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Agonists of Tacr2

An agonist, 1. tacr2 technology, used in the treatment of obesity and/or diabetes, in the field of increasing glucose and energy expenditure in individuals, to address problems such as decreased enthusiasm, increased blood pressure and heart rate

Pending Publication Date: 2022-06-07
UNIVERSITY OF COPENHAGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug can cause increases in blood pressure and heart rate, undesirable side effects in potentially obese patients, reducing enthusiasm for this therapeutic avenue

Method used

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  • Agonists of Tacr2
  • Agonists of Tacr2
  • Agonists of Tacr2

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Experimental program
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Embodiment Construction

[0020] definition

[0021] As used herein, the term "agonist" refers to an agonist of Tacr2 unless specifically stated otherwise. An agonist of Tacr2 as defined herein refers to a compound comprising a peptide that can bind to Tacr2 to enhance its activity or a compound consisting of a peptide that can bind to Tacr2 to enhance its activity.

[0022] As used herein, the term "activity of brown and / or beige adipose tissue cells" such as "activity of brown and / or beige adipose tissue" refers to a number of biochemical parameters typical of cells of brown and beige adipose tissue that can respond to interaction between Tacr2 and agonists. Some examples of parameters that define brown and / or beige adipocyte activity are basal oxygen consumption rate (OCR), norepinephrine (NE)-induced OCR, maximal respiration, glucose uptake / absorption, lipid uptake / absorption, heat production .

[0023] Proteinogenic "amino acids" are designated herein using their one-letter codes (according to ...

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Abstract

The present disclosure relates to agonists of Tacr2, e.g., peptide agonists of Tacr2, and methods of using the same for the treatment of insulin resistance, obesity, and / or diabetes. The present disclosure also relates to the use of said Tacr2 agonists for increasing the energy consumption in an individual.

Description

[0001] Field of Invention [0002] The present disclosure relates to agonists of Tacr2, such as peptide agonists of Tacr2, and methods of using the same for the treatment of obesity and / or diabetes. The disclosure also relates to the use of the agonists of Tacr2 for increasing glucose and energy expenditure in an individual. [0003] Background of the Invention [0004] There are approximately 2 billion overweight or obese individuals and 350 million diabetic individuals in the world (according to the World Health Organization), and despite ongoing research, there is still a need for effective treatments. [0005] One of the therapeutic strategies investigated is the activation of brown adipose tissue and beige / brite adipose tissue. Classical activation of brown and beige adipose tissue by norepinephrine (NE) increases the energy expenditure of these cells through beta-adrenergic receptors (β3AR) (Cannon and Nedergaard, 2004). One of the main effectors of energy expenditure i...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K38/10A61K38/16A61K47/54A61P3/04A61P3/10A61P5/50
CPCA61K38/08A61K38/10A61P3/04A61P3/10A61P5/50C07K7/22A61K47/549A61K47/542
Inventor Z·格哈特-海因斯J·B·汉森T·W·施瓦兹
Owner UNIVERSITY OF COPENHAGEN
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