Cannabidiol-containing gel as well as preparation method and application thereof

Abstract

The invention discloses gel containing cannabidiol as well as a preparation method and application of the gel. The gel containing cannabidiol is prepared from the following components in parts by weight: 0.1 to 0.5 part of cannabidiol, 0.1 to 0.5 part of herba selaginellae extract, 0.1 to 0.5 part of radix sanguisorbae extract, 20 to 40 parts of natural gel, 1 to 5 parts of natural pigment, 10 to 15 parts of coloring agent, 1 to 3 parts of polyvinylpyrrolidone, 5 to 10 parts of humectant and 0.1 to 0.4 part of pH (Potential of Hydrogen) regulator. The gel is excellent in antibacterial, anti-inflammatory and moisturizing effects, and has a relatively good repairing effect on facial laser wounds. Meanwhile, the gel can present abundant and stable colors, can present a good color development effect while repairing the facial laser wound, and meets the aesthetic needs of consumers when using the facial laser wound repairing product. Furthermore, the components of the gel are mainly from natural raw materials, so that the use safety is good. In addition, the gel preparation method is simple and easy to implement and convenient to popularize.

Description

Technical Field

[0001] The present invention relates to the technical field of gel, and in particular to a gel containing cannabidiol, and a preparation method and application thereof. Background Art

[0002] With the continuous development of medical cosmetic technology, facial laser treatment has become a common cosmetic method. However, facial laser treatment is prone to leave trauma on the face. In order to obtain effective laser treatment effects, the trauma needs to be effectively repaired.

[0003] There are many types of facial laser trauma repair products on the market, and most of them may have a certain repair effect on facial laser trauma. These repair products often need to be applied to the facial trauma during use, which will have an adverse effect on the consumer's facial beauty and is difficult to meet the consumer's aesthetic needs. Summary of the invention

[0004] Based on the above problems, the present invention provides a gel containing cannabidiol, a preparation method and application thereof. The gel containing cannabidiol has excellent antibacterial, anti-inflammatory and moisturizing effects, and has a good repair effect on facial laser trauma. At the same time, the gel containing cannabidiol can present rich and stable colors, can show good color rendering effects while repairing facial laser trauma, and meet the aesthetic needs of consumers when using facial laser trauma repair products.

[0005] To achieve the above object, the present invention adopts the following technical solutions: A gel containing cannabidiol comprises the following components in parts by weight: 0.1-0.5 parts of cannabidiol, 0.1-0.5 parts of Selaginella extract, 0.1-0.5 parts of Sanguisorba officinalis extract, 20-40 parts of natural gel, 1-5 parts of natural pigment, 10-15 parts of colorant, 1-3 parts of polyvinyl pyrrolidone, 5-10 parts of moisturizer and 0.1-0.4 parts of pH adjuster; the mass ratio of the cannabidiol, the Selaginella extract and the Sanguisorba officinalis extract is (2-4):(1-3):(1-3).

[0006] In some embodiments, the cannabidiol-containing gel includes the following components in parts by weight: 0.2-0.4 parts of cannabidiol, 0.1-0.3 parts of Selaginella extract, 0.1-0.3 parts of Sanguisorba officinalis extract, 25-35 parts of natural gel, 1.5-3.5 parts of natural pigment, 11-13 parts of colorant, 1.5-2.5 parts of polyvinyl pyrrolidone, 7-9 parts of moisturizer and 0.15-0.3 parts of pH adjuster.

[0007] In some embodiments, the pH value of the cannabidiol-containing gel is 6.5-7.5.

[0008] In some embodiments, the natural gel comprises one or more of agar, gelatin and xanthan gum.

[0009] In some embodiments, the natural pigment includes one or more of chlorophyll, anthocyanin, roselle pigment and cochineal.

[0010] In some embodiments, the colorant includes one or more of corn starch, titanium dioxide and pigment; the pigment includes one or more of CI 15850, CI 15985, CI 45410 and CI 77491.

[0011] In some embodiments, the colorant includes the corn starch, the titanium dioxide and the pigment, and the mass ratio of the corn starch, the titanium dioxide and the pigment is 1: (0.8-1.1): (0.8-1.1).

[0012] In some embodiments, the cannabidiol-containing gel also includes 0.01 to 1 parts by weight of a preservative; the preservative includes at least one of sodium benzoate, potassium sorbate and paraben.

[0013] A method for preparing the cannabidiol-containing gel comprises the following steps: Adding the natural gel into water, stirring evenly and heating to obtain a natural gel solution; Adding the cannabidiol, the Selaginella extract, the Sanguisorba officinalis extract, the natural pigment, the colorant, the polyvinyl pyrrolidone and the moisturizer into the natural gel solution, stirring evenly, to obtain a first intermediate product; Adding the pH regulator to the first intermediate product and stirring evenly to obtain a second intermediate product; The second intermediate product is cooled and shaped.

[0014] A use of the cannabidiol-containing gel in repairing facial laser trauma comprises the following steps: The cannabidiol-containing gel is applied to the surface of the facial laser wound so that the cannabidiol-containing gel is in direct contact with the wound.

[0015] Beneficial Effects The cannabidiol-containing gel of the present invention has excellent antibacterial, anti-inflammatory and moisturizing effects, and has a good repair effect on facial laser trauma. At the same time, the inventor found in the process of exploring facial laser trauma repair products that the mass ratio of cannabidiol, Selaginella extract and Sanguisorba officinalis extract is (2~4): (1~3): (1~3) The compound use can make the antibacterial and anti-inflammatory effects of the gel have a synergistic effect. At the same time, when cannabidiol, Selaginella extract, Sanguisorba officinalis extract are used in combination with natural pigments and polyvinyl pyrrolidone in natural gel, a stable color effect can be formed, and the color effect is mainly manifested as not easy to discolor and not easy to stain. When the gel is applied to the location of facial laser trauma, a beautiful color can be presented. And as time goes by, the color is not easy to fall off, and it is not easy to be stained on the surface of other objects. In this way, consumers can maintain the beauty of their faces while repairing facial laser trauma. Further, in the cannabidiol-containing gel of the present invention, a gel with rich color effects can be obtained by selecting natural pigments and colorants to meet the color aesthetic needs of consumers. Furthermore, the components of the gel containing cannabidiol are mainly derived from natural raw materials, and the gel is safe to use. In addition, the preparation method of the gel containing cannabidiol is simple and easy to implement, and is easy to promote. DETAILED DESCRIPTION

[0016] An embodiment of the present invention provides a gel containing cannabidiol, comprising the following components in parts by weight: 0.1-0.5 parts of cannabidiol, 0.1-0.5 parts of Selaginella extract, 0.1-0.5 parts of Sanguisorba officinalis extract, 20-40 parts of natural gel, 1-5 parts of natural pigment, 10-15 parts of colorant, 1-3 parts of polyvinyl pyrrolidone, 5-10 parts of moisturizer and 0.1-0.4 parts of pH adjuster; the mass ratio of cannabidiol, Selaginella extract and Sanguisorba officinalis extract is (2-4):(1-3):(1-3).

[0017] The cannabidiol-containing gel of the present invention has excellent antibacterial, anti-inflammatory and moisturizing effects, and has a good repair effect on facial laser trauma. At the same time, the inventor found in the process of exploring facial laser trauma repair products that the mass ratio of cannabidiol, Selaginella extract and Sanguisorba officinalis extract is (2~4): (1~3): (1~3) The compound use can make the antibacterial and anti-inflammatory effects of the gel have a synergistic effect. At the same time, when cannabidiol, Selaginella extract, Sanguisorba officinalis extract are used in combination with natural pigments and polyvinyl pyrrolidone in natural gel, a stable color effect can be formed, and the color effect is mainly manifested as not easy to discolor and not easy to stain. When the gel is applied to the location of facial laser trauma, a beautiful color can be presented. And as time goes by, the color is not easy to fall off, and it is not easy to be stained on the surface of other objects. In this way, consumers can maintain the beauty of their faces while repairing facial laser trauma. Further, in the cannabidiol-containing gel of the present invention, a gel with rich color effects can be obtained by selecting natural pigments and colorants to meet the color aesthetic needs of consumers. Furthermore, the components of the gel containing cannabidiol are mainly derived from natural raw materials, and the gel is safe to use. In addition, the preparation method of the gel containing cannabidiol is simple and easy to implement, and is easy to promote.

[0018] In some embodiments, the mass ratio of cannabidiol, Selaginella extract, and Sanguisorba officinalis extract is 1:1:1, 2:1:1, 2:1:2, 2:1:3, 3:1:1, 3:1:2, 3:1:3, 3:2:2, 4:1:1, 4:1:2, 4:1:3. Of course, the mass ratio of cannabidiol, Selaginella extract, and Sanguisorba officinalis extract can also be other suitable selections within the range of (2-4): (1-3): (1-3).

[0019] Optionally, when selecting the weight portion of cannabidiol, the weight portion of cannabidiol can be 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, etc. Of course, the weight portion of cannabidiol can also be other suitable selections within the range of 0.1 part-0.5 part.

[0020] Optionally, when selecting the weight portion of natural gel, the weight portion of natural gel can be 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, etc. Of course, the weight portion of natural gel can also be other suitable selections within the range of 20 parts to 40 parts.

[0021] Optionally, when selecting the weight portion of natural pigment, the weight portion of natural pigment can be 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.2 parts, 3.5 parts, 3.8 parts, 4 parts, 4.2 parts, 4.5 parts, 4.8 parts, 5 parts, etc. Of course, the weight portion of natural pigment can also make other suitable selections within the range of 1 part-5 parts.

[0022] Optionally, when selecting the weight of the colorant, the weight of the colorant can be 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, etc. Of course, the weight of the colorant can also be other suitable selections within the range of 10 parts to 15 parts.

[0023] Optionally, when selecting the weight portion of polyvinyl pyrrolidone, the weight portion of polyvinyl pyrrolidone can be 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, etc. Of course, the weight portion of polyvinyl pyrrolidone can also be other suitable selections within the range of 1 part to 3 parts.

[0024] Optionally, when selecting the weight of the moisturizing agent, the weight of the moisturizing agent can be 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, etc. Of course, the weight of the moisturizing agent can also be other suitable selections within the range of 5 parts to 10 parts.

[0025] Optionally, when selecting the weight portion of the pH adjuster, the weight portion of the pH adjuster can be 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, etc. Of course, the weight portion of the pH adjuster can also be other suitable selections within the range of 0.1 part to 0.4 part.

[0026] Further optionally, the cannabidiol-containing gel includes the following components in parts by weight: 0.03-0.08 parts of cannabidiol, 25-35 parts of natural gel, 1.5-3.5 parts of natural pigment, 11-13 parts of colorant, 1.5-2.5 parts of polyvinyl pyrrolidone, 7-9 parts of moisturizer and 0.15-0.3 parts of pH adjuster.

[0027] It will be appreciated that the cannabidiol-containing gel also includes water.

[0028] In some of the embodiments, the effective ingredients of the cannabidiol-containing gel include the following components in parts by weight: 0.01-0.1 parts of cannabidiol, 20-40 parts of natural gel, 1-5 parts of natural pigment, 10-15 parts of colorant, 1-3 parts of polyvinyl pyrrolidone, 5-10 parts of moisturizer and 0.1-0.4 parts of pH adjuster.

[0029] In some of the embodiments, the active ingredients of the cannabidiol-containing gel are composed of the following components in parts by weight: 0.01-0.1 parts of cannabidiol, 20-40 parts of natural gel, 1-5 parts of natural pigment, 10-15 parts of colorant, 1-3 parts of polyvinyl pyrrolidone, 5-10 parts of moisturizer and 0.1-0.4 parts of pH adjuster.

[0030] It can be understood that in the cannabidiol-containing gel, the weight parts of cannabidiol, Selaginella extract, Sanguisorba officinalis extract, natural gel, natural pigment, colorant, polyvinyl pyrrolidone, moisturizer and pH adjuster can be selected from the above weight parts respectively.

[0031] In some of the embodiments, the pH value of the gel containing cannabidiol is 6.5-7.5. This pH value range is close to neutral, which can make the gel containing cannabidiol more suitable for facial environment, reduce irritation to the face, and further improve the repair effect of the gel containing cannabidiol on facial laser trauma. Optionally, the pH value of the gel containing cannabidiol can be 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5, etc. Of course, the pH value of the gel containing cannabidiol can also be other suitable choices within the range of 6.5-7.5.

[0032] In some embodiments, the natural gel comprises one or more of agar, gelatin, and xanthan gum.

[0033] In some embodiments, the natural pigment includes one or more of chlorophyll, anthocyanin, roselle pigment and cochineal.

[0034] In some embodiments, the colorant includes one or more of corn starch, titanium dioxide and pigment; the pigment includes one or more of CI 15850, CI 15985, CI 45410 and CI 77491.

[0035] In some embodiments, the colorant includes corn starch, titanium dioxide and pigment, and the mass ratio of corn starch, titanium dioxide and pigment is 1: (0.8-1.1): (0.8-1.1). The adaptation of corn starch, titanium dioxide and pigment can make the displayed color more stable and further improve the color stability of the gel containing cannabidiol. Optionally, the mass ratio of corn starch, titanium dioxide and pigment is 1: 0.8: 0.8, 1: 0.8: 0.9, 1: 0.8: 1, 1: 0.8: 1.1, 1: 0.9: 0.8, 1: 0.9: 0.9, 1: 0.9: 1, 1: 0.9: 1.1, 1: 1: 0.8, 1: 1: 0.9, 1: 1: 1, 1: 1: 1.1, 1: 1.1: 0.8, 1: 1.1: 0.9, 1: 1.1: 1, 1: 1.1: 1.1, etc. Preferably, the mass ratio of corn starch, titanium dioxide and pigment is 1:1:1.

[0036] In some embodiments, the humectant includes one or more of glycerin, propylene glycol, sodium hyaluronate and sorbitol.

[0037] In some embodiments, the pH adjuster includes one or more of citric acid, sodium hydroxide, potassium hydroxide and triethanolamine.

[0038] In some embodiments, the gel containing cannabidiol also includes a preservative in an amount of 0.01-1 parts by weight; the preservative includes at least one of sodium benzoate, potassium sorbate and paraben. The use of a preservative can extend the service life of the gel containing cannabidiol. Optionally, the weight of the preservative can be 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts. Of course, the weight of the preservative can also be other suitable choices within the range of 0.01 parts to 1 parts.

[0039] Another embodiment of the present invention provides a method for preparing a gel containing cannabidiol, comprising the following steps: Adding natural gel into water, stirring evenly and heating to obtain a natural gel solution; Adding cannabidiol, Selaginella extract, Sanguisorba officinalis extract, natural pigment, colorant, polyvinyl pyrrolidone and moisturizer into the natural gel solution, stirring evenly to obtain a first intermediate product; Adding a pH regulator to the first intermediate product and stirring evenly to obtain a second intermediate product; The second intermediate product is cooled and shaped.

[0040] The preparation method of the cannabidiol-containing gel of the present invention is simple and easy, does not need to rely on complicated process flow and expensive production equipment, and is convenient for large-scale promotion.

[0041] Optionally, when the natural gel solution is obtained, the heating temperature is 70°C-95°C. At this time, the dissolution of the natural gel can be accelerated, so that a uniformly dispersed natural gel solution can be obtained. Further optionally, the heating temperature can be 70°C, 72°C, 75°C, 78°C, 80°C, 82°C, 85°C, 88°C, 90°C, 92°C, 95°C, etc. Of course, the heating temperature can also be other suitable selections within the range of 70°C-95°C.

[0042] Another embodiment of the present invention provides an application of a gel containing cannabidiol in repairing facial laser trauma, comprising the following steps: applying the gel containing cannabidiol to the surface of the facial laser trauma, so that the gel containing cannabidiol is in direct contact with the trauma. The gel containing cannabidiol in the present invention is in direct contact with the facial laser trauma, which can provide effective antibacterial, anti-inflammatory and moisturizing effects for the trauma, while making the wound site show rich and stable colors, meeting consumers' requirements for color aesthetics.

[0043] Example 1 The gel containing cannabidiol in this embodiment, its effective ingredients are composed of the following components in parts by weight: 0.1 parts of cannabidiol, 0.1 parts of Selaginella extract, 0.1 parts of Sanguisorba officinalis extract, 30 parts of agar, 3 parts of chlorophyll, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 2 parts of polyvinyl pyrrolidone, 8 parts of glycerol, and 0.2 parts of citric acid.

[0044] The preparation method of the gel containing cannabidiol in this embodiment is as follows: Add the natural gel into water, stir evenly and heat to 90°C to obtain a natural gel solution; Adding cannabidiol, Selaginella extract, Sanguisorba officinalis extract, natural pigment, colorant, polyvinyl pyrrolidone and moisturizer into the natural gel solution, stirring evenly to obtain a first intermediate product; Adding a pH regulator to the first intermediate product and stirring evenly to obtain a second intermediate product; The second intermediate product is cooled to room temperature to be fixed.

[0045] Example 2 The gel containing cannabidiol in this embodiment, its effective ingredients are composed of the following components in parts by weight: 0.2 parts of cannabidiol, 0.1 parts of Selaginella extract, 0.1 parts of Sanguisorba officinalis extract, 28 parts of agar, 2 parts of anthocyanins, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 2 parts of polyvinyl pyrrolidone, 8 parts of glycerol, and 0.2 parts of citric acid.

[0046] The preparation method of the gel containing cannabidiol in this embodiment is the same as the preparation method of the gel containing cannabidiol in Example 1.

[0047] Example 3 The gel containing cannabidiol in this embodiment has an effective ingredient composed of the following components in parts by weight: 0.3 parts of cannabidiol, 0.2 parts of Selaginella extract, 0.2 parts of Sanguisorba officinalis extract, 40 parts of gelatin, 4 parts of Roselle pigment, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 2 parts of polyvinyl pyrrolidone, 8 parts of glycerin, and 0.2 parts of citric acid.

[0048] The preparation method of the gel containing cannabidiol in this embodiment is the same as the preparation method of the gel containing cannabidiol in Example 1.

[0049] Example 4 The gel containing cannabidiol in this embodiment, its effective ingredients are composed of the following components in parts by weight: 0.5 parts of cannabidiol, 0.5 parts of Selaginella extract, 0.5 parts of Sanguisorba officinalis extract, 35 parts of xanthan gum, 4 parts of Roselle pigment, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 2.5 parts of polyvinyl pyrrolidone, 8 parts of glycerin, and 0.2 parts of citric acid.

[0050] The preparation method of the gel containing cannabidiol in this embodiment is the same as the preparation method of the gel containing cannabidiol in Example 1.

[0051] Comparative Example 1 The gel containing cannabidiol in this comparative example has an effective ingredient composed of the following components in parts by weight: 0.2 parts of cannabidiol, 28 parts of agar, 2 parts of anthocyanins, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 8 parts of glycerol, and 0.2 parts of citric acid.

[0052] The preparation method of the gel containing cannabidiol in this comparative example is similar to the preparation method of the gel containing cannabidiol in Example 1.

[0053] Comparative Example 2 The gel containing cannabidiol in this comparative example has an effective ingredient composed of the following components in parts by weight: 0.2 parts of cannabidiol, 0.1 parts of Selaginella extract, 28 parts of agar, 2 parts of anthocyanins, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 8 parts of glycerin, and 0.2 parts of citric acid.

[0054] The preparation method of the gel containing cannabidiol in this comparative example is similar to the preparation method of the gel containing cannabidiol in Example 1.

[0055] Comparative Example 3 The gel containing cannabidiol in this comparative example has an effective ingredient composed of the following components in parts by weight: 0.2 parts of cannabidiol, 0.1 parts of Sanguisorba officinalis extract, 28 parts of agar, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 8 parts of glycerin, and 0.2 parts of citric acid.

[0056] The preparation method of the gel containing cannabidiol in this comparative example is similar to the preparation method of the gel containing cannabidiol in Example 1.

[0057] Comparative Example 4 The gel in this comparative example has the following components in parts by weight as its active ingredients: 0.1 parts of Selaginella extract, 0.1 parts of Sanguisorba officinalis extract, 28 parts of agar, 4 parts of corn starch, 4 parts of titanium dioxide, 4 parts of CI 15850, 8 parts of glycerin, and 0.2 parts of citric acid.

[0058] The preparation method of the gel in this comparative example is similar to the preparation method containing cannabidiol in Example 1.

[0059] Test Example 1 The antibacterial properties and biocompatibility of the gels prepared in Examples 1-4 and Comparative Examples 1-4 (experimental groups) and the blank group (compared with Example 1, the blank group does not contain cannabidiol, Selaginella extract, and Sanguisorba officinalis extract) were tested, specifically including the following parts: Conventional antibacterial rate test: Two types of strains were selected for testing, namely Gram-positive bacteria (Staphylococcus) and Gram-negative bacteria (Escherichia coli). The agar diffusion method was used to test the antibacterial effect of the hydrogel on the strain. The hydrogels were smeared on the surface of the agar plate, and then different concentrations of bacterial solution were dropped on the center of the hydrogel surface. The plates were incubated at 37°C for 24 hours, and the inhibitory effects of different types of hydrogels on Gram-positive bacteria (Staphylococcus) and Gram-negative bacteria (Escherichia coli) were observed and recorded; the antibacterial rates of Gram-positive bacteria (Staphylococcus) and Gram-negative bacteria (Escherichia coli) corresponding to all test groups were calculated, and the average values ​​of the antibacterial rates of Gram-positive bacteria (Staphylococcus) and Gram-negative bacteria (Escherichia coli) were taken; the group without hydrogel application was used as the control group. The calculation formula for the antibacterial rate: (bacterial concentration of the blank group - bacterial concentration of the experimental group) / bacterial concentration of the blank group * 100%; 2. Biocompatibility test: refer to GB / T 16886.5-2003 for testing, where the biotoxicity score is: no cytotoxicity (0), slight cytotoxicity (1), moderate cytotoxicity (2), severe cytotoxicity (3); The test results are shown in Table 1; Table 1

[0060] It can be seen from Table 1 that when the technical solution of the present invention is adopted, the obtained gel has excellent conventional antibacterial rate and good biocompatibility. It can be seen from Examples 1-4 that the antibacterial rate of the gel obtained by compounding cannabidiol, Selaginella extract and Sanguisorba officinalis extract has a synergistic effect, and the conventional antibacterial rate of the gel obtained from Comparative Examples 1-4 shows a downward trend.

[0061] Test Example 2 The gels prepared in Test Examples 1-4 and Comparative Examples 1-4 and a blank group were subjected to a practical application effect simulation experiment, specifically comprising the following steps: Test method: 45 rabbits were randomly assigned to 9 groups, with an average of 5 rabbits in each group, and numbered in order corresponding to Examples 1-4, Comparative Examples 1-4 and the blank group. In the muscle on one side of the spine of each rabbit, parallel to the spine, 25mm-50mm away from the midline, the shaved area was about 25mm*25mm, and an artificial laser wound was simulated on the epidermis. The wounds of each rabbit were coated with the gels of Examples 1-4, Comparative Examples 1-4 and the blank group gel in turn, and the inflammatory response of the wounds was observed by naked eyes at different times. The observation period was 8 hours and 7 days; the evaluation of the wound condition after treatment is shown in Table 2.

[0062] Table 2

[0063] The wound healing status after treatment was statistically analyzed according to the evaluation form. The number of rabbits with wound inflammation and mild healing at 7 days in each group was counted respectively. The proportion of rabbits with mild wound healing at 7 days in each group was taken as the wound healing rate. The results are shown in Table 3.

[0064] Table 3

[0065] It can be seen from Table 3 that the gel obtained by adopting the technical solution of the present invention has an anti-inflammatory effect and can effectively promote the healing of wounds.

[0066] It can be seen from Examples 1-4 and Comparative Examples 1-4 that cannabidiol, Selaginella extract and Sanguisorba officinalis extract have obvious synergistic effects on wound healing, among which Example 2 has the best effect.

[0067] Test Example 3 800 patients who had undergone facial laser treatment were selected and randomly divided into 8 groups, with 100 patients in each group. Groups 1 to 8 respectively used the gels in Examples 1-4 and Comparative Examples 1-4 to repair facial laser wounds. The proportion of wound healing speed, the proportion of inflammatory reaction degree, and color retention time of each group of patients were observed. The results are shown in Table 4.

[0068] Table 4

[0069] It can be seen from the above table that the wound healing speed in the embodiment is faster than that in the comparative example, the degree of inflammatory reaction in the embodiment is lighter than that in the comparative example, and the color retention time in the embodiment is significantly longer than that in the comparative example.

[0070] Furthermore, it can be seen from Example 2 and Comparative Examples 1-4 that in the cannabidiol-containing gel, cannabidiol, Selaginella extract, Sanguisorba officinalis extract, natural pigments and polyvinyl pyrrolidone can obtain a more stable color retention effect when used in combination in the natural gel.

[0071] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

[0072] For those skilled in the art, according to the concept of the present invention, there may be changes in the specific implementation methods and application scopes. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A gel containing cannabidiol, characterized in that: The invention comprises the following components in parts by weight: 0.1-0.5 parts of cannabidiol, 0.1-0.5 parts of Selaginella extract, 0.1-0.5 parts of Sanguisorba officinalis extract, 20-40 parts of natural gel, 1-5 parts of natural pigment, 10-15 parts of colorant, 1-3 parts of polyvinyl pyrrolidone, 5-10 parts of moisturizer and 0.1-0.4 parts of pH adjuster; the mass ratio of the cannabidiol, the Selaginella extract and the Sanguisorba officinalis extract is (2-4):(1-3):(1-3).

2. The cannabidiol-containing gel according to claim 1, characterized in that The cannabidiol-containing gel includes the following components in parts by weight: 0.2-0.4 parts of cannabidiol, 0.1-0.3 parts of Selaginella extract, 0.1-0.3 parts of Sanguisorba officinalis extract, 25-35 parts of natural gel, 1.5-3.5 parts of natural pigment, 11-13 parts of colorant, 1.5-2.5 parts of polyvinyl pyrrolidone, 7-9 parts of moisturizer and 0.15-0.3 parts of pH adjuster.

3. The cannabidiol-containing gel according to claim 1, wherein The pH value of the cannabidiol-containing gel is 6.5-7.

5.

4. The cannabidiol-containing gel according to claim 1, wherein The natural gel comprises one or more of agar, gelatin and xanthan gum.

5. The cannabidiol-containing gel according to claim 1, wherein The natural pigment includes one or more of chlorophyll, anthocyanin, roselle pigment and cochineal.

6. The cannabidiol-containing gel according to claim 1, characterized in that The colorant includes one or more of corn starch, titanium dioxide and pigment; the pigment includes one or more of CI 15850, CI 15985, CI 45410 and CI77491.

7. The cannabidiol-containing gel according to claim 6, characterized in that The colorant includes the corn starch, the titanium dioxide and the pigment, and the mass ratio of the corn starch, the titanium dioxide and the pigment is 1: (0.8-1.1): (0.8-1.1).

8. The cannabidiol-containing gel according to any one of claims 1 to 7, characterized in that The cannabidiol-containing gel also includes 0.01 to 1 parts by weight of a preservative; the preservative includes at least one of sodium benzoate, potassium sorbate and paraben.

9. A method for preparing a gel containing cannabidiol as claimed in any one of claims 1 to 8, characterized in that: The steps include: Adding the natural gel into water, stirring evenly and heating to obtain a natural gel solution; Adding the cannabidiol, the Selaginella extract, the Sanguisorba officinalis extract, the natural pigment, the colorant, the polyvinyl pyrrolidone and the moisturizer into the natural gel solution, stirring evenly, to obtain a first intermediate product; Adding the pH regulator to the first intermediate product and stirring evenly to obtain a second intermediate product; The second intermediate product is cooled and shaped.

10. Use of a gel containing cannabidiol as claimed in any one of claims 1 to 8 in repairing facial laser trauma, characterized in that: The steps include: The cannabidiol-containing gel is applied to the surface of the facial laser wound so that the cannabidiol-containing gel is in direct contact with the wound.

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