A compound drug combination for treating dyslipidemia and atherosclerosis
A drug and composition technology, applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., can solve problems that have not been used to improve dyslipidemia
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Embodiment 1
[0026] Therapeutic effect of drugs on hyperlipidemia model in mice induced by high-fat diet
[0027] Compare the therapeutic effect of SAR combined with pCPA, CDP, BSA, and each alone on the hyperlipidemia model of rats fed with high-fat diet, so as to verify the synergistic effect of combined administration of SAR, pCPA, CDP, and BSA on the treatment of dyslipidemia effect.
[0028] 2.1 Experimental method
[0029] (1) Animal handling
[0030] 180 male ICR mice were randomly divided into 18 groups (10 in each group): control group, dyslipidemia model group, dyslipidemia model SAR treatment group, dyslipidemia model SAR+pCPA compound treatment group (SAR: pCPA was formulated according to different weights). 4 kinds of compound prescriptions compared with each other), dyslipidemia model pCPA treatment group, dyslipidemia model SAR+CDP compound treatment group (SAR:CDP is 4 kinds of compound according to different weight ratios), dyslipidemia model CDP treatment group, dyslipi...
Embodiment 2
[0074] Therapeutic effect of drugs on DEX-induced dyslipidemia rat model
[0075] Compare the therapeutic effects of SAR combined with pCPA, CDP, BSA, and each alone on the DEX-induced dyslipidemia model in rats (simulating the situation of long-term mental stress or chronic stress in humans), so as to re-verify the relationship between SAR and pCPA, CDP , The synergistic effect of BSA combined administration on the treatment of dyslipidemia.
[0076] 3.1 Experimental method
[0077] (1) Animal handling
[0078] 144 male SD rats were randomly divided into 18 groups (8 rats in each group): control group, model group, model SAR treatment group, model SAR+pCPA compound treatment group (SAR: 4 kinds of compounds of pCPA in different weight ratios) , model pCPA treatment group, model SAR+CDP compound treatment group (SAR: CDP in different weight ratios of 4 kinds of compounds), model CDP treatment group, model SAR+BSA compound treatment group (SAR: BSA in different weight ratios ...
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