Biomarker for regulating CD4 + T cell differentiation and proliferation of type 1 diabetes mellitus and application thereof

A type 1 diabetes and biomarker technology, applied in the field of biomedicine, can solve the problems of not being able to provide T1DM intervention targets and timing, and achieve multi-possible effects

Pending Publication Date: 2022-01-14
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Therefore, antibody positive is only meaningful for the diagnosis of T1DM, but it cannot provide the intervention target and timing of T1DM

Method used

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  • Biomarker for regulating CD4 + T cell differentiation and proliferation of type 1 diabetes mellitus and application thereof
  • Biomarker for regulating CD4 + T cell differentiation and proliferation of type 1 diabetes mellitus and application thereof
  • Biomarker for regulating CD4 + T cell differentiation and proliferation of type 1 diabetes mellitus and application thereof

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Experimental program
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Embodiment

[0019] The T1DM patients (experimental group) in this example were all inpatients in the Department of Endocrinology and Metabolism of the Affiliated Hospital of Qingdao University. The control group was healthy volunteers from the Health Examination Center of the Affiliated Hospital of Qingdao University. All subjects in the control group were excluded from the history of autoimmune diseases. and family history, the study was approved by the Ethics Committee of the Affiliated Hospital of Qingdao University and conducted in accordance with the principles of the Declaration of Helsinki.

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Abstract

The invention relates to the field of biomedicine, and discloses a biomarker for regulating CD4 + T cells differentiation and proliferation of type 1 diabetes mellitus, which comprises circRNA000324; the invention also discloses an application thereof. According to the invention, a new target is provided for the mechanism research of T1DM autoimmunity, a new evidence is provided for the action mechanism of non-encoding RNA (ncRNA) and related ceRNAs networks in T1DM pathogenesis, and more possibilities are provided for predicting or preventing and treating type 1 diabetes mellitus.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a biomarker for regulating the differentiation and proliferation of CD4+ T cells in type 1 diabetes and its application. Background technique [0002] Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by autoreactive T cell-mediated destruction of pancreatic β-cells and insulin dysfunction, despite significant advances in research on T1DM in recent decades , but the specific mechanism of T1DM autoimmunity has not been fully determined. Although combined antibody testing including GADA, IA-A2, and ZnT8A is currently available, there are still many patients with clinical features consistent with T1DM who are negative for antibodies, and positive antibody testing in T1DM immediate relatives indicates the presence of T1DM. High-risk, immune interventions designed to target these antibodies have so far had no success. Therefore, antibody positive is onl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/6851C12Q1/6883A61K45/00A61P3/10
CPCC12N15/113C12Q1/6851C12Q1/6883A61K45/00A61P3/10C12Q2600/158C12Q2600/178C12Q2531/113C12Q2563/107
Inventor 李树法
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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