Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Construction method of autism animal model and corresponding application

An animal model and technology of autism, applied in the field of medical research, can solve problems such as inability to respond to full-spectrum immune responses

Pending Publication Date: 2021-06-29
NANJING MEDICAL UNIV
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although these two preparations can induce the activation of the body's innate immunity, they have t

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Construction method of autism animal model and corresponding application
  • Construction method of autism animal model and corresponding application
  • Construction method of autism animal model and corresponding application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The solutions of the present invention will be explained below in conjunction with examples. Those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be considered as limiting the scope of the present invention. If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products. The experimental methods used are conventional methods unless otherwise specified.

[0022] In order to solve the problems of the prior art, the present invention focuses on a serious opportunistic pathogenic protozoan parasitic in nucleated cells of humans and warm-blooded animals - Toxoplasma gondii, because it is generally susceptible in...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a construction method of an animal model for characterizing autism (children autism and autism) and application, and belongs to the field of medical animal model research. The construction method specifically comprises the steps that a soluble compound of toxoplasma gondii tachyzoites is prepared through purification and injected into pregnant experimental animals, and the obtained progeny is an autism animal model and has one or more of social communication disorders, repeated engraving behaviors or common accompanying anxiety symptoms of autism. The constructed animal model can be widely applied to autism mechanism research and screening, research and development of autism-related drugs.

Description

technical field [0001] The present invention relates to the field of medical research, in particular to a method for preparing a soluble compound of toxoplasma gondii, a method for using the compound to construct an animal model of autism, and a method for screening drugs for treating autism using the animal model and application. Background technique [0002] Autism is a neurodevelopmental spectrum disorder that belongs to mental illness. The etiology and pathological mechanism of the disease are very complex, and the core symptoms are social communication impairment, language communication impairment and repetitive stereotyped behavior. It is generally believed that autism is caused by environmental, biological (infection) and genetic factors, but the specific pathogenic mechanism has not been fully elucidated. At present, people's research and screening of drugs for autism are mainly based on animal models of autism, but so far no effective drugs targeting core symptoms ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01K67/02A61K31/4985A61K31/4439A61P25/00C12N1/10C12N1/02C12N1/06C12R1/90
CPCA01K67/02C12N1/10C12N1/02C12N1/066A61K31/4985A61K31/4439A61P25/00A01K2227/105A01K2267/0356A01K2207/20
Inventor 徐志鹏季旻珺周子凯张小云
Owner NANJING MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com