Lumen tissue construction body printing device, printing method thereof and 3D biological printer

Abstract

The invention relates to a lumen tissue construction body printing device, a printing method thereof and a 3D biological printer. The lumen tissue construction body printing device comprises a sprayerhead assembly and a biological printing platform; the sprayer head assembly is used for printing a biological construction body; and the biological printing platform is used for supporting a lumen tissue, bearing the biological construction body printed by the sprayer head assembly and applying the biological construction body to the inner surface of the lumen tissue. According to the lumen tissue construction body printing device, the sprayer head assembly and the biological printing platform are arranged, the sprayer head assembly applies the biological construction body to the inner surface of the lumen tissue through the biological printing platform, the condition that the problems such as thrombus recurrence and lumen restenosis are generated after the lumen tissue is planted for a long time is avoided, and the biological reliability of the lumen tissue is improved.

Description

technical field [0001] The invention relates to the technical field of 3D bioprinting, in particular to a luminal tissue construct printing device, a printing method thereof and a 3D bioprinter. Background technique [0002] In the related art, common artificial blood vessels are made of polymer fibers (such as nylon, polyester), silk or expanded polytetrafluoroethylene. During vascular grafting, diseased or damaged blood vessels can be replaced with complete artificial blood vessels. Although the use of artificial blood vessels to replace diseased or damaged blood vessels has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and lumen restenosis after long-term implantation. The root cause of these problems is the lack of an intact endothelial cell layer on the inner surface of the artificial blood vessel. [0003] In addition, since the artificial blood vessel can hardly be deformed in the radial direction, the relat...

AI Technical Summary

Problems solved by technology

Although the replacement of diseased or damaged blood vessels with this artificial blood vessel has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and the occurrence of lumen restenosis after long-term implantation

The root cause of these problems is the lack of an intact layer of endothelial cells on the inner surface of the artificial blood vessel

[0003] In addition, since the artificial blood vessel can hardly be deformed in the radial direction, related technologies cannot compress the artificial blood vessel externally, so that the biological structure formed by the bio-ink can be completely evenly, completely and flatly attached to the inner wall of the artificial blood vessel

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