Adenovirus vector and application thereof in preparation of medicine for preventing and treating heart failure

Abstract

The invention discloses a medicine for preventing and treating heart failure, which is characterized in that the medicine for preventing and treating heart failure comprises an adenovirus vector, theadenovirus vector comprises a polynucleotide sequence for encoding HSF1, and the polynucleotide sequence of HSF1 is shown as SEQ ID NO: 1. The HSF1 promotes cardiac angiogenesis by inhibiting p53 andthen up-regulating HIF-1 in endothelial cells during chronic pressure overload, so that cardiac adaptability is maintained, and the adenovirus vector has important significance in early prevention andtreatment of heart failure and further research and development of related drugs and means.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to an adenovirus vector and its application in the preparation of drugs for preventing and treating heart failure. Background technique [0002] Heart failure is a group of complex clinical syndromes, which is a serious stage for most patients with organic heart disease, and the 5-year survival rate is similar to that of malignant tumors. Once heart failure occurs in heart patients, the 1-year mortality rate is 43%, and the 5-year mortality rate reaches 75%, seriously endangering human health. Epidemiological data show that the number of heart failure patients in the world is as high as 22.5 million, and there are 2 million new cases every year. The rapid aging of the population and the increase of various risk factors make ischemic heart disease the most common cause of heart failure. In developed countries, the increase in the survival rate of myocardial infarction...

AI Technical Summary

Problems solved by technology

However, the current treatment methods for heart failure are all palliative treatments for damaged or necrotic myocardium, and the degree of recovery is limited.

Images