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Application of a long non-coding RNA and its composition in the diagnosis/treatment of gastric cancer

A non-coding, RNA--NFIA-AS1 technology, applied in the field of genetic engineering, can solve problems such as poor prognosis

Inactive Publication Date: 2021-08-13
NANJING PUKOU CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The rapid progression and metastasis of the disease lead to poor prognosis

Method used

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  • Application of a long non-coding RNA and its composition in the diagnosis/treatment of gastric cancer
  • Application of a long non-coding RNA and its composition in the diagnosis/treatment of gastric cancer
  • Application of a long non-coding RNA and its composition in the diagnosis/treatment of gastric cancer

Examples

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Embodiment Construction

[0033] The following examples are used to further illustrate the present invention, but the present invention is not limited thereto. In the following examples, the experimental methods without specific conditions are usually in accordance with conventional conditions, or in accordance with the conditions suggested by the manufacturer.

[0034] The collection of organizations

[0035] Based on histopathological analysis (according to the Seventh Edition of AJCC Cancer Staging Manual), we collected 42 patients with gastric cancer who were diagnosed and surgically treated in Jiangsu Provincial People's Hospital from 2006 to 2008. Tissue samples were collected in liquid nitrogen for the first time or stored at -80°C until RNA extraction. The study was approved by the Ethics Committee of Nanjing Medical University. Written informed consent was obtained from all patients.

[0036] 2. Experimental equipment and reagents

[0037] Experimental methods and research techniques used ...

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PUM

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Abstract

The invention belongs to the field of genetic engineering, and particularly relates to a long-chain non-coding RNA, NFIA‑AS1 and its composition, and its application in the preparation, diagnosis and target drug treatment of gastric cancer. Simultaneously, the present invention also relates to the application of the primers in the preparation of reagents for diagnosing gastric cancer. By studying the expression of the long-chain non-coding RNA at the cellular level, the relationship between it and the pathogenesis of gastric cancer was revealed.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and particularly relates to a long-chain non-coding RNA, NFIA-AS1 and a composition thereof, which are used in the preparation of diagnosing gastric cancer and target drug therapy. At the same time, the present invention also relates to the application of the primers in the preparation of reagents for diagnosing gastric cancer. Background technique [0002] Gastric cancer (GC) is the second leading cause of death from cancer worldwide. The rapid development and metastasis of the disease lead to its poor prognosis. In order to improve the early diagnosis and targeted therapy of GC, there is an urgent need to understand its underlying molecular mechanisms and to identify novel and effective novel biomarkers and therapeutic targets. [0003] Long non-coding RNAs (lncRNAs) are a class of RNA molecules with a transcript length of more than 200 nt. Different from other small non-coding RNAs, they c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886A61K45/00A61P35/00C12N15/11
CPCA61K45/00C12Q1/6886C12Q2600/158C12Q2600/178
Inventor 陆志斌
Owner NANJING PUKOU CENT HOSPITAL
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