Device for manufacturing artificial blood vessel through combination of bio-printing and electro-spinning technologies

An electrospinning technology and bioprinting technology, applied in the field of medical experiments, can solve the problems of insufficient strength, unfavorable cell colonization, growth and differentiation, inevitable cytotoxicity and metabolic toxicity, etc.

Inactive Publication Date: 2016-10-12
THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these are the use of some degradable or non-degradable scaffold structures or lumen structures to replace blood vessels, some of which are not conducive to cell co

Method used

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  • Device for manufacturing artificial blood vessel through combination of bio-printing and electro-spinning technologies

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Embodiment Construction

[0015] Attached below figure 1 The present invention is described in further detail.

[0016] Such as figure 1 As shown, the device for manufacturing artificial blood vessels combined with bioprinting and electrospinning technology according to the embodiment of the present invention includes a material releasing unit 1, a rotating receiving unit 2, a horizontal moving platform 3, a vertical moving platform 4, a high voltage power supply 5 and a control Unit 6.

[0017] The material release unit 1 includes a first motor 7, an extrusion pump 8, a storage tank 9, a heating and heat preservation device 10, a bioprinting nozzle 11, and two electrospinning nozzles 12. The hydrogel containing cells is stored in the storage tank 9. glue material, the first motor 7 is connected with the extrusion pump 8, the first motor 7 drives the extrusion pump 8 to move, the heating and heat preservation device 10 is arranged on the outside of the storage tank 9, and the bioprinting nozzle 11 co...

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Abstract

The invention discloses a device for manufacturing an artificial blood vessel through combination of bio-printing and electro-spinning technologies. The device comprises a material release unit, a rotary receiving unit, a horizontal moving platform, a vertical moving platform, a high-voltage power supply and a control unit, wherein the rotary receiving unit is located below the material release unit and comprises a rotary motor and a receiving rod; the rotary motor can drive the receiving rod to conduct rotary operation. The device has the following benefits: during operation, when the material release unit uses a bio-printing nozzle, a first stepping motor controls an extrusion pump to extrude out a cell-containing hydrogel material in a storage tank, and the extrusion pump can realize setting and controlling of the material release speed and quantity by the control unit; the vertical moving platform controls relative displacement of the whole material release unit to the rotary receiving unit, and can conduct vertical up-and-down displacement (such as 0.1 mm, 0.5 mm, 5 mm and continuous displacement), the displacement can be adjusted according to the extrusion requirement, and the distance between the bio-printing nozzle and the rotary receiving unit is adjusted through the displacement; the bio-printing nozzle and electro-spinning nozzles can work simultaneously or alternately, which is adjusted by the control unit according to actual demands.

Description

technical field [0001] The invention belongs to the field of medical experiments, in particular to a device for manufacturing artificial blood vessels by combining bioprinting and electrospinning technologies. Background technique [0002] The invention of artificial blood vessels has brought good news to clinical patients. There are various techniques and methods for making artificial blood vessels, and the materials are also rich and varied. However, these are some degradable or non-degradable scaffold structures or lumen structures to replace blood vessels, some of which are not conducive to cell colonization, growth, and differentiation, and some are non-human inherent polymers, and cytotoxicity and metabolic toxicity are inevitable. , and some are not strong enough. Moreover, these are inactive blood vessels mainly made of materials, and biomanufacturing of high-strength blood vessels with bioactivity will provide more favorable conditions for the development of clini...

Claims

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Application Information

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IPC IPC(8): D01D5/00B29C67/00B33Y10/00B33Y30/00B33Y50/02
CPCD01D5/0061B33Y10/00B33Y30/00B33Y50/02D10B2509/06
Inventor 兰青代兴亮
Owner THE SECOND HOSPITAL AFFILIATED TO SUZHOU UNIV
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