Biomarker for detecting thrombus or blood coagulation related diseases and application thereof

A biomarker and marker technology, applied in the field of detection of thrombus or coagulation-related diseases, can solve problems such as low sensitivity and specificity, difficulty in confirming whether a new thrombus appears, and inability to reflect the coagulation status in the body in a timely and accurate manner. Improve the sensitivity and specificity, improve the detection rate, and the effect of good detection effect

Pending Publication Date: 2021-09-03
YIGONG RUISI FUJIAN ENG RES CENT CO LTD
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coupled with its shortcomings of low sensitivity and specificity, the application of D-dimer is still controversial
In addition, the test results lack the meaning of treatment guidance, and cannot timely and accurately reflect the coagulation sta

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biomarker for detecting thrombus or blood coagulation related diseases and application thereof
  • Biomarker for detecting thrombus or blood coagulation related diseases and application thereof
  • Biomarker for detecting thrombus or blood coagulation related diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1-1

[0053] A biomarker for detection of thrombosis or coagulation-related diseases: FXIIIAP coagulation factor 13 activating peptide.

Embodiment approach 1-2

[0055] A biomarker for detection of thrombosis or coagulation-related diseases: FXIIIA (subunit A of coagulation factor 13).

Embodiment approach 1-3

[0057] A biomarker for detecting thrombosis or coagulation-related diseases: it is a combination of FXIIIAP and FXIIIA.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of thrombus or blood coagulation related disease detection, in particular to a biomarker and application thereof in thrombus or blood coagulation related disease detection. The marker comprises a blood coagulation factor 13 activating peptide (FXIIIAP) or/and a blood coagulation factor 13 A subunit (FXIIIA). The detection kit provided by the invention comprises a capture antibody and a detection antibody, and is a specific antibody prepared by taking FXIIIAP as an antigen. The biomarker disclosed by the invention has a good application prospect in the aspect of quickly screening and diagnosing thrombus or blood coagulation related diseases including cerebral apoplexy, can greatly improve the sensitivity and specificity of existing diagnosis, speculates the thrombus formation time and degree, and can predict the severity and prognosis of the diseases.

Description

technical field [0001] The invention relates to the technical field of detection of thrombus or coagulation-related diseases, in particular to a biomarker for detecting thrombus or coagulation-related diseases and its application. Background technique [0002] Thrombosis and related coagulation diseases have always been important diagnostic items in clinical diagnosis, involving a wide range of diseases, including cerebral venous thrombosis (CVT), renal vein thrombosis (RVT), venous thrombosis (VTE), myocardial infarction (MI), etc. . Among them, the early diagnosis and early treatment of cerebral venous thrombosis and myocardial infarction are particularly important. Taking cerebral venous thrombosis (an important cause of ischemic stroke) as an example, the existing diagnostic methods mainly include computed tomography (CT) and magnetic resonance imaging (MRI), which are very effective in judging the occurrence, type and severity of stroke. efficient. However, these tec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N33/68
CPCG01N33/86G01N33/6893G01N2800/224G01N2800/226G01N2800/324G01N2800/2871G01N2333/745
Inventor 林哲
Owner YIGONG RUISI FUJIAN ENG RES CENT CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap