Method of performing differential diagnosis of neurodegenerative diseases in a subject

A neurodegenerative, subject-based technology, applied in disease diagnosis, medical automated diagnosis, biological testing, etc., can solve the problems of not helping to improve the living conditions of patients, mixed dementia can not be well treated, etc.

Pending Publication Date: 2021-03-26
ALZOHIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Mixed dementias are also poorly treated as patients are often only diagnosed with a single type of dementia
In such cases, doctors will base their medication decisions / prescriptions on the type of dementia that has been diagnosed and ultimately will not help improve the patient's life situation

Method used

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  • Method of performing differential diagnosis of neurodegenerative diseases in a subject
  • Method of performing differential diagnosis of neurodegenerative diseases in a subject
  • Method of performing differential diagnosis of neurodegenerative diseases in a subject

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Experimental program
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Embodiment Construction

[0068] specific implementation plan

[0069] The present invention allows the development of effective differential diagnosis methods.

[0070] The diseases diagnosed as a result of the method of the present invention are the following neurodegenerative diseases: Alzheimer's disease (AD), psychotic depression (PSY), amyotrophic lateral sclerosis (ALS), frontotemporal dementia ( FTD), Parkinson's disease (PD), progressive supranuclear palsy (PSP), and Parkinson's disease with dementia (PD+). The diagnosis is able to distinguish which neurodegenerative disease a patient has. The diagnostic method of the present invention can obviously also differentiate between healthy patients (CTRL or controls).

[0071] exist figure 1 Above, for simplicity, only AD and PSY are described. The rest of the study diseases were included in the reference OD (other diseases). This is because in these diseases the number of subjects in the training model step is less than 15 subjects (see also ...

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Abstract

The invention is directed to an in vitro method for performing a differential diagnosis of neurodegenerative diseases in a subject, said subject being selected among subjects suffering from Alzheimer's disease, mental depression, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, progressive supranuclear palsy, and / or Parkinson's disease with dementia. Said method comprises the steps of: (a) determining at least five criteria of said subject, (b) comparing said at least five criteria of said subject with reference values by calculating a global note in relation with each neurodegenerative disease, and (c) determining whether said subject suffers from Alzheimer's disease, mental depression, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, progressive supranuclear palsy, Parkinson's disease with dementia or mixed dementia.

Description

[0001] manual technical field [0002] The present invention relates to methods for differential diagnosis of neurodegenerative diseases in a subject. Background technique [0003] Making a differential diagnosis allows the clinician to triage the patient, who then has the opportunity to receive appropriate treatment to cure or at least improve his / her medical condition. [0004] Neurodegenerative diseases characterized by progressive loss of structure or function of neurons are numerous, as shown in the following list: Alzheimer's disease, depression, amyotrophic lateral sclerosis, frontotemporal dementia, Kimson's disease, progressive supranuclear palsy, Parkinson's disease with dementia, etc. [0005] The boundaries between these diseases are sometimes difficult to distinguish, so clinicians responsible for patient follow-up will hesitate and treat a patient inappropriately. The diagnosis is also difficult to establish in the sense that it implies expensive and tedious ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/94G16H50/20
CPCG01N33/6896G01N33/9413G01N33/9433G01N2800/2821G01N2800/2835G16H10/20G16H50/20G01N2800/28G16H10/40
Inventor R.维皮洛特H.蒂里兹
Owner ALZOHIS
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