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A combination inhibiting meis proteins

A protein, inhibitor technology

Active Publication Date: 2019-07-02
YEDITEPE UNIVSI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even if a suitable donor is found for these transplants, the number of allogeneic HSCs obtained from sources such as umbilical cord blood alone is not sufficient for efficient transplantation

Method used

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  • A combination inhibiting meis proteins
  • A combination inhibiting meis proteins
  • A combination inhibiting meis proteins

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Embodiment Construction

[0023] The present invention is a combination comprising small molecules that inhibit MEIS proteins that are also effective in HSC proliferation ex vivo and in vivo.

[0024] Meis1, Meis2 and Meis3 proteins, which are the MEIS proteins constituting the combination of the present invention, contribute significantly to the stem cell proliferation technique required in stem cell transplantation.

[0025] *The inhibitor disclosed in this specification and constituting the present invention is abbreviated as "MEISi-1", and it means MEIS inhibitor-1.

[0026] *MEISi-2 indicates MEIS inhibitor-2.

[0027] In the accompanying drawings there is given a diagram related to "Combinations for the inhibition of MEIS proteins" which were developed to achieve the object of the present invention, in the accompanying drawings

[0028] figure 1 is a graph of MEISi-1 inhibition of p21-luciferase activity.

[0029] figure 2 is a graph of MEISi-2 inhibition of p21-luciferase activity.

[0030...

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Abstract

The present invention relates to a composition which inhibits MEIS proteins which are effective in proliferation of hematopoietic stem cells. The present invention provides a formulation, which can easily pass through the cell membrane and carry out its activity in the cell, and which can inhibit MEIS activity in a dose dependent manner. Furthermore, the invention can induce ex vivo expansion of mouse, human umbilical cord blood and human bone marrow HSCs. In addition, in vivo application of the invention triggers hematopoietic stem cell expansion in bone marrow and peripheral blood.

Description

[0001] field of invention [0002] The present invention relates to combinations that inhibit MEIS proteins, which are effective in the proliferation of hematopoietic stem cells (HSC). [0003] Background of the invention [0004] The most distinctive features of hematopoietic stem cells (HSCs) are the ability to self-renew and differentiate into multiple cell types. With these capabilities, HSCs can transform into all types of blood cells while maintaining the regenerative capacity required for future hematopoietic activity in the body. Due to the self-renewal ability of HSCs, they are often used in HSC transplantation for the treatment of hematological diseases. However, even if a suitable donor is found for these transplants, the number of allogeneic HSCs obtained from sources such as umbilical cord blood alone is not sufficient for efficient transplantation. Therefore, there is a need to study the ex vivo proliferation of HSCs for such therapeutic applications. Furthermo...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K31/166A61K35/28A61K35/51A61P35/00
CPCA61K38/18A61K35/28A61K35/51A61P35/00A61K31/4152A61K2300/00A61K38/196A61K31/166A61K31/095A61K31/655A61K38/28A61K38/385A61K38/40A61K31/15A61K31/167
Inventor F·科卡巴斯R·D·图兰
Owner YEDITEPE UNIVSI
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