Device for producing fingolimod

Abstract

The invention discloses a device for producing fingolimod, and relates to the field of devices for producing the fingolimod. According to the technical solution, the device is mainly characterized bycomprising a reaction box; a first opening distributed between through pipes is formed in the bottom wall of the reaction box; the ends, away from the first opening of the through pipes rotationally communicate with a disposal box; the inner wall of the disposal box is hinged with a telescopic rod; one end of the telescopic rod is hinged with a U-shaped frame; the side wall, away from the telescopic rod, of the U-shaped frame is fixedly connected with a moving rod; the moving rod is provided with a first driving member driving the moving rod to drive the U-shaped frame to move; the inner wallof the U-shaped frame is provided with a filter screen; the upper end wall of the reaction box is in threaded connection with a second screw extending into the reaction box; the end, extending into the reaction box, of the second screw is provided with rotating blades; the end, far away from the rotating blades, of the second screw is connected with an L-shaped rod; and one end of the L-shaped rodis provided with a second driving member driving the L-shaped rod to move in the length direction of the second screw.

Description

technical field [0001] The present invention relates to the field of devices for producing fingolimod, more specifically, it relates to a device for producing fingolimod. Background technique [0002] Fingolimod is a receptor modulator and is mainly used clinically for the treatment of relapsing-remitting multiple sclerosis. [0003] The Chinese patent with the notification number CN104193626A discloses the preparation method of fingolimod granules, (a) adding ethyl acetate to the reactor, controlling the temperature at -5°C-5°C, feeding ethyl acetate and fingolimod hydrochloride The mass ratio of the amount is 20:1-32:1 (b) dissolve fingolimod hydrochloride in ethanol at 35°C, the mass ratio of fingolimod hydrochloride to ethanol is 1:4 (c) dissolve the solution of step b Add it dropwise to the solution in step a, control the stirring speed of the ethyl acetate mixture to 200rpm-300rpm, and control the temperature of the ethyl acetate mixture to be 0°C-5°C (d) Stir and cr...

AI Technical Summary

Problems solved by technology

[0004] However, stirring fingolimod crystallization and stirring and filtering of fingolimod particles are performed step by step, which is not efficient

Images