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Manufacture method of lumen tissue construct

A technology of tissue constructs and manufacturing methods, applied in the field of 3D bioprinting, which can solve problems such as lumen restenosis, artificial blood vessels that cannot be deformed, and lack of endothelial cell layers

Active Publication Date: 2019-12-27
SICHUAN REVOTEK CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Although the replacement of diseased or damaged blood vessels with this artificial blood vessel has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and the occurrence of lumen restenosis after long-term implantation
The root cause of these problems is the lack of an intact layer of endothelial cells on the inner surface of the artificial blood vessel
[0003] In addition, because the artificial blood vessel can hardly be deformed in the radial direction, the existing technology cannot compress the artificial blood vessel externally so that the bio-brick can be completely evenly, completely and flatly attached to the inner wall of the artificial blood vessel

Method used

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  • Manufacture method of lumen tissue construct
  • Manufacture method of lumen tissue construct
  • Manufacture method of lumen tissue construct

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Embodiment Construction

[0063] The technical solutions of the present invention will be described in further detail below with reference to the accompanying drawings and embodiments.

[0064] The specific embodiments of the present invention are for the convenience of further description of the concept of the present invention, the technical problems to be solved, the technical features constituting the technical solution and the technical effects brought about. It should be noted that the description of these embodiments does not constitute a limitation of the present invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

[0065] In the present invention, the term "biological construct" refers to an artificially constructed two-dimensional or three-dimensional structure containing cells. In certain preferred embodiments, the biological construct is a three-d...

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Abstract

The invention relates to a manufacture method of a lumen tissue construct. The manufacture method includes the steps that firstly, an elastic film is installed on a support in a sleeving manner; thirdly, a biological construct is printed on the elastic film; fifthly, a construct bonding layer is formed on the biological construct; and seventhly, a lumen tissue is bonded on the construct bonding layer. According to the manufacture method of the lumen tissue construct, the printed biological construct is assembled on the inner surface of the lumen tissue to form the lumen tissue construct, and therefore the problems, such as thrombus recurrence and lumen restenosis, caused after the lumen tissue construct is implanted for a long time are avoided, and the biological reliability of the lumen tissue construct is improved.

Description

technical field [0001] The invention relates to the technical field of 3D bioprinting, in particular to a method for manufacturing a lumen tissue construct. Background technique [0002] In the prior art, common artificial blood vessels are made of polymer fibers (such as nylon, polyester), silk or expanded polytetrafluoroethylene. During vascular grafting, diseased or damaged blood vessels can be replaced with complete artificial blood vessels. Although the use of artificial blood vessels to replace diseased or damaged blood vessels has achieved great clinical results, it still faces difficult problems, including the recurrence of thrombus and lumen restenosis after long-term implantation. The root cause of these problems is the lack of an intact endothelial cell layer on the inner surface of the artificial blood vessel. [0003] In addition, since the artificial blood vessel can hardly be deformed in the radial direction, the existing technology cannot compress the artif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/112B29C64/20B29C64/209B29C64/295B29C64/321B29C64/30B29C64/393B29C64/40B33Y10/00B33Y30/00B33Y40/00B33Y50/02
CPCB33Y10/00B33Y30/00B33Y40/00B33Y50/02B29C64/112B29C64/20B29C64/209B29C64/295B29C64/30B29C64/321B29C64/393B29C64/40A61F2/06A61F2240/001B33Y70/00B33Y80/00B29C64/106B29C64/245B29C64/35
Inventor 李意军何峻轩胡小林蒋智左潇
Owner SICHUAN REVOTEK CO LTD
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