A preparation method of the active substance of Paecilomyces hematalis for reducing uric acid or treating hyperuricemia and the active substance prepared by the method and its application

Abstract

The invention relates to a preparation method of an active substance of Paecilomyces spp., the prepared active substance and its application. The method comprises the following steps: crushing the dried fermented Paecilomyces spp. Paecilomyces superfine powder; put the pulverized Paecilomyces mycelium in an extraction solvent, extract at 60-100°C for 1-3 hours, extract 1-3 times, filter the filtrate, and combine the filtrates; The filtrate is concentrated, and dried to obtain the Paecilomyces basalis extract, the obtained Paecilomyces basilicum superfine powder or the mixture (composite) of the Paecilomyces basilicum extract or the various extracts obtained It is the active substance of Paecilomyces bat moth. The preparation process of the active substance of Paecilomyces basilicum according to the present invention has high extraction rate, high active substance content and low cost; it has a significant effect of lowering uric acid, has a significant therapeutic effect and produces low side effects; and solves the problem of scarcity of natural Cordyceps resources .

Description

technical field

[0001] The invention relates to a preparation method of an active substance of Paecilomyces hematophila, the active substance prepared by the preparation method and the application of the active substance, which relate to the technical field of medicine or health care products. Background technique

[0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of hyperuricemia and gout in my country has been increasing year by year. Hyperuricemia is a disease in which blood uric acid exceeds the normal value due to purine metabolism disorder and / or uric acid excretion disorder, and it does not show any symptoms clinically. When the human body is in the condition of hyperuricemia for a long time, uric acid in the body is precipitated in the form of sodium salt in the joints, soft tissues, cartilage and kidneys, causing lesions in human organs and tissues, leading to gout and serious complications, su...

Examples

Embodiment 1

[0080] Take 100 g of Paecilomyces bacifera mycelium, pulverize it with a pulverizer, add it to an Erlenmeyer flask, add 1000 mL of distilled water to mix, reflux extraction at 100°C for 2 hours, and filter with a 400-mesh filter. Repeat the extraction once according to the above process, combine the obtained filtrates, concentrate under reduced pressure, and spray dry to obtain the water extract of Paecilomyces paecilomyces, that is, the active substance of Paecilomyces paecililis.

[0081] Premix the water extract of Paecilomyces hematoptera and the filler (the weight percentage of microcrystalline cellulose and isomalt is 1:2) according to the weight percentage of 1:1, and add lubricant and glidant in equal amounts to deliver Dilute and mix evenly, and go through the powder direct tableting process to obtain the Paecilomyces basilicum tablet.

Embodiment 2

[0083] Take 100 g of Paecilomyces bacifera mycelium, pulverize it with a pulverizer, put it into a round bottom flask, and add 2000 mL of 60% ethanol water to mix, reflux extraction at 80 ° C for 3 hours, and filter with a 200-mesh filter. Repeat the extraction once according to the above process, combine the obtained filtrates, distill and concentrate under reduced pressure, and freeze-dry to obtain the aqueous ethanol extract of Paecilomyces hematalis.

[0084] Take 100g of the mycelia of Paecilomyces paecilomyces, pulverize it with a pulverizer, perform mechanical shearing ultrafine pulverization for 15 minutes, and repeat the ultrafine pulverization once to obtain Paecilomyces paecilomyces with a particle size of 5-20 μm. Mildew ultrafine powder.

[0085] Mix the aqueous ethanol extract of Paecilomyces paecilomyces and the superfine powder of Paecilomyces paecilomyces at 14% and 86% by weight respectively to obtain the active substance of Paecilomyces paecilomyces, adding ...

Embodiment 3

[0087] Take 100 g of the mycelium of Paecilomyces basalis, pulverize it with a pulverizer, and then undergo mechanical shearing ultrafine grinding for 15 minutes, and repeat the ultrafine grinding 1 time to obtain Paecilomyces spp. with a particle size of 6-18 μm. The ultra-fine powder is the active substance of Paecilomyces phaecillum, which is packaged quantitatively to obtain the powder of Paecilomyces phaecillum.

technical field

[0001] The invention relates to a preparation method of an active substance of Paecilomyces hematophila, the active substance prepared by the preparation method and the application of the active substance, which relate to the technical field of medicine or health care products. Background technique

[0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of hyperuricemia and gout in my country has been increasing year by year. Hyperuricemia is a disease in which blood uric acid exceeds the normal value due to purine metabolism disorder and / or uric acid excretion disorder, and it does not show any symptoms clinically. When the human body is in the condition of hyperuricemia for a long time, uric acid in the body is precipitated in the form of sodium salt in the joints, soft tissues, cartilage and kidneys, causing lesions in human organs and tissues, leading to gout and serious complications, su...

Examples

Embodiment 1

[0080] Take 100 g of Paecilomyces bacifera mycelium, pulverize it with a pulverizer, add it to an Erlenmeyer flask, add 1000 mL of distilled water to mix, reflux extraction at 100°C for 2 hours, and filter with a 400-mesh filter. Repeat the extraction once according to the above process, combine the obtained filtrates, concentrate under reduced pressure, and spray dry to obtain the water extract of Paecilomyces paecilomyces, that is, the active substance of Paecilomyces paecililis.

[0081] Premix the water extract of Paecilomyces hematoptera and the filler (the weight percentage of microcrystalline cellulose and isomalt is 1:2) according to the weight percentage of 1:1, and add lubricant and glidant in equal amounts to deliver Dilute and mix evenly, and go through the powder direct tableting process to obtain the Paecilomyces basilicum tablet.

Embodiment 2

[0083] Take 100 g of Paecilomyces bacifera mycelium, pulverize it with a pulverizer, put it into a round bottom flask, and add 2000 mL of 60% ethanol water to mix, reflux extraction at 80 ° C for 3 hours, and filter with a 200-mesh filter. Repeat the extraction once according to the above process, combine the obtained filtrates, distill and concentrate under reduced pressure, and freeze-dry to obtain the aqueous ethanol extract of Paecilomyces hematalis.

[0084] Take 100g of the mycelia of Paecilomyces paecilomyces, pulverize it with a pulverizer, perform mechanical shearing ultrafine pulverization for 15 minutes, and repeat the ultrafine pulverization once to obtain Paecilomyces paecilomyces with a particle size of 5-20 μm. Mildew ultrafine powder.

[0085] Mix the aqueous ethanol extract of Paecilomyces paecilomyces and the superfine powder of Paecilomyces paecilomyces at 14% and 86% by weight respectively to obtain the active substance of Paecilomyces paecilomyces, adding ...

Embodiment 3

[0087] Take 100 g of the mycelium of Paecilomyces basalis, pulverize it with a pulverizer, and then undergo mechanical shearing ultrafine grinding for 15 minutes, and repeat the ultrafine grinding 1 time to obtain Paecilomyces spp. with a particle size of 6-18 μm. The ultra-fine powder is the active substance of Paecilomyces phaecillum, which is packaged quantitatively to obtain the powder of Paecilomyces phaecillum.

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