Detection method of th gene snp locus associated with opioid dependence and its application
A substance-dependent and opioid-based technology, applied in biochemical equipment and methods, microbiological determination/inspection, etc., can solve problems such as unreported relationship of dependence, achieve accurate typing results, broad application prospects, and rapid genetic analysis. type effect
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[0028] The present invention is further described below with reference to the accompanying drawings and examples, and the examples of the invention are not intended to limit the scope of the invention.
[0029] The present invention analyzes the sequence of the SNP site RS 10770140 to determine the genotype of the TH gene RS 10770140 polymorphic site by extracting the human genomic DNA, and found that the multi-state site is closely related to the OD sensibility of the subject: When the genotype of the TH gene RS10770140 is a C / C homozygous, the subject is the highest inductive; the genotype of the TH gene RS 10770140 polymorphic site is a C / T heterozygate, the susceptibility of the subject Higher; the genotype of the TH gene RS 10770140 polymorphic site is a T / T homogenizer, the subject's susceptibility is the lowest. Based on the above discovery, the present invention proposes an OD high-risk population screening method and screening kit for opioid substance dependent (OD)...
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