhiza extract and preparation method thereof
  • A kind of soft capsule containing salvia miltiorrhiza extract and preparation method thereof

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preparation example Construction

[0026] The method for preparing the above-mentioned soft capsules provided by the present invention comprises mixing the salvia miltiorrhiza extract, medium-chain triglycerides, edible oil and phospholipids to obtain the contents of the soft capsules, and encapsulating the contents in the soft capsule shell.

[0027] Among them, the soft capsule shell can be prepared in a conventional way, for example, gelatin, purified water, glycerin, sorbitol, glycine and titanium dioxide are added with an appropriate amount of pigment (tartrazine or brilliant blue) to obtain gelatinization. Then, conventional scale preparation methods can be used to make pills, shape and dry, wash pills, dry pills, pick pills, make semi-finished products, and pack.

[0028] According to the present invention, the specific mixing method is not particularly limited. For example, the mixing method may be: dissolving the salvia miltiorrhiza extract, edible oil and phospholipids in medium-chain triglycerides at ...

Embodiment 1

[0032] According to 1000 capsules, under the protection of nitrogen, heat 95g of medium-chain triglycerides in a water bath to 55°C, and at this temperature, add 0.5g of Salvia miltiorrhiza extract, stir until dissolved, and then add 95g of poppy seed oil (unsaturated Fatty acid content is 90% by weight), 110g soybean lecithin (batch number: 576500) and 0.06g vitamin E, stirred until dissolved, cooled to 35°C as the content of the soft capsule for use;

[0033] Prepare the soft capsule shell according to the following weight ratio: gelatin: purified water: glycerin: sorbitol: glycine: titanium dioxide=1:1:0.47:0.02:0.08:0.005 to carry out gelatinization, and the conventional manufacturing method is used to make pills, shape and dry, wash pills, dried pills, and picked pills to obtain soft capsule S-1.

Embodiment 2

[0041] According to 1000 grains, under the protection of nitrogen, heat 80g of medium-chain triglycerides in a water bath to 60°C, and at this temperature, add 0.2g of Danshen extract, stir until dissolved, and then add 120g of soybean oil (unsaturated fatty acid 70% by weight), 80g soybean lecithin (batch number 1032675) and 0.06g vitamin E, stirred until dissolved, cooled to 40°C as the content of the soft capsule for use;

[0042] Prepare the soft capsule shell according to the following weight ratio: gelatin: purified water: glycerin: sorbitol: glycine: titanium dioxide=1:1:0.47:0.02:0.08:0.005 to carry out gelatinization, and the conventional manufacturing method is used to make pills, shape and dry, wash pills, dried pills, and picked pills to obtain soft capsule S-2.

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Abstract

The invention discloses a soft capsule containing salvia miltiorrhiza extract and a preparation method thereof. The content of the soft capsule contains salvia miltiorrhiza extract, medium-chain triglyceride, edible oil and phospholipid, wherein, relative to 1 weight part of salvia miltiorrhiza extract, the content of medium-chain triglycerides is 40-600 parts by weight, the content of edible oil is 50-650 parts by weight, the content of phospholipids is 40-600 parts by weight, and the content of unsaturated fatty acids in the edible oil is not Below 70% by weight, the content of phosphatidylcholine in the phospholipid is 20-80% by weight and the content of dilinoleoylphosphatidylcholine is 20-80% by weight. The preparation method of the soft capsule comprises mixing the above-mentioned ingredients to obtain the content of the soft capsule, and encapsulating the content in a soft capsule shell. The soft capsule of the invention can effectively improve chemical liver damage, alcoholic liver damage and lower blood lipids, and active ingredients such as salvia miltiorrhiza extract and phospholipid can exist stably for a long time.

Description

technical field [0001] The invention relates to a soft capsule containing salvia miltiorrhiza extract and a preparation method thereof. Background technique [0002] Salvia miltiorrhiza is a perennial herb of Lamiaceae, which is often used clinically for promoting blood circulation and removing blood stasis of cardiovascular and cerebrovascular diseases. Modern studies have shown that Danshen can promote the differentiation and proliferation of liver cells, improve the regenerative capacity of the liver, and can partially reverse the inhibitory effect of alcohol on liver regeneration. Tanshinone IIA is one of the main active ingredients of Danshen and a natural antioxidant. Tanshinone IIA protects the liver by scavenging oxygen free radicals, exerting anti-oxidation and alleviating lipid peroxidation. (Jiang Huidi, Huang Xiaqin and Yang Yi, Research on the anti-lipid peroxidation effect of nine liver-protecting traditional Chinese medicines [J], Chinese Materia Medica, 199...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/48A61P1/16A61P3/06A61K47/14A61K47/24
Inventor 陈曦侯琬实侯文阁
Owner 侯文阁
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