Drug composition for treating vomiting

A technology of composition and chemotherapeutic drugs, applied in the directions of drug combination, digestive system, active ingredients of ketones, etc., can solve the problems of unclear mechanism, difficult quality control, unclear ingredients, etc., and achieves low price, remarkable drug effect, and small side effects. Effect

CN102423309BInactive Publication Date: 2013-01-16NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a drug composition for treating vomiting. The drug composition comprises the following components, wherein the components comprise, by weight, 1 part of succinic acid, 7 parts of malic acid, 10 parts of citric acid, 0.3 part of linoleic acid, 2.3 parts of 6-shogaol and 7 parts of 6-gingerol. With the drug composition of the present invention, various vomiting can be effectively treated.
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Description

technical field

[0001] The invention belongs to the field of medicines, in particular to a medicine composition for treating vomiting. Background technique

[0002] Vomiting is a common clinical phenomenon, especially for cancer chemotherapy patients. Many patients often have to give up chemotherapy or radiotherapy due to fear of postoperative vomiting, thus delaying their illness. Although there are many drugs for treating vomiting at present, the effect is not ideal. Although drugs such as ondansetron and granisetron have certain effects on chemotherapy vomiting, these drugs are expensive and have certain side effects. It also limits their use to a certain extent.

[0003] Vomiting belongs to the category of "qi inversion" in traditional Chinese medicine. The traditional medicine of the motherland believes that vomiting is caused by the loss of stomach and descending stomach qi. Traditional Chinese medicine has the irreplaceable advantages of synthetic drugs, cheap price...

Examples

Embodiment 1

[0020] A pharmaceutical composition for treating vomiting, which is prepared by uniformly mixing the following components by weight:

[0021] 1 part succinic acid;

[0022] 7 parts of hydroxysuccinic acid;

[0023] 10 parts of citric acid;

[0024] 0.3 parts of linoleic acid;

[0025] 2.3 parts of 6-shogaol;

[0026] 6-gingerol 7 parts.

experiment example 2

[0027] Experimental Example 2: Pharmacological effects of the composition of the present invention on emesis treatment.

[0028] 1. The effect on pica behavior in rats.

[0029] 1. Experimental materials

[0030] 1.1 sample, 1. the pharmaceutical composition that embodiment 1 makes, is mixed with the solution of certain concentration just before use. Preparation method: Take an appropriate amount of the pharmaceutical composition, weigh it accurately, add a certain amount of 0.5% CMC-Na, ultrasonicate for 10 minutes, and stir until fully suspended; ②Ondansetron injection (specification: 4mL·8mg -1 ; Batch number: 9090111EH; Shandong Qilu Pharmaceutical Co., Ltd.).

[0031] 1.2 Reagents, ① cisplatin (powder injection; specification: 10mg; batch number: 9110271DB; Shandong Qilu Pharmaceutical Co., Ltd.); ② kaolin (analytically pure, prepared with reference to the method of Takeda N, etc., mixing kaolin with 1% gum arabic to prepare Granules similar to animal feed); ③CMC-Na, a...