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A compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer, its preparation method and application

A technology of compound Chinese medicine and colorectal cancer, which is applied in the field of inhibiting liver metastasis of colorectal cancer and the preparation of compound Chinese medicine composition, can solve the problems of radiotherapy efficiency to be improved and the opportunity of surgery lost, and achieve low production cost and reduce liver cancer. Effect of transferring, easy to promote the application

Active Publication Date: 2019-07-02
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some patients have already metastasized when the tumor is found, and they lose the chance of surgery
The side effects of chemotherapy often prevent patients from adhering to the final course of treatment, and even after a complete course of chemotherapy, there is only close follow-up and no targeted further treatment; at the same time, due to the dual limitations of equipment and tumor types, the effectiveness of radiotherapy needs improvement

Method used

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  • A compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer, its preparation method and application
  • A compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer, its preparation method and application
  • A compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer, its preparation method and application

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Effect test

Embodiment 1

[0033] A compound combination medicine for reducing liver metastasis of colorectal cancer, consisting of the following components by weight:

[0034] 15 parts of Roasted Astragalus, 15 parts of Fried Codonopsis, 10 parts of Fried Atractylodes, 15 parts of Poria, 15 parts of Chinese Yam, 5 parts of Roasted Licorice, 10 parts of Roasted Ume, 10 parts of Triangle, 10 parts of Curcuma, 30 parts of Agrimony, 30 parts of Pain 30 servings, 11 medicines in total.

[0035] According to the prescription ratio, weigh the above 11 pieces of traditional Chinese medicine, add 10 times the total weight of the crude drug in water, decoct and extract 3 times, each for 1 hour. Combine the decoction to form a decoction.

[0036] The obtained decoction is concentrated to a relative density of 1.10 (measured at 60°C), ethanol is added to the alcohol content to reach 60%, and it is allowed to stand for more than 12 hours. The supernatant was filtered, ethanol was recovered to the end, and concentrated t...

Embodiment 2

[0038] A compound combination medicine for reducing liver metastasis of colorectal cancer, consisting of the following components by weight:

[0039] 15 parts of Roasted Astragalus, 30 parts of Fried Codonopsis, 10 parts of Fried Atractylodes, 20 parts of Poria, 15 parts of Chinese Yam, 5 parts of Roasted Licorice, 10 parts of Roasted Ume, 15 parts of Triangle, 15 parts of Curcuma, 30 parts of Agrimony, 30 parts of Paijiangcao 30 servings, 11 medicines in total.

[0040] According to the prescription ratio, weigh the above 11 pieces of traditional Chinese medicine, add 20 times the total weight of the raw material medicine in water, decoct and extract 3 times, each time for 1 hour. Combine the decoction and concentrate to a relative density of 1.08 (measured at 60°C), add ethanol to an alcohol content of 60%, stand for more than 24 hours, filter the supernatant, recover the ethanol to the end, and concentrate to a relative density of about 1.08 ( 60 ℃ test). Add distilled water t...

Embodiment 3

[0042] A compound combination medicine for reducing liver metastasis of colorectal cancer, consisting of the following components by weight:

[0043] 20 parts of Roasted Astragalus, 20 parts of Fried Codonopsis, 15 parts of Fried Atractylodes, 15 parts of Poria, 15 parts of Chinese Yam, 10 parts of Roasted Licorice, 15 Parts of Roasted Ume, 10 Parts of Triangle, 10 Parts of Turmeric, 15 Parts of Agrimony, 15 Parts of Pain 15 servings, 11 medicines in total.

[0044] According to the prescription ratio, weigh the above 11 pieces of traditional Chinese medicine, add 5 times the total weight of the raw material medicine in water, decoct and extract 3 times, 1 hour each time. Combine the decoction, concentrate to a relative density of 1.10 (measured at 60°C), add ethanol to an alcohol content of 60%, stand for more than 24 hours, filter the supernatant, recover the ethanol to the end, and concentrate to a relative density of about 1.33 ( 60 ℃ test). Add appropriate amount of dextrin ...

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Abstract

A compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer, comprising the following components in parts by weight: 15-30 parts of Radix Astragalus Radix, 15-30 parts of Fried Codonopsis Codonopsis, 10-20 parts of Fried Atractylodes Rhizoma Atractylodes Rhizome, 15-30 parts of Poria cocos, 15-30 parts of yam, 5-10 parts of roasted licorice, 10-20 parts of sun-burned black plum, 10-20 parts of trigonum, 10-20 parts of curcuma, 15-30 parts of Agrimony, and 15-30 parts of Patrinia. The invention also discloses a preparation method of the compound traditional Chinese medicine composition and its application in the preparation of medicines for treating colorectal cancer liver metastasis.

Description

Technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to a preparation method and application of a compound traditional Chinese medicine composition for inhibiting liver metastasis of colorectal cancer. Background technique [0002] Malignant tumors are one of the common chronic non-communicable diseases worldwide. Surgery, chemotherapy, radiotherapy and biological therapy are the conventional medical treatments for tumor patients. However, some patients have metastasized when the tumor is found, and have lost the opportunity for surgery. The side effects of chemotherapy often make patients unable to adhere to the final course of treatment. Moreover, even after a complete course of chemotherapy, there is only close follow-up and no targeted further treatment; at the same time, due to the dual limitations of equipment and tumor types, the effective rate of radiotherapy Room for improvement. Biological therapy is an emerging treatm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P35/04A61K31/513
CPCA61K31/513A61K36/076A61K36/284A61K36/344A61K36/481A61K36/484A61K36/73A61K36/736A61K36/84A61K36/8945A61K36/902A61K36/9066A61K2236/331A61K2236/333A61K2236/51A61K2300/00
Inventor 周锦勇刘沈林陈玉根朱学军
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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