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Soft capsule containing salvia miltiorrhiza extract and preparation method thereof

A soft capsule and extract technology are applied in the field of soft capsules containing salvia miltiorrhiza extract and preparation thereof, and achieve the effect of improving chemical liver injury and reducing alcoholic liver injury

Active Publication Date: 2014-06-04
侯文阁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different countries have different requirements for the average per capita intake of polyethylene glycol, so the long-term consumption of this compound in large quantities remains to be understood

Method used

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  • Soft capsule containing salvia miltiorrhiza extract and preparation method thereof
  • Soft capsule containing salvia miltiorrhiza extract and preparation method thereof
  • Soft capsule containing salvia miltiorrhiza extract and preparation method thereof

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preparation example Construction

[0026] The method for preparing the above-mentioned soft capsules provided by the present invention comprises mixing the salvia miltiorrhiza extract, medium-chain triglycerides, edible oil and phospholipids to obtain the contents of the soft capsules, and encapsulating the contents in the soft capsule shell.

[0027] Among them, the soft capsule shell can be prepared in a conventional way, for example, gelatin, purified water, glycerin, sorbitol, glycine and titanium dioxide are added with an appropriate amount of pigment (tartrazine or brilliant blue) to obtain gelatinization. Then, conventional scale preparation methods can be used to make pills, shape and dry, wash pills, dry pills, pick pills, make semi-finished products, and pack.

[0028] According to the present invention, the specific mixing method is not particularly limited. For example, the mixing method may be: dissolving the salvia miltiorrhiza extract, edible oil and phospholipids in medium-chain triglycerides at ...

Embodiment 1

[0032] According to 1000 capsules, under the protection of nitrogen, heat 95g of medium-chain triglycerides in a water bath to 55°C, and at this temperature, add 0.5g of Salvia miltiorrhiza extract, stir until dissolved, and then add 95g of poppy seed oil (unsaturated Fatty acid content is 90% by weight), 110g soybean lecithin (batch number: 576500) and 0.06g vitamin E, stirred until dissolved, cooled to 35°C as the content of the soft capsule for use;

[0033] Prepare the soft capsule shell according to the following weight ratio: gelatin: purified water: glycerin: sorbitol: glycine: titanium dioxide=1:1:0.47:0.02:0.08:0.005 to carry out gelatinization, and the conventional manufacturing method is used to make pills, shape and dry, wash pills, dried pills, and picked pills to obtain soft capsule S-1.

Embodiment 2

[0041] According to 1000 grains, under the protection of nitrogen, heat 80g of medium-chain triglycerides in a water bath to 60°C, and at this temperature, add 0.2g of Danshen extract, stir until dissolved, and then add 120g of soybean oil (unsaturated fatty acid 70% by weight), 80g soybean lecithin (batch number 1032675) and 0.06g vitamin E, stirred until dissolved, cooled to 40°C as the content of the soft capsule for use;

[0042] Prepare the soft capsule shell according to the following weight ratio: gelatin: purified water: glycerin: sorbitol: glycine: titanium dioxide=1:1:0.47:0.02:0.08:0.005 to carry out gelatinization, and the conventional manufacturing method is used to make pills, shape and dry, wash pills, dried pills, and picked pills to obtain soft capsule S-2.

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Abstract

The invention discloses a soft capsule containing a salvia miltiorrhiza extract and a preparation method thereof. The content of the soft capsule disclosed by the invention contains the salvia miltiorrhiza extract, medium-chain triglyceride, edible oil and phospholipid, wherein corresponding to 1 part by weight of the salvia miltiorrhiza extract, the content of medium-chain triglyceride is 40-600 parts by weight; the content of edible oil is 50-650 parts by weight; the content of phospholipid is 40-600 parts by weight; the content of unsaturated fatty acid in edible oil is not less than 70% by weight; the content of phosphatidylcholine in phospholipid is 20-80% by weight, and the content of dilinolein diplmitoyl phosphtidyl choline is 20-80% by weight. The preparation method of the soft capsule disclosed by the invention comprises the following steps of: mixing various components to obtain the content of the soft capsule; packaging the content in the shell of soft capsule. The soft capsule disclosed by the invention is capable of effectively improving chemical liver injury and alcoholic liver injury and reducing blood fat; furthermore, the active components, such as the salvia miltiorrhiza extract, phospholipid and the like, can exist stably for a long time.

Description

technical field [0001] The invention relates to a soft capsule containing salvia miltiorrhiza extract and a preparation method thereof. Background technique [0002] Salvia miltiorrhiza is a perennial herb of Lamiaceae, which is often used clinically for promoting blood circulation and removing blood stasis of cardiovascular and cerebrovascular diseases. Modern studies have shown that Danshen can promote the differentiation and proliferation of liver cells, improve the regenerative capacity of the liver, and can partially reverse the inhibitory effect of alcohol on liver regeneration. Tanshinone IIA is one of the main active ingredients of Danshen and a natural antioxidant. Tanshinone IIA protects the liver by scavenging oxygen free radicals, exerting anti-oxidation and alleviating lipid peroxidation. (Jiang Huidi, Huang Xiaqin and Yang Yi, Research on the anti-lipid peroxidation effect of nine liver-protecting traditional Chinese medicines [J], Chinese Materia Medica, 199...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/48A61P1/16A61P3/06A61K47/14A61K47/24
Inventor 陈曦侯琬实侯文阁
Owner 侯文阁
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