Application of gweicurculactone in aspect of treating gynecological tumor

A technology of gynecological tumors and curcuma, which is applied in the field of medicine and can solve problems such as death and evolution

Inactive Publication Date: 2019-03-19
淮安培元基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although complete remission can be achieved after initial surgery and chemotherapy, most patients with advanced disease will still relapse within 2 to 3 years, and eventually become resistant to chemotherapy and die

Method used

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  • Application of gweicurculactone in aspect of treating gynecological tumor
  • Application of gweicurculactone in aspect of treating gynecological tumor

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Embodiment Construction

[0015] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0016] 1. Experimental materials

[0017] The structural formula of the test compound is as figure 1 As shown, including trumpetene, trumpet alcohol, cinnamonolide, isoartemisinic acid, 7-armentene-6-one and 4-arrene, the standard products are purchased or self-made, and the purity is ≥98%.

[0018] Human ovarian cancer SKOV3 cells and human cervical cancer Hela cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0019] DMEM / F12 medium, high-glucose DMEM medium, and fetal bovine serum were purchased from GIBCO.

[0020] Tetramethylazolazolium blue (MTT) and DMSO were purchased from SIGMA.

[0021] Double antibody solution and trypsin were purchased from Hyclone Company, USA.

[0022] 2. Experimental method

[0023] 1. Cell culture

[002...

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Abstract

The invention discloses application of gweicurculactone in the aspect of treating gynecological tumor. The application finds gweicurculactone, isorupestonic acid, 7-aromadendrene-6-ketone and 4-aromadendrene have excellent proliferation inhibiting effect on human ovarian cancer SKOV3 cell and human cervical cancer Hela cell; although camelliene is a dehydration product of ledol in chemical structure which is similar, camelliene is different from ledol in activity of inhibiting proliferation of the human ovarian cancer SKOV3 cell and the human cervical cancer Hela cell, wherein camelliene has obvious inhibiting effect on human cervical cancer Hela cell proliferation and unobvious inhibiting effect on human ovarian cancer SKOV3 cell proliferation, but ledol has obvious inhibiting effect on human ovarian cancer SKOV3 cell proliferation and unobvious inhibiting effect on human cervical cancer Hela cell proliferation. Camelliene, ledol, gweicurculactone, isorupestonic acid, 7-aromadendrene-6-ketone and 4-aromadendrene can all be used for treating the gynecological tumor.

Description

technical field [0001] The invention belongs to the field of medicine, relates to gynecology, and in particular relates to the application of cinnamon curcumolide in the treatment of gynecological tumors. Background technique [0002] Gynecological tumor is a common and frequently-occurring disease that seriously threatens women's health, and can be divided into benign and malignant. Common gynecological benign tumors include ovarian benign tumors, ovarian tumor-like lesions (simple ovarian cysts and ovarian chocolate cysts, etc.), pelvic inflammatory masses, adenomyosis, and uterine fibroids. The specific methods include surgery, drugs, intervention, etc., among which surgery is the main treatment method, but its damage to ovarian function has been in recent years. has been gradually paid attention to. Traditional Chinese medicine treatment of gynecological benign tumors can control and reduce the tumor size for patients who do not meet the surgical indications, so as to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/045A61K31/015A61K31/122A61K31/19A61P35/00
CPCA61K31/045A61K31/015A61K31/122A61K31/19A61K31/365A61P35/00
Inventor 张长林杨佳
Owner 淮安培元基因科技有限公司
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