VEGF-C or VEGF-D materials and methods for stimulation of neural stem cells

Abstract

The present invention relates to VEGF-C or VEGF-D materials and methods for promoting growth and differentiation of neural stem cells, neuronal and neuronal precursor cells, oligodendrocytes and oligodendrocyte precursor cells and materials and methods for administering said cells to inhibit neuropathology.

Description

VEGF-C or VEGF-D substances and methods for stimulating neural stem cells This application claims priority to US Patent Application 10 / 669,176 and US Provisional Patent Application 60 / 505,607, both filed September 23,2003. All priority applications are hereby incorporated by reference in their entirety. technical field The present invention provides substances and methods related to cellular and molecular biology and medicine, especially in the fields of vascularization and angiogenesis and the interaction of the vasculature with the nervous system. Background technique Interaction of neuropilin receptor protein with its ligands in the collapsin / semaphorin family of molecules promotes neuronal growth cone development and axon guidance--in neuronal tissue A process that regulates the path of an extending axon during development. Inappropriate retraction of neuronal growth cones will lead to undesired tissue hyperinnervation. Fafalins / semaphorins belong to a family of m...

AI Technical Summary

Problems solved by technology

However, the task of developing targeted therapies is complicated by the presence of multiple binding partners for neuropilin

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