System for full-automated and online detection of perfluoro and polyfluoro compounds in serum

A fully automatic technology of polyfluorinated compounds, applied in the field of serum detection, can solve the problems of time-consuming and labor-consuming, and achieve the effect of solving time-consuming and labor-consuming, avoiding experimental errors, and good reproducibility

Inactive Publication Date: 2016-04-20
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

[0004] The purpose of the present invention is to provide a fully automatic online detection system for perfluorinated and polyfluorinated compounds in serum. This system does not need to go through complicated manual pretreatment process, and solves the problem of time-consuming and labor-consuming

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  • System for full-automated and online detection of perfluoro and polyfluoro compounds in serum
  • System for full-automated and online detection of perfluoro and polyfluoro compounds in serum
  • System for full-automated and online detection of perfluoro and polyfluoro compounds in serum

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Embodiment Construction

[0014] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0015] Embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings, as figure 1 Shown is a schematic structural diagram of a system for fully automatic on-line detection of perfluorinated and polyfluorinated compounds in serum provided by an embodiment of the present invention. instrument, of which:

[0016] The double-ternary liquid chromatograph specifically includes: a left pump, ...

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Abstract

The invention discloses a system for full-automated and online detection of perfluoro and polyfluoro compounds in serum. The system comprises a purification column, an analyzing column, a dual ternary liquid phase chromatograph, and a triple quadrupole detector, wherein an automatic sampler of the dual ternary liquid phase chromatograph is used for directly absorbing serum samples to be loaded forwards towards the purification column, and the analyzing column is flushed; after the serum samples are loaded, the purification column is back flushed for eluting target compounds, and the samples are fed into the analyzing column; after the serum sample are eluted, the line connection returns to the initial stage, and a left pump is used for regenerating the purification column; a right pump is used for introducing the samples into the triple quadrupole detector, so that detection of perfluoro compounds in the serum is realized. The system does not need a complex artificial preprocessing process, and the problems that the analyzing method of a conventional instrument is time-consuming and labor-consuming in the preprocessing course and the samples run off seriously are solved.

Description

technical field [0001] The invention relates to the technical field of serum detection, in particular to a fully automatic on-line detection system for perfluorinated and polyfluorinated compounds in serum. Background technique [0002] The online solid-phase extraction liquid chromatography technology developed in recent years can realize the online enrichment of samples, minimize manual operations and human errors, and is gradually being applied to the detection of trace target substances in environmental and biological samples due to its automatic and efficient features. analyze. The packing feature of the online vortex solid phase extraction column (TurboFlow-SPE) combines the retention characteristics of size exclusion and reversed-phase chromatography. Due to the large particle size of the packing (60 μm), the sample is in a turbulent state at a high flow rate and can be removed. Large molecules, retain small molecules; TurboFlow-SPE technology has been used to detect...

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 傅建捷高珂张爱茜
Owner RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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