Adhesion chromosome separation method and device based on skeleton segmentation and key point detection

A separation method and chromosome technology, applied in the field of chromosome analysis, can solve problems such as unsatisfactory performance, and achieve the effect of good generalization ability

Active Publication Date: 2021-01-08
SHANDONG IND TECH RES INST OF ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods are limited to some specific situations, and the performance is not satisfactory.
In recent years, some deep learning methods have been used to separate cohesive ch

Method used

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  • Adhesion chromosome separation method and device based on skeleton segmentation and key point detection
  • Adhesion chromosome separation method and device based on skeleton segmentation and key point detection
  • Adhesion chromosome separation method and device based on skeleton segmentation and key point detection

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Experimental program
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Effect test

Embodiment 1

[0035] Embodiment one, such as figure 1 Shown:

[0036] S1. Scale and normalize the cohesive chromosome image to be separated to obtain the cohesive chromosome input image.

[0037] Specifically, firstly, adjust the size of the cohesive chromosome image to be separated to the set value, m × n; we use m=n=128, so that the length and width of the image of cohesive chromosomes become 128 pixels, and the method of bilinear interpolation is adopted for cohesive chromosomes when expanding.

[0038] Then, normalize the size-adjusted cohesive chromosome image, that is, use the standard deviation normalization results obtained by formulas (1)-(4):

[0039] (1):

[0040] (2):

[0041] (3):

[0042] (4):

[0043] Where μ is the average value of pixels in all images, σ is the standard deviation of pixel values ​​in all images, and x i is the i-th pixel value in the image, is the i-th pixel value after normalization processing, is the final pixel value of the i-th pixel ...

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PUM

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Abstract

The invention belongs to the technical field of chromosome analysis, and particularly relates to an adhesion chromosome separation method and device based on skeleton segmentation and key point detection. The adhesion chromosome separation method based on skeleton segmentation and key point detection comprises the following steps: S1, scaling and normalizing an adhesion chromosome image to be separated to obtain an adhesion chromosome input image; and S2, inputting the adhesion chromosome input image obtained in the step S1 into a chromosome skeleton segmentation model for segmentation to obtain a chromosome skeleton image. The method provided by the invention does not depend on a specific morphological mode of chromosomes, has relatively high generalization ability, starts from adhesion points among the adhesion chromosomes, and utilizes the adhesion points to separate the adhesion chromosomes. The adhesion chromosome separation method and device based on skeleton segmentation and keypoint detection can effectively solve the chromosome separation problem during adhesion of multiple chromosomes.

Description

technical field [0001] The invention belongs to the technical field of chromosome analysis, in particular to a method and device for separating cohesive chromosomes based on skeleton segmentation and key point detection. Background technique [0002] Chromosomal analysis can be seen from the karyotype map to see changes in number or structure, which is an important basis for judging chromosomal aberrations. However, chromosomes are not rigid objects and their positions are random, and two or more chromosomes may be cross-bonded. Extracting chromosomes from these contact-adhesive chromosomes is a very tedious process. [0003] For cohesive chromosomes, the traditional segmentation methods mostly separate different cohesive chromosomes by using geometric shapes, curvature of chromosome boundaries, and chromosome layout, and there are also techniques based on splitting and merging and watershed to separate cohesive chromosomes. However, these methods are limited to some speci...

Claims

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Application Information

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IPC IPC(8): G06T7/10G06T3/40
CPCG06T7/10G06T3/4007G06T2207/20081G06T2207/20084
Inventor 吴健余柏翰项阳彭凯
Owner SHANDONG IND TECH RES INST OF ZHEJIANG UNIV
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