Magnetic contrast medium composition and its preparing method

A contrast agent and composition technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve problems such as difficult medical examination, unstable finished product, complicated process, etc., achieve strong anti-magnetic coagulation, good anti-absorption, good safety effect

Inactive Publication Date: 2004-03-10
山东省医学影像学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also used as a gastrointestinal contrast agent for oral use, but its finished product is unstable, easily oxidized, and precipitates after a few hours. It can only be temporarily prepared when taking it. for medical examination

Method used

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  • Magnetic contrast medium composition and its preparing method
  • Magnetic contrast medium composition and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0044] Chinese medicine magnet 0.6g, Tween-80 19g, gum arabic 4g, agar 5g, 4-hydroxy-3-methoxybenzoic acid 0.2g, potassium tripolyphosphate 0.3g, add deionized water to 1000g.

[0045] The above preparation presents a dark gray homogeneous liquid with a viscosity of 0.6 Pa.s, a specific gravity of 1.2, and a pH value of 6.8, and each sequence of MR scans shows low signal.

example 2

[0047] Ferric oxide 0.3g, linoleic acid 10g, cyclodextrin 3g, xanthan gum 4g, 4-hydroxy-3-methoxybenzoic acid 0.2g, EDTA 0.3g, add deionized water to 1000g.

[0048] The above preparation is a light gray homogeneous liquid with a viscosity of 0.3 Pa.s, a specific gravity of 1.12, and a pH value of 6.5. The MR scans show low signal.

example 3

[0050] Ferric oxide 0.9g, Tween-80, 20g, gum arabic 4g, cyclodextrin 5g, 4-hydroxy-3-methoxybenzoic acid 0.1g, brain oil 0.2g, EDTA 0.4g, plus deionized Water to 1000g.

[0051] The above preparation is an orange homogeneous liquid with a viscosity of 0.8 Pa.s, a specific gravity of 1.22, and a pH value of 6.5. The MR scans show low signal.

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Abstract

A magnetic contrast medium composite for nuclear magnetic resonance image diagnosis has magnetite and other magnetic matters as main raw materials. Magnetic material is powdered into 2-20 micron fine pwoder, and mixed with surfactant, stabilizer, excipient, chelating agent, corrective and other assistant; and the mixutre is further processed through surface shaping, dispersing and homogenization to produce a stable and homogeneous mixture suspension used as contrast medium for the nuclear magnetic resonance inspection of gastrointestinal tract and its peripheral tissue. The constrast medium is safe and absorption resistant, can be used to fill gastrointestinal tract continuously and has excellent usage effect. The present invention makes it possible to raise diagnosis level and expand the application range of nuclear magnetic resonance.

Description

Technical field: [0001] The present invention relates to preparations for medical examinations, and more particularly to a production technique for a chemical used in nuclear magnetic resonance medical examinations. Background technique: [0002] With the characteristics of high resolution and multi-parameter imaging, nuclear magnetic resonance is widely used in clinical medicine and has become an important means of imaging examination. However, due to the tortuosity, overlapping and enveloping of the human gastrointestinal tract, self-peristalsis, poor natural contrast, and long MRI imaging time, it greatly affects the application of MRI in gastrointestinal and abdominal examinations. To a large extent, it restricts the application of magnetic resonance in the gastrointestinal tract and abdomen. Therefore, improving the resolution of MRI gastrointestinal imaging can improve the diagnosis of gastrointestinal lesions and help to assist in the display of surrounding and retro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 姚建赵斌桂维玲刘强
Owner 山东省医学影像学研究所
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