Agonists of Tacr2

An agonist, 1. tacr2 technology, used in the treatment of obesity and/or diabetes, in the field of increasing glucose and energy expenditure in individuals, to address problems such as decreased enthusiasm, increased blood pressure and heart rate

Pending Publication Date: 2022-06-07
UNIVERSITY OF COPENHAGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drug can cause increases in blood pressure and heart rate, undesirable sid

Method used

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  • Agonists of Tacr2
  • Agonists of Tacr2
  • Agonists of Tacr2

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Experimental program
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Embodiment Construction

[0020] definition

[0021] As used herein, the term "agonist" refers to an agonist of Tacr2 unless specifically stated otherwise. An agonist of Tacr2 as defined herein refers to a compound comprising a peptide that can bind to Tacr2 to enhance its activity or a compound consisting of a peptide that can bind to Tacr2 to enhance its activity.

[0022] As used herein, the term "activity of brown and / or beige adipose tissue cells" such as "activity of brown and / or beige adipose tissue" refers to a number of biochemical parameters typical of cells of brown and beige adipose tissue that can respond to interaction between Tacr2 and agonists. Some examples of parameters that define brown and / or beige adipocyte activity are basal oxygen consumption rate (OCR), norepinephrine (NE)-induced OCR, maximal respiration, glucose uptake / absorption, lipid uptake / absorption, heat production .

[0023] Proteinogenic "amino acids" are designated herein using their one-letter codes (according to ...

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PUM

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Abstract

The present disclosure relates to agonists of Tacr2, e.g., peptide agonists of Tacr2, and methods of using the same for the treatment of insulin resistance, obesity, and/or diabetes. The present disclosure also relates to the use of said Tacr2 agonists for increasing the energy consumption in an individual.

Description

[0001] Field of Invention [0002] The present disclosure relates to agonists of Tacr2, such as peptide agonists of Tacr2, and methods of using the same for the treatment of obesity and / or diabetes. The disclosure also relates to the use of the agonists of Tacr2 for increasing glucose and energy expenditure in an individual. [0003] Background of the Invention [0004] There are approximately 2 billion overweight or obese individuals and 350 million diabetic individuals in the world (according to the World Health Organization), and despite ongoing research, there is still a need for effective treatments. [0005] One of the therapeutic strategies investigated is the activation of brown adipose tissue and beige / brite adipose tissue. Classical activation of brown and beige adipose tissue by norepinephrine (NE) increases the energy expenditure of these cells through beta-adrenergic receptors (β3AR) (Cannon and Nedergaard, 2004). One of the main effectors of energy expenditure i...

Claims

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Application Information

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IPC IPC(8): A61K38/08A61K38/10A61K38/16A61K47/54A61P3/04A61P3/10A61P5/50
CPCA61K38/08A61K38/10A61P3/04A61P3/10A61P5/50C07K7/22A61K47/549A61K47/542
Inventor Z·格哈特-海因斯J·B·汉森T·W·施瓦兹
Owner UNIVERSITY OF COPENHAGEN
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