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Integrated multiplex target analysis

a target analysis and multiplex technology, applied in the field of integrated multiplex system, can solve the problem of virtually no such commercial system

Inactive Publication Date: 2018-08-09
ROCHE MOLECULAR SYST INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a cartridge for conducting biological assays. The cartridge includes a liquid regent module with blisters that contain reagents and a sample inlet port. The reagents can be dispensed at a remote location when the blister is ruptured. The cartridge also includes an actuator system that causes the platen to move in response to the actuator plate, which allows the reaction to take place in a controlled environment. The technical effects of the patent include improved accuracy and reliability of biological assays, simplified operation, and reduced risk of contamination.

Problems solved by technology

One major challenge in the area of clinical and molecular diagnostics is the ability to have a “sample to answer” system that allows minimal sample handling and preparation, rapid assays as well as no requirement for highly trained laboratory personnel.
While many systems have been proposed, to date there are virtually no such commercial systems.

Method used

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Examples

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Embodiment Construction

I. Introduction

[0109]One major challenge in the area of clinical and molecular diagnostics is the ability to have a “sample to answer” system that allows minimal sample handling and preparation as well as no requirement for trained clinical lab personnel. While many systems have been proposed, to date there are virtually no such commercial systems. The present invention provides such an integrated, multiplex system. One of the significant benefits of the present system is that in many embodiments, the chip itself needs no moving parts, such as valves or pumps, due to the unique transport properties of the electrowetting system described below.

[0110]The present invention provides molecular diagnostic methods and compositions based on the detection of target analytes, including nucleic acids. The systems described herein are complete integrated “sample to answer” systems, in contrast with current commercial systems that require some off chip handling of the sample, generally including...

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Abstract

This invention provides biochip cartridges and instrument devices for the detection and / or analysis of target analytes from patient samples.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application of U.S. patent application Ser. No. 14 / 062,865, which was filed on Oct. 24, 2013, which claims the benefit of U.S. Provisional Patent Application Ser. No. 61 / 717,887, filed Oct. 24, 2012, and Ser. No. 61 / 798,091, filed Mar. 15, 2013, the respective disclosures of which are hereby incorporated by reference in their entirety.BACKGROUND OF THE INVENTION[0002]One major challenge in the area of clinical and molecular diagnostics is the ability to have a “sample to answer” system that allows minimal sample handling and preparation, rapid assays as well as no requirement for highly trained laboratory personnel. While many systems have been proposed, to date there are virtually no such commercial systems. The present invention provides such an integrated, multiplex system.BRIEF SUMMARY OF THE INVENTION[0003]The present invention provides biochip cartridges and instrument devices for the detection and...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/6825B01L3/00
CPCB01L3/502715B01L2400/0481C12Q1/6825B01L2400/0683B01L3/502738B01L3/502784B01L3/523B01L7/52B01L9/527B01L2200/025B01L2200/10B01L2200/16B01L2300/021B01L2300/0672B01L2300/0816B01L2300/0867B01L2300/1822B01L2300/1827B01L2400/0427
Inventor KAYYEM, JON FAIZSRINIVASAN, JAYASHANKARFORD, SEAN
Owner ROCHE MOLECULAR SYST INC
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