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Enhanced solubility of milk thistle extract

An extract, milk thistle technology, applied in the field of enhanced solubility of milk thistle extract, which can solve the problems of insufficient bioavailability/absorbability, hindered compound release rate, etc.

Pending Publication Date: 2020-05-05
EUROMED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This solubility profile hampers the release rate of these compounds and thus their bioavailability / absorbability in humans or mammals is insufficient

Method used

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  • Enhanced solubility of milk thistle extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0122] Embodiment 1: Disclosed herein is a potent milk thistle extract obtained by:

[0123] (a) providing an oily milk thistle extract obtained by defatting milk thistle fruit;

[0124] (b) placing the oily extract from (a) in an organic solvent to form a solution;

[0125] (c) providing an additional extract from defatted milk thistle fruit, wherein the additional extract is obtained by washing said defatted milk thistle fruit with a solvent and subsequently removing said solvent;

[0126] (d) placing the additional extract from (c) in a solvent to form a solution;

[0127](e) combining the solution of (b) with the solution of (d) to form a combined extract solution such that the amount of the oily extract from (a) in the final product of (f) is 0.5% to 10.0% by weight %;

[0128] (f) removing the solvent of the combined extract solution of (e) to obtain a solid, and optionally comminuting said solid;

[0129] Among them, the product has a silymarin release rate of 90% o...

Embodiment approach 2

[0130] Embodiment 2: The product according to embodiment 1, wherein the solution of (b) is concentrated and / or filtered.

Embodiment approach 3

[0131] Embodiment 3: The product according to embodiment 1 or 2, wherein the solution of (d) is concentrated and / or filtered.

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Abstract

Described herein is a method for the production of a potent milk thistle extract. The method involves adding oil to the milk thistle extract leading to an increase in the release rate of the plant drug. Also described herein is a product obtained by a method for the production of a potent milk thistle extract and the uses of said product.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 562,293, filed September 22, 2017, which is incorporated herein by reference. Background technique [0003] The efficacy of the drug silymarin extracted from the fruit of milk thistle in the treatment and prevention of various forms of liver and gallbladder dysfunction is known. For the general preparation of milk thistle extracts, after the initial defatting of milk thistle fruit, the botanical drug (silymarin) is extracted, purified and dried. The flavonolignans comprising this botanical drug are known to have little or no solubility in water. This solubility profile hampers the release rate of these compounds and thus their bioavailability / absorbability in humans or mammals is insufficient. Contents of the invention [0004] This document discloses a potent milk thistle extract obtained by: [0005] (a) providing an oily milk thistle extr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28
CPCA61K2236/00A61K36/28A23L33/105A61K2236/10A61K2236/35A23V2002/00A23V2300/00A23V2300/14A61K9/0053A61K2236/17A61K2236/333A61K2236/51
Inventor 圣地亚哥·鲁尔普鲁斯安娜·穆拉达尔特尔奥古斯汀·比利亚尔冈萨雷斯
Owner EUROMED
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