Weight-reducing medicine for diet-induced obesity as well as preparation method thereof

Abstract

The invention relates to a weight-reducing medicine for diet-induced obesity as well as a preparation method thereof. The active components of the weight-reducing medicine comprise resveratrol, chlorinated delphinium-3-O-glucoside, chlorinated cornflower-3-O-glucoside, catechin and pelargonidin-3-O-rutinoside; and the weight ratio of the resveratrol to the chlorinated delphinium-3-O-glucoside to the chlorinated cornflower-3-O-glucoside to the catechin to the pelargonidin-3-O-rutinoside is (1.6-2.4):(1.5-2.5):(4-6):(8-12):1. The main active components of the weight-reducing medicine provided bythe invention are derived from green kernel and black bean skin; in the use process of the medicine, food intake is not influenced, the diet-induced obesity can be effectively relieved, accumulationof internal fat is obviously reduced, good weight-reducing effect is achieved; and the weight-reducing medicine for diet-induced obesity has small dose and does not have side effect.

Description

technical field

[0001] The invention relates to the field of weight-loss drugs, in particular to a weight-loss drug for food-induced obesity and a preparation method thereof. Background technique

[0002] Overweight and obesity, a state of excess body fat accumulation, have been recognized as public health problems. Overweight and obesity not only lead to type 2 diabetes, coronary heart disease, high blood pressure, and osteoarthritis, but are also important factors that cause some chronic diseases and even mental diseases. There are many factors that cause obesity, such as genetic factors, intestinal flora imbalance, excessive intake of high-calorie foods, drugs (such as hormones), diseases, etc. Among them, high-calorie food intake, that is, food-induced obesity is the most common, causing many people to want to lose weight through dieting. Dieting can achieve the goal of weight loss, but it loses the fun of enjoying delicious food, and it is difficult to persist for a l...

Examples

Embodiment 1

[0036] A method for extracting the extract of green kernel and black bean skin with slimming effect, specifically comprising the following steps:

[0037] (1) Utilize 0.1% hydrochloric acid to acidify that the volume percentage is 80% ethanol to extract the green kernel black soybean skin (the ratio of solid to liquid is 1kg:15L), extract twice, combine the extracts, carry out decompression recovery ethanol, obtain concentrated solution A;

[0038] (2) The concentrated solution A is extracted and degreased with petroleum ether to obtain the concentrated solution B;

[0039] (3) Concentrate B is preliminarily purified by D101 macroporous resin, washed with water and eluted with 30% ethanol with a volume percentage of 4 times the column volume, concentrated under reduced pressure with 30% ethanol eluate, and dried at low temperature to obtain the preliminary purified extract object C;

[0040] (4) Weigh extract C (20g) and separate by column chromatography (7cm inner diameter)...

Embodiment 2

[0042] Capsule preparation:

[0043] With the green kernel and black soybean skin extract extracted in Example 1 as the active substance, the weight ratio for preparing the slimming capsule is as follows:

[0044]

[0045] Take by weighing 120g of Qingren black soybean skin extract of the present invention, 120g of starch, 156g of dextrin, 4g of magnesium stearate and mix according to the above weight ratio, moisten with 75% ethanol, granulate, dry, granulate, and fill Capsules, each capsule contains 0.4g, and each capsule contains 0.12g of the green kernel and black soybean skin extract of the present invention.

Embodiment 3

[0047] Respectively weigh 200 mg of resveratrol with a purity greater than 99%, 200 mg of delphinidin-3-O-glucoside chloride, 500 mg of cyanidin-3-O-glucoside chloride, 1000 mg of catechin, and geranium Prime-3-O-rutinoside 100 mg, mix the above raw materials evenly.

technical field

[0001] The invention relates to the field of weight-loss drugs, in particular to a weight-loss drug for food-induced obesity and a preparation method thereof. Background technique

[0002] Overweight and obesity, a state of excess body fat accumulation, have been recognized as public health problems. Overweight and obesity not only lead to type 2 diabetes, coronary heart disease, high blood pressure, and osteoarthritis, but are also important factors that cause some chronic diseases and even mental diseases. There are many factors that cause obesity, such as genetic factors, intestinal flora imbalance, excessive intake of high-calorie foods, drugs (such as hormones), diseases, etc. Among them, high-calorie food intake, that is, food-induced obesity is the most common, causing many people to want to lose weight through dieting. Dieting can achieve the goal of weight loss, but it loses the fun of enjoying delicious food, and it is difficult to persist for a l...

Examples

Embodiment 1

[0036] A method for extracting the extract of green kernel and black bean skin with slimming effect, specifically comprising the following steps:

[0037] (1) Utilize 0.1% hydrochloric acid to acidify that the volume percentage is 80% ethanol to extract the green kernel black soybean skin (the ratio of solid to liquid is 1kg:15L), extract twice, combine the extracts, carry out decompression recovery ethanol, obtain concentrated solution A;

[0038] (2) The concentrated solution A is extracted and degreased with petroleum ether to obtain the concentrated solution B;

[0039] (3) Concentrate B is preliminarily purified by D101 macroporous resin, washed with water and eluted with 30% ethanol with a volume percentage of 4 times the column volume, concentrated under reduced pressure with 30% ethanol eluate, and dried at low temperature to obtain the preliminary purified extract object C;

[0040] (4) Weigh extract C (20g) and separate by column chromatography (7cm inner diameter)...

Embodiment 2

[0042] Capsule preparation:

[0043] With the green kernel and black soybean skin extract extracted in Example 1 as the active substance, the weight ratio for preparing the slimming capsule is as follows:

[0044]

[0045] Take by weighing 120g of Qingren black soybean skin extract of the present invention, 120g of starch, 156g of dextrin, 4g of magnesium stearate and mix according to the above weight ratio, moisten with 75% ethanol, granulate, dry, granulate, and fill Capsules, each capsule contains 0.4g, and each capsule contains 0.12g of the green kernel and black soybean skin extract of the present invention.

Embodiment 3

[0047] Respectively weigh 200 mg of resveratrol with a purity greater than 99%, 200 mg of delphinidin-3-O-glucoside chloride, 500 mg of cyanidin-3-O-glucoside chloride, 1000 mg of catechin, and geranium Prime-3-O-rutinoside 100 mg, mix the above raw materials evenly.

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