Diffuse axonal injury experimental setup

Abstract

The invention discloses a diffuse axonal injury experimental device. The diffuse axonal injury experimental device comprises a trunk plate which is used for fixing a trunk and a head plate which is used for fixing a head; the trunk plate and the head plate are provided with binding belts which are used for binding up experimental animals; the trunk plate and the head plate are connected through a fixed shaft; the trunk plate and the head plate are driven by a motor A and a motor B to rotate towards the fixed shaft. During an experiment, the animal trunk and the animal head which are arranged on the trunk plate and the head plate respectively are bound up by the binding belts, the motor B is individually driven to enable the animal head to rotate to generate angular acceleration to enable the animal head to generate diffuse axonal injury, and then analysis and simulation of a mechanism of the head diffuse axonal injury can be performed; the motor can be individually driven to enable the animal trunk to rotate to enable an animal neck to generate relative angular acceleration; meanwhile, the motor A and the motor B are driven to enable the animal trunk and the animal head to rotate relatively and then analysis of a mechanism of brain diffuse axonal injury due to the fact that the head and the trunk are injured in different degrees can be performed.

Description

technical field [0001] The invention relates to the field of medical diagnosis research, in particular to an experimental device for diffuse axonal injury. Background technique [0002] Diffuse axonal injury: (diffuse axonalinjury, DAI): refers to a primary brain parenchymal injury that occurs after trauma to the head, and is mainly diffusely distributed in the white matter of the brain, with axonal damage as the main change. Its characteristics are: 1) extensive white matter degeneration, small focal hemorrhage; 2) axonal retraction balls, microglial clusters appear; 3) often combined with other craniocerebral injuries, high mortality. With the improvement of pathological diagnosis technology, the establishment of various animal models and the improvement of high-resolution and high-definition imaging technology have provided powerful help for the diagnosis and treatment of this disease. At present, the understanding of the pathogenesis of DAI is basically consistent, that...

AI Technical Summary

Problems solved by technology

But so far, the research on the diagnosis of this disease is still preliminary, there is no unified diagnostic standard, and the relationship with other types of brain injury is not clear, which hinders the understanding of the nature of the disease and makes it difficult to achieve breakthroughs in treatment measures

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