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Hydroxyapatite micro-sphere and method for preparing same

A technology of hydroxyapatite and microspheres, applied in chemical instruments and methods, pharmaceutical formulations, phosphorus compounds, etc. Loose structure and other problems, to achieve a good support effect, not easy to reunite, easy to inject the effect

Inactive Publication Date: 2017-07-21
SHANGHAI REBONE BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects of loose structure of hydroxyapatite microspheres in the prior art, poor shape maintenance

Method used

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  • Hydroxyapatite micro-sphere and method for preparing same
  • Hydroxyapatite micro-sphere and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) adjust the pH value of the diammonium hydrogen phosphate aqueous solution to 10 to obtain a mixed solution 1;

[0036] (2) After calcium nitrate aqueous solution is mixed with gained mixed solution 1, get mixed solution 2, adjust the pH value of gained mixed solution 2 to 12, react under stirring, stirring speed is 500r / min, and reaction temperature is 70 ℃, The reaction time was 24 hours, and mixed solution 3 was obtained;

[0037] (3) Filter the obtained mixed solution 3 with a microporous membrane, the aperture of which is 0.22 μm, to obtain a filter cake;

[0038] (4) washing the obtained filter cake with deionized water for 3 times, washing with absolute ethanol for 3 times, drying at 100° C. for 15 hours, and grinding for 2 hours to obtain a powder;

[0039] (5) The obtained powder is made into an aqueous solution with a mass fraction of 50% for spraying;

[0040] Wherein, the concentration of the diammonium hydrogen phosphate aqueous solution is 0.5mol / L; t...

Embodiment 2

[0043] (1) adjust the pH value of the disodium hydrogen phosphate aqueous solution to 11 to obtain the mixed solution 1;

[0044] (2) After calcium nitrate aqueous solution is mixed with gained mixed solution 1, get mixed solution 2, adjust the pH value of gained mixed solution 2 to 12, react under stirring, stirring speed is 300r / min, and reaction temperature is 50 ℃, The reaction time was 24 hours, and mixed solution 3 was obtained;

[0045] (3) Filter the obtained mixed solution 3 with a microporous membrane, the aperture of which is 0.22 μm, to obtain a filter cake;

[0046](4) The obtained filter cake was washed 3 times with deionized water and 3 times with absolute ethanol, dried at 100° C. for 10 hours, and pulverized for 4 hours to obtain a powder;

[0047] (5) The obtained powder is made into an aqueous solution with a mass fraction of 50% for spraying;

[0048] Wherein, the concentration of the disodium hydrogen phosphate aqueous solution is 0.5mol / L; the concentra...

Embodiment 3

[0051] (1) adjust the pH value of the potassium dihydrogen phosphate aqueous solution to 10 to obtain a mixed solution 1;

[0052] (2) After calcium nitrate aqueous solution is mixed with gained mixed solution 1, get mixed solution 2, adjust the pH value of gained mixed solution 2 to 11, react under stirring, stirring speed is 700r / min, and reaction temperature is 30 ℃, The reaction time was 36 hours, and mixed solution 3 was obtained;

[0053] (3) Filter the obtained mixed solution 3 with a microporous membrane, the aperture of which is 0.22 μm, to obtain a filter cake;

[0054] (4) washing the obtained filter cake with deionized water for 3 times, washing with absolute ethanol for 3 times, drying at 100° C. for 15 hours, and grinding for 2 hours to obtain a powder;

[0055] (5) The obtained powder is made into an aqueous solution with a mass fraction of 50% for spraying;

[0056] Wherein, the concentration of the potassium dihydrogen phosphate aqueous solution is 0.5mol / L;...

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Abstract

The invention provides a hydroxyapatite micro-sphere and a method for preparing the same. The method includes regulating a pH (potential of hydrogen) value of phosphate aqueous solution until the phosphate aqueous solution is alkaline, mixing the phosphate aqueous solution and calcium nitrate aqueous solution with each other to obtain mixed solution, regulating a pH value of the obtained mixed solution until the mixed solution is alkaline, carrying out reaction on the mixed solution, filtering, washing and drying reaction products and then grinding the reaction products for 2-6 hours to obtain powder; preparing aqueous solution with the mass fraction of 10%-50% from the powder and carrying out mist spray. A ratio of the molar weight of phosphate in the phosphate aqueous solution to the molar weight of calcium nitrate in the calcium nitrate aqueous solution is 3:5; mist spray process parameters include that the flow of the aqueous solution is 7.5-30 mL/min, the mist spray pressures are 0.01-0.3 MPa, the inlet air rate is 1.3-3 m<3>/min, and the inlet air temperatures are 150-400 DEG C. The hydroxyapatite micro-sphere and the method have the advantages that the hydroxyapatite micro-sphere prepared by the aid of the method is stable in structure, is a spherical large particle and is easy to inject, agglomeration can be prevented, and good support effects can be realized if the hydroxyapatite micro-sphere is injected into a human body.

Description

technical field [0001] The invention relates to a hydroxyapatite microsphere and a preparation method thereof. Background technique [0002] Calcium phosphate is an important class of biominerals, which commonly exists in the inorganic hard tissues of living organisms, and has various phases and crystal forms. Among them, hydroxyapatite (referred to as HA) is the most thermodynamically stable phase among various calcium phosphates, and its molecular formula is Ca 10 (PO 4 ) 6 (OH) 2 , the Ca / P ratio is 1.67, and the crystal is hexagonal. It is the main inorganic mineral component of human and animal bones. HA has become an important research object in the fields of biology, medicine and materials because of its special surface properties, good biocompatibility, bioactivity and osteoconduction. Microsphere materials have good properties that other irregular-shaped materials do not have, such as good fluidity, high bulk density, light weight, high strength, not easy to ag...

Claims

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Application Information

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IPC IPC(8): C01B25/32A61L31/02A61L31/14
CPCA61L31/028A61L31/14C01B25/325C01P2004/32C01P2004/03C01P2004/61A61L2400/06
Inventor 陈菲
Owner SHANGHAI REBONE BIOMATERIALS