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Method of performing differential diagnosis of neurodegenerative diseases in subject

A neurodegenerative, subject technology, applied in the fields of disease diagnosis, psychotherapy, medical automation diagnosis, etc., can solve the problems of mixed dementia that cannot be well treated and can not help improve the living conditions of patients.

Pending Publication Date: 2021-07-23
ALZOHIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Mixed dementias are also poorly treated as patients are often only diagnosed with a single type of dementia
In such cases, doctors will base their medication decisions / prescriptions on the type of dementia that has been diagnosed and ultimately will not help improve the patient's life situation

Method used

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  • Method of performing differential diagnosis of neurodegenerative diseases in subject
  • Method of performing differential diagnosis of neurodegenerative diseases in subject
  • Method of performing differential diagnosis of neurodegenerative diseases in subject

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Experimental program
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Embodiment Construction

[0153] specific implementation plan

[0154] The present invention allows the development of effective differential diagnosis methods.

[0155] The diseases diagnosed as a result of the method of the invention are the following neurodegenerative diseases: Alzheimer's disease with a norepinephrine concentration [NA] between 3000 pmol / l and 15000 pmol / l (AD1), norepinephrine Alzheimer's disease, psychotic depression (PSY), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD) and / or epinephrine concentration [NA] between 100 pmol / l and 2700 pmol / l (AD2) or vascular dementia (VD). The diagnosis is able to distinguish which neurodegenerative disease a patient has. The diagnostic method of the present invention also clearly distinguishes patients with mild cognitive impairment. These patients often present with cognitive problems, anxiety, burnout, sleep apnea, and alcohol abuse. They are called control patients or neuro control patients (Control / CTRL / NeuroControl / Neur...

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Abstract

The invention is directed to an in vitro method for performing a differential diagnosis of neurodegenerative diseases in a subject, said subject being selected among subjects suffering from Alzheimer's disease, mental depression, dementia with Lewy Body, frontotemporal dementia, and / or vascular dementia. Said method comprises the steps of: (a) determining at least five criteria of said subject, (b) comparing said at least five criteria of said subject with reference values by calculating a global note in relation with each neurodegenerative disease, and (c) determining whether said subject suffers from Alzheimer's disease, mental depression, dementia with Lewy Body, frontotemporal dementia, vascular dementia or mixed dementia.

Description

[0001] manual technical field [0002] The present invention relates to methods for differential diagnosis of neurodegenerative diseases in a subject. Background technique [0003] Making a differential diagnosis allows the clinician to triage the patient, who then has the opportunity to receive appropriate treatment to cure or at least improve his / her medical condition. [0004] Neurodegenerative diseases characterized by progressive loss of structure or function of neurons are numerous, as shown in the following list: Alzheimer's disease, depression, amyotrophic lateral sclerosis, frontotemporal dementia, Kimson's disease, progressive supranuclear palsy, Parkinson's disease with dementia, dementia with Lewy bodies, vascular dementia, etc. [0005] With regard to Alzheimer's disease, it has been noted that elevated norepinephrine concentrations may be the cause in some patients (Fitzgerald P.J., Current Alzheimer Research, 2010, 7, 506-516). [0006] The boundaries betwee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/94G16H50/20
CPCG16H50/20G01N33/6896G01N33/9413G01N33/9433G01N2800/2814G01N2800/2821G16H10/20G16H50/30G16H20/70
Inventor R.弗皮洛特H.蒂里兹
Owner ALZOHIS
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