Manufacture method of lumen tissue construct

A technology of tissue constructs and manufacturing methods, applied in the field of 3D bioprinting, which can solve problems such as lumen restenosis, artificial blood vessels that cannot be deformed, and lack of endothelial cell layers
CN110614765AActive Publication Date: 2019-12-27SICHUAN REVOTEK CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN REVOTEK CO LTD
Publication Date
2019-12-27

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Abstract

The invention relates to a manufacture method of a lumen tissue construct. The manufacture method includes the steps that firstly, an elastic film is installed on a support in a sleeving manner; thirdly, a biological construct is printed on the elastic film; fifthly, a construct bonding layer is formed on the biological construct; and seventhly, a lumen tissue is bonded on the construct bonding layer. According to the manufacture method of the lumen tissue construct, the printed biological construct is assembled on the inner surface of the lumen tissue to form the lumen tissue construct, and therefore the problems, such as thrombus recurrence and lumen restenosis, caused after the lumen tissue construct is implanted for a long time are avoided, and the biological reliability of the lumen tissue construct is improved.
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Description

technical field

[0001] The invention relates to the technical field of 3D bioprinting, in particular to a method for manufacturing a lumen tissue construct. Background technique

[0002] In the prior art, common artificial blood vessels are made of polymer fibers (such as nylon, polyester), silk or expanded polytetrafluoroethylene. During vascular grafting, diseased or damaged blood vessels can be replaced with complete artificial blood vessels. Although the use of artificial blood vessels to replace diseased or damaged blood vessels has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and lumen restenosis after long-term implantation. The root cause of these problems is the lack of an intact endothelial cell layer on the inner surface of the artificial blood vessel.

[0003] In addition, since the artificial blood vessel can hardly be deformed in the radial direction, the existing technology cannot compress the artif...

Claims

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