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Composition for Immunization Against Streptococcus Pneumoniae

a technology of streptococcus pneumoniae and composition, applied in the field of immunology, can solve the problems of large burden of deafness and other complications, excessive antibiotic consumption in children, and vaccines that are not very immunogenic in young children

Inactive Publication Date: 2019-03-07
SANOFI PASTEUR LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes methods to increase the production of specific immune cells that can fight disease. These methods have the advantage of promoting the immune system's ability to protect against disease.

Problems solved by technology

It is the most common infectious disease worldwide, leading to excessive antibiotic consumption in children in most countries and to a substantial burden of deafness and other complications in the developing countries (1-3).
This vaccine, however, is not very immunogenic in young children (Fedson, and Musher 2004, “Pneumococcal Polysaccharide Vaccine”, pp.
This vaccine is not recommended for the prevention of otitis media.
There are however limitations to conjugate vaccines.
For example, as such vaccines elicit serotype-specific protection, to protect against additional serotypes of Streptococcus pneumoniae including those that dominate in the developing world, additional serotype-specific polysaccharides must be included which increases the difficulty of manufacture (Di Fabio et al., Pediatr. Infect. Dis. J.
As for pneumococcal otitis media, the available conjugate vaccines do not work as well in protecting against the disease as they do to against invasive disease.

Method used

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  • Composition for Immunization Against Streptococcus Pneumoniae
  • Composition for Immunization Against Streptococcus Pneumoniae
  • Composition for Immunization Against Streptococcus Pneumoniae

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0082]To evaluate the otitis-prone condition in children, using pneumococcal protein antigens, Spn specific functional memory CD4+ Th-cell subsets in the peripheral blood of a cohort of non otitis-prone and otitis-prone children were enumerated. The B-cell IgG responses were also measured to the same antigens in the serum of the children of these cohorts.

[0083]Subjects were participants from a 5-year prospective longitudinal AOM study funded by the US NIH (26). Children having three episodes of AOM within 6 months or 4 episodes within one year were considered as otitis-prone while others who had fewer episodes were placed into the non otitis-prone group. Enrolled children were from a middle class, suburban socio-demographic population in Rochester N.Y. Healthy children at age of 6 months without prior AOM were enrolled and had serum, nasopharyngeal (NP) and oropharyngeal (OP) cultures obtained seven times, at the age 6, 9, 12, 15, 18, 24 and 30 months and both the cohorts had childr...

example 2

[0103]In this study, the development of serum IgG antibodies to PhtD, PhtE, LytB, PcpA and Ply among three groups of 6 to 36 month old children with AOM were compared: 1) an otitis prone group that included children who had three or more episodes of AOM in six months or four or more episodes in a 12 month period; 2) an AOM treatment failure (AOMTF) group that included children who failed to achieve bacterial eradication and / or resolution of symptoms after at least 48 hours of appropriate antibiotic therapy (70; 71) and children whose signs and symptoms of AOM returned within 14 days of completing an antibiotic treatment course; and, 3) a non-otitis prone group that included children who had only one or two episodes of AOM.

[0104]The samples collected and analyzed were obtained during the prospective study referenced in Example 1. Healthy children without prior AOM were enrolled at age 6 months and followed prospectively until 30 months of age. Serum, NP and oropharyngeal (OP) culture...

example 3

[0119]The circulating frequencies of Spn antigen-specific memory B-cells in sera samples obtained from a number of the otitis-prone and non-otitis prone children from the study referenced in Example 1 were assessed and compared. From the total study population of about 387 children, 22 children were studied here: 10 otitis-prone children were identified for study here (based on the availability of sufficient PBMC samples); and 12 non-otitis prone children, with 1 or 2 AOMs and of a similar age to the otitis-prone children were randomly selected to serve as controls. Clinical characteristics of the children are set out in Table 3.

[0120]Antigen-specific (PhtD, PhtE, LytB, PcpA, Ply) and total IgG secreting cells were quantified by an (in-house standardized) ELISPOT assay in which memory B-cells were stimulated in vitro to differentiate into antibody-secreting cells (ASC). Briefly, one million thawed PBMC were placed in each well of a 24-well plate containing 1 ml of complete media alo...

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Abstract

This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a therapeutically effective amount of a composition, at least once to the subject. The composition administered comprises at least one immunogenic polypeptide selected from the group consisting of Streptococcus pneumoniae PhtD, C PhtE, PcpA, LytB and detoxified pneumolysis

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. Ser. No. 13 / 990,853 filed on Jun. 25, 2014, now U.S. Pat. No. 9,944,680, that was filed under 35 U.S.C. § 371 from and claims priority to International Application No. PCT / US2011 / 063132, filed Dec. 2, 2011, which claims priority to U.S. Ser. No. 61 / 510,620 filed Jul. 22, 2011 and U.S. Ser. No. 61 / 419,635 filed Dec. 3, 2010, the contents of each being incorporated herein by reference in their entirety.FIELD OF THE DISCLOSURE[0002]This disclosure relates to the field of immunology and in particular, to methods of immunization against Streptococcus pneumoniae. BACKGROUND[0003]Otitis media is a common disease in children. The term “otitis media” encompasses a number of clinical disorders including myringitis, otitis media with effusion (OME), chronic suppurative otitis media and acute otitis media (AOM) (24). Acute otitis media (AOM) is a symptomatic illness associated with upper respiratory symptoms, pain, fever and o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K14/315A61K39/09
CPCC07K14/3156A61K39/092A61K2039/55A61P11/00A61P27/16A61P31/04A61P37/04A61K39/09
Inventor PICHICHERO, MICHAELOCHS-ONOLEMHEMHEN, MARTINA
Owner SANOFI PASTEUR LTD
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