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Biological effect-guided self-adaptive radiotherapy system

A biological effect and radiotherapy technology, applied in radiotherapy, therapy, X-ray/γ-ray/particle irradiation therapy, etc., can solve problems such as inability to accurately correct irradiation errors

Active Publication Date: 2019-10-25
ZHONGBEI UNIV
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  • Description
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Problems solved by technology

Because the dose error feedback of the treatment system cannot be directly used to predict the biological effects of the tissue, especially when cells repair and proliferate between fractional irradiations, the traditional offline ART method cannot accurately correct the irradiation of fractionated irradiations error

Method used

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  • Biological effect-guided self-adaptive radiotherapy system
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  • Biological effect-guided self-adaptive radiotherapy system

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Embodiment Construction

[0029] Such as figure 1 As shown, the present invention discloses a bioeffect-guided adaptive radiotherapy system, including an information input module 10, a three-dimensional dose distribution calculation module 20, a deformation field calculation module 30, a cumulative dose distribution calculation module 40, and a biological effect feedback calculation module 50 , treatment plan generation module 60 and information output module 70;

[0030] The information input module 10 is used to input the required data information, wherein the required data information includes the patient's initial three-dimensional density distribution, the patient's three-dimensional density distribution before fractionated irradiation, organ delineation information, treatment head information and completed fractionation irradiation plan;

[0031] The three-dimensional dose distribution calculation module 20 is used to calculate the three-dimensional dose distribution of the completed fractional ...

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Abstract

The invention discloses a biological effect-guided self-adaptive radiotherapy system. The system comprises an information input module, a three-dimensional dose distribution calculation module, a deformation field calculation module, a cumulative dose distribution calculation module, a biological effect feedback calculation module, a treatment plan generation module and an information output module; the information input module isused for inputting required data information,the three-dimensional dose distribution calculation module is used for calculating three-dimensional dose distribution completing fractionated irradiation and calculating the dose distribution of the current fractionated irradiation, the deformation field calculation module is used for calculating a deformation field, the cumulative dose distribution calculation module is used for calculating cumulativedose distribution completing fractionated irradiation, the biological effect feedback calculation module is used for constructing the total dose model,calculatingtotal dose distribution and calculating the biological effect feedback of each organ in a patient, the treatment plan generation module is used for generating a current fractionated irradiation plan, and the information output module is used for outputting the current fractionated irradiationplan. Accordingly, the biological effect feedback is utilized for guiding the fractionated irradiationplan optimizing process, and on the condition that fractionated irradiation has irradiation errors, the influence of repair and multiplication of cells amongfractionated irradiation on the radiotherapy quality is comprehensively considered.

Description

technical field [0001] The invention relates to the technical field of radiotherapy systems, in particular to an adaptive radiotherapy system guided by biological effects. Background technique [0002] Radiation therapy is one of the main means of treating malignant tumors. Clinically, 65%-75% of malignant tumor patients receive radiation therapy at different stages of the disease for different therapeutic purposes. At present, intensity-modulated radiation therapy is one of the commonly used treatment techniques in clinical radiation therapy. This method uses highly conformal rays to irradiate the target area intensively; outside the target area, the irradiation energy drops rapidly to reduce the impact on normal tissues around the target area. The successful application of intensity-modulated radiation therapy technology in clinical radiation therapy mainly depends on the precise irradiation of rays. However, in the course of clinical radiotherapy, it is affected by many...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
CPCA61N5/1031A61N5/1071A61N2005/1052A61N2005/1055
Inventor 张鹏程杨婕桂志国舒华忠张丽媛李杰
Owner ZHONGBEI UNIV
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