Device for manufacturing artificial blood vessel through combination of bio-printing and electro-spinning technologies

Abstract

The invention discloses a device for manufacturing an artificial blood vessel through combination of bio-printing and electro-spinning technologies. The device comprises a material release unit, a rotary receiving unit, a horizontal moving platform, a vertical moving platform, a high-voltage power supply and a control unit, wherein the rotary receiving unit is located below the material release unit and comprises a rotary motor and a receiving rod; the rotary motor can drive the receiving rod to conduct rotary operation. The device has the following benefits: during operation, when the material release unit uses a bio-printing nozzle, a first stepping motor controls an extrusion pump to extrude out a cell-containing hydrogel material in a storage tank, and the extrusion pump can realize setting and controlling of the material release speed and quantity by the control unit; the vertical moving platform controls relative displacement of the whole material release unit to the rotary receiving unit, and can conduct vertical up-and-down displacement (such as 0.1 mm, 0.5 mm, 5 mm and continuous displacement), the displacement can be adjusted according to the extrusion requirement, and the distance between the bio-printing nozzle and the rotary receiving unit is adjusted through the displacement; the bio-printing nozzle and electro-spinning nozzles can work simultaneously or alternately, which is adjusted by the control unit according to actual demands.

Description

technical field [0001] The invention belongs to the field of medical experiments, in particular to a device for manufacturing artificial blood vessels by combining bioprinting and electrospinning technologies. Background technique [0002] The invention of artificial blood vessels has brought good news to clinical patients. There are various techniques and methods for making artificial blood vessels, and the materials are also rich and varied. However, these are some degradable or non-degradable scaffold structures or lumen structures to replace blood vessels, some of which are not conducive to cell colonization, growth, and differentiation, and some are non-human inherent polymers, and cytotoxicity and metabolic toxicity are inevitable. , and some are not strong enough. Moreover, these are inactive blood vessels mainly made of materials, and biomanufacturing of high-strength blood vessels with bioactivity will provide more favorable conditions for the development of clini...

AI Technical Summary

Problems solved by technology

However, these are the use of some degradable or non-degradable scaffold structures or lumen structures to replace blood vessels, some of which are not conducive to cell colonization, growth, and differentiation, and some are non-human-inherent polymers, and cytotoxicity and metabolic toxicity are inevitable. , and some are not strong enough

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