A real-time multimodal photoacoustic human eye imaging system and its imaging method

Abstract

The invention discloses a real-time multi-mode photoacoustic human eye imaging system and an imaging method thereof. The imaging system comprises a laser device, a front optical path, a reflecting mirror, a focusing lens, a light-transmitting acoustic reflection device, a scanning mirror, a water trough, an ultrasonic probe, an ultrasonic transmitter-receiver set, an amplifier and a computer. A light-transmitting acoustic reflection film and the scanning mirror are placed in the water trough. The imaging system has a photoacoustic imaging mode and an ultrasonic imaging mode. Mechanical scanning is replaced through the scanning mirror, imaging time is greatly shortened, and pain of a patient is relieved. Meanwhile, due to the optical and ultrasonic confocal design, an existing pure optical focusing imaging mode or an existing pure ultrasonic focusing imaging mode is changed, sensitivity is improved on the basis that the optical resolution is achieved, and full-eye imaging from the front of the eye to the bottom of the eye can be carried out. Due to dual-wavelength use, the limitation that imaging is only carried out on the eye vascular structure at present is broken through, functional imaging of the degree of blood oxygen saturation can be carried out, and early detection of a part of eye diseases is facilitated.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a functional high-resolution real-time multi-mode photoacoustic human eye imaging system and an imaging method thereof. Background technique [0002] The current methods of eye disease examination mainly include ophthalmoscopy, ocular ultrasound imaging, optical coherence tomography and so on. Ophthalmoscopy is the simplest means of eye disease examination and is easy to operate, but it cannot give three-dimensional structure and function information; ocular ultrasound imaging can not only distinguish the various layers of eye tissue structurally, but also display blood flow information through Doppler. It can be used for the examination of various structural and functional lesions, but the contrast and sensitivity are not high, and the subjective factors of the diagnostician are large; optical coherence tomography (OCT) is a new technology for high-resolution cross-sectiona...

AI Technical Summary

Problems solved by technology

The photoacoustic eye imaging system designed by Silverman and Adam respectively realizes the whole-eye ultrasound and photoacoustic dual-modal imaging, but the resolution of these two systems is low due to the focusing based on acoustics.

Generally speaking, the existing photoacoustic eye imaging equipment in the world does not combine high-resolution functional photoacoustic microscopic imaging with the most commonly used ultrasonic structural imaging in ophthalmic examinations to achieve complete vision from the front to the back of the eye. High-resolution functional whole-eye multimodal photoacoustic imaging

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