Chromatographic column and ionization source interface for GC-IMS (Gas Chromatography-Insulated Mass Spectrometer) coupling technique

Abstract

The utility model provides a chromatographic column and ionization source interface for GC-IMS (gas chromatography-ion mobility spectrometry) coupling technique, which comprises a chromatographic column, an ion migration tube and a GC-IMS interface for connecting the chromatographic column and the ion migration tube, one end of the GC-IMS interface is a screw sleeved on the chromatographic column, and the other end of the GC-IMS interface is a nut fixed on the ion migration tube; the ion migration tube comprises an ionization source, a reaction area, an ion gate, a migration area and a migration tube air outlet, and the migration tube air outlet is located on the side face of the first electrode of the ion migration tube; the chromatographic column is horizontally sealed and fixed on the axis of the ion migration tube, is axially connected with the ion migration tube through a GC-IMS interface and penetrates through the ionization source, a gas outlet of the chromatographic column is positioned in the reaction region and is positioned between the ionization source and the ion gate, and eluate of the chromatographic column enters the reaction region under the driving of carrier gas for ionization analysis. And meanwhile, the eluate is quickly blown out of the ion migration tube under the action of one-way drift gas. According to the technical scheme of the utility model, the problems of GC-IMS flow matching and sample residue are solved, and the GC-IMS response time resolution is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of GC-IMS combination, and in particular to a GC-IMS combination technology chromatographic column and ionization source interface. Background Art

[0002] Ion mobility spectrometry (IMS) as a detector for gas chromatography (GC) was originally called plasma chromatography (PC) and was first reported in 1970 (MJ Cohen, FW Karasek J. Chromatogr. Sci., 8 (1970), p. 330). GC introduces the components of the mixture into IMS for detection and peak characterization. IMS acts as an ion interface between GC or mass spectrometer (MS) to provide three-dimensional analytical information. The gas chromatography-ion mobility spectrometry (GC-IMS) combined analysis method is a two-dimensional analytical method in which IMS performs sensitive and selective detection after chromatographic separation of compounds. IMS achieves secondary separation and highly sensitive detection of compounds by measuring the gas phase mobility of characteristic ions. The separation and detection process of GC-IMS can be divided into five separate steps: injection, compound separation, ion generation, ion separation, and ion detection. The advantage of GC-IMS coupling is that it greatly improves the separation ability of complex samples and eliminates the cross-sensitivity and charge competition problems between ions; IMS can further separate substances that cannot be separated due to the same or similar retention time, and realize secondary analysis. It is fast, sensitive and portable. After years of development, IMS has been recognized by the market as a gas chromatography selective detector. GC-IMS is widely used in the analysis of flavor substances in food science and technology, complex gas components in the environment, and biotechnology. The current representative manufacturer is GAS.

[0003] Both GC and IMS operate at near atmospheric pressure, so their coupling does not require a complex system, and the GC-IMS interface is simple and low-cost, and the IMS inlet can be directly connected to the outlet of the GC column. At present, domestic patents CN202121343049.9 and CN202110669990.8 have been applied for, which only disclose the snap-on connection of the GC column. Patent CN202222372181.3 uses discharge ionization and heats the interface, but does not involve the airflow inside the ionization source of the GC column; Patent CN201920282908.4 extends the VUV lamp irradiation time of the GC eluate, but the ion introduction process is tortuous and the ion utilization rate is extremely low. Although patents CN201310741366.X, CN201320878767.5, CN202111589494.8, and CN99804923.9 all involve GC-IMS interfaces, some use gas diversion (extremely poor sensitivity), some use solenoid valves (extremely poor time resolution), and some use belt enrichment thermal analysis (extremely poor time resolution and no flow rate matching). None of them involve how to match the GC eluate with the IMS ionization characteristics after entering the ionization source, sample dilution, and flow rate matching, which requires innovative design of the GC-IMS interface.

[0004] Like most detectors, IMS cannot respond immediately to changes in the concentration of the input sample (there is a reaction time). GC elution samples conform to pulse injection, and the sample concentration suddenly rises from zero to a certain finite value. After a period of time, the sample concentration suddenly drops to zero. Therefore, there is a problem of matching sample injection and response time when GC-IMS is used together. At the same time, the sample will accumulate or dilute in the IMS ionization region, and adsorb or desorb at the injection port or pipeline. There are problems such as matching the IMS float gas with the GC carrier gas flow, large interface dead volume and low sensitivity. Utility Model Content

[0005] According to the technical problems raised above, a GC-IMS coupling technology chromatographic column and ionization source interface is provided. The utility model solves the problems of dead volume and response time matching, and realizes rapid and highly sensitive response of samples.

[0006] The technical means adopted by the utility model are as follows:

[0007] A GC-IMS coupling technology chromatographic column and ionization source interface, a chromatographic column, an ion transfer tube, and a GC-IMS interface connecting the chromatographic column and the ion transfer tube, wherein:

[0008] The GC-IMS interface has a screw sleeved on the chromatographic column at one end and a nut fixed on the ion transfer tube at the other end;

[0009] The ion transfer tube comprises a transfer tube gas outlet, an ionization source, a reaction zone, an ion gate and a transfer zone. The transfer tube gas outlet is an array porous structure and is evenly distributed around the ionization source according to the shape of the ionization source.

[0010] The chromatographic column is horizontally sealed and fixed on the axis of the ion migration tube, is axially connected to the ion migration tube through a GC-IMS interface, and passes through an ionization source. The gas outlet of the chromatographic column is located in a reaction zone and between the ionization source and an ion gate. The eluate of the chromatographic column enters the reaction zone under the drive of a carrier gas for ionization analysis, and at the same time, the eluate is quickly blown out of the ion migration tube under the action of a unidirectional floating gas.

[0011] Furthermore, the interior of the screw is hollow and the head is a conical structure; the bottom of the nut is a conical structure.

[0012] Further, the ionization source comprises: a sheet ionization source or a cylindrical ionization source, wherein:

[0013] The sheet-like ionization source is a trumpet structure with its opening facing the reaction zone, and is arranged perpendicular to the axis of the ion transfer tube, and has multiple transfer tube gas outlets evenly distributed around it, so as to facilitate parallel purge of the floating gas in the ion transfer tube;

[0014] The cylindrical ionization source is a first cylindrical ionization source or a second cylindrical ionization source, wherein:

[0015] The first cylindrical ionization source is coaxially placed with the ion transfer tube, with one end of the inside being open and multiple transfer tube gas outlets evenly distributed around the other end to facilitate parallel purging of the floating gas in the ion transfer tube;

[0016] The second cylindrical ionization source is coaxially placed with the ion transfer tube, with one end open and the other end closed, and multiple transfer tube gas outlets are evenly distributed around the outside of the second cylindrical ionization source to facilitate parallel purge of floating gas in the ion transfer tube.

[0017] Furthermore, in the ion transfer tube, the drift gas is blown in from the transfer zone, passes through the ion gate (10), the reaction zone and the reaction zone, and the position arrangement of the gas outlet of the transfer tube is switched according to the structure of the ionization source.

[0018] Furthermore, the chromatographic column is a gas chromatography column, including a capillary column, an MCC column and a preparative column. The chromatographic column inserted into the ion migration tube is a non-metallic chromatographic column, and the insertion depth of the non-metallic chromatographic column is determined by the structure of the ion migration tube.

[0019] Furthermore, the ion gate includes a BN type ion gate, a TP type ion gate and a field switching ion gate.

[0020] Furthermore, the chromatographic column and the GC-IMS interface are both wrapped in a heating jacket to prevent sample condensation residue.

[0021] Compared with the prior art, the utility model has the following advantages:

[0022] 1. The GC-IMS coupling technology provided by the utility model has a chromatographic column and an ionization source interface, which directly connects the chromatographic column to the migration tube in a sealed manner, and the gas outlet of the chromatographic column is located in the ionization zone or reaction zone of the migration tube, so that the chromatographic eluted substances directly enter the migration tube, truly realizing zero interface dead volume when GC-IMS is coupled;

[0023] 2. The GC-IMS coupling technology provided by the utility model has an interface between the chromatographic column and the ionization source. The ionized substances of its ion mobility spectrum are mainly chemically ionized by the reaction reagent ions (RIP). Of course, there is also direct ionization, such as single photon ionization (SIP ionization) of a VUV lamp ionization source, which allows the chromatographic eluted substances to be directly injected into the RIP or ionization source, which is beneficial to improving the detection sensitivity of GC-IMS.

[0024] 3. The GC-IMS coupling technology provided by the utility model has a chromatographic column and an ionization source interface, and its ion migration spectrum adopts a unidirectional airflow to reduce the retention, eddy current and residual time of the sample in the migration tube, achieve the matching of the chromatographic elution time and the response time of the ion migration tube, and improve the GC-IMS response time resolution;

[0025] 4. The GC-IMS coupling technology provided by the utility model interfaces the chromatographic column with the ionization source. Under the purge of the floating gas, the eluted substances of the chromatographic column flow out of the chromatographic column to the blow-out migration tube, and pass through the reaction zone and the ionization zone in sequence. The samples are ionized into ions for a long enough time, and finally high-sensitivity detection is achieved;

[0026] 5. The GC-IMS coupling technology provided by the utility model interfaces the chromatographic column with the ionization source. Under the purge of the floating gas, the eluted material from the chromatographic column flows out of the chromatographic column to the blow-out migration tube, passes through the reaction zone and the ionization zone in sequence, and exists for a long enough time that the sample is ionized into ions, thereby achieving high-sensitivity detection.

[0027] 6. The GC-IMS coupling technology provided by the utility model provides a chromatographic column and an ionization source interface, which solves the GC-IMS flow matching problem and reduces sample dilution by adjusting the flow rate ratio of the floating gas and the carrier gas.

[0028] 7. The GC-IMS coupling technology provided by the utility model provides an interface between the chromatographic column and the ionization source. Before the chromatographic column enters the ion migration tube, the heating jacket is used for heating and heat preservation throughout the entire process, thereby reducing sample residues at the interface and increasing the elution speed.

[0029] Based on the above reasons, the utility model can be widely promoted in the fields of GC-IMS coupling and the like. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0031] Figure 1 A schematic diagram of the interface structure between a chromatographic column and a sheet-like ionization source provided in an embodiment of the utility model.

[0032] Figure 2 A schematic diagram of the structure of the interface between a chromatographic column and an ionization source, wherein the gas outlet is inside a cylindrical ionization source, provided in an embodiment of the utility model.

[0033] Figure 3 A schematic diagram of the structure of the interface between a chromatographic column and an ionization source, wherein the gas outlet is outside the cylindrical ionization source, provided in an embodiment of the utility model.

[0034] Figure 4 The embodiment of the utility model provides a GC-IMS spectrum of acetone using a chromatographic column and an ionization source interface structure with a gas outlet inside a cylindrical ionization source.

[0035] In the figure: 1, chromatographic column; 2, heating jacket; 3, screw; 4, nut; 5, ion migration tube; 6, ion migration tube outlet; 7, sheet ionization source; 7a, first cylindrical ionization source; 7b, second cylindrical ionization source; 8, reaction zone; 9, chromatographic column outlet; 10, ion gate; 11, migration zone. DETAILED DESCRIPTION

[0036] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0037] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is by no means a limitation on the utility model and its application or use. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0038] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the utility model. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0039] Unless otherwise specifically stated, the relative arrangement of the parts and steps described in these embodiments, the numerical expressions and numerical values ​​do not limit the scope of the utility model. At the same time, it should be clear that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to the actual proportional relationship. The technology, methods and equipment known to ordinary technicians in the relevant field may not be discussed in detail, but in appropriate cases, the technology, methods and equipment should be regarded as part of the authorization specification. In all examples shown and discussed here, any specific value should be interpreted as merely exemplary, rather than as a limitation. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar numbers and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

[0040] In the description of the present utility model, it needs to be understood that the directions or positional relationships indicated by directional words such as "front, back, up, down, left, right", "lateral, vertical, perpendicular, horizontal" and "top, bottom" are usually based on the directions or positional relationships shown in the drawings. They are only for the convenience of describing the present utility model and simplifying the description. Unless otherwise stated, these directional words do not indicate or imply that the device or element referred to must have a specific direction or be constructed and operated in a specific direction. Therefore, they cannot be understood as limiting the scope of protection of the present utility model: the directional words "inside and outside" refer to the inside and outside relative to the contours of each component itself.

[0041] For ease of description, spatially relative terms such as "above", "above", "on the upper surface of", "above", etc. may be used here to describe the spatial positional relationship between a device or feature and other devices or features as shown in the figure. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figure. For example, if the device in the accompanying drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below their position devices or structures". Thus, the exemplary term "above" can include both "above" and "below". The device can also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatially relative descriptions used here are interpreted accordingly.

[0042] In addition, it should be noted that the use of terms such as "first" and "second" to limit components is only for the convenience of distinguishing the corresponding components. If not otherwise stated, the above terms have no special meaning and therefore cannot be understood as limiting the scope of protection of the utility model.

[0043] like Figure 1-3 As shown, the utility model provides a GC-IMS coupling technology chromatographic column and ionization source interface, a chromatographic column 1, an ion migration tube 5 and a GC-IMS interface connecting the chromatographic column 1 and the ion migration tube 5, wherein:

[0044] The GC-IMS interface has a screw 3 sleeved on the chromatographic column 1 at one end and a nut 4 fixed on the ion transfer tube 5 at the other end;

[0045] The ion transfer tube 5 includes a transfer tube outlet 6, an ionization source, a reaction zone 8, an ion gate 10 and a transfer zone 11. The transfer tube outlet 6 is an array porous structure and is evenly distributed around the ionization source according to the shape of the ionization source.

[0046] The chromatographic column 1 is horizontally sealed and fixed on the axis of the ion migration tube 5, is axially connected to the ion migration tube 5 through the GC-IMS interface, and passes through the ionization source. The chromatographic column outlet 9 is located in the reaction zone 8 and between the ionization source and the ion gate 10. The eluate of the chromatographic column enters the reaction zone 8 under the drive of the carrier gas for ionization analysis. At the same time, the eluate is quickly blown out of the ion migration tube 5 under the action of the unidirectional floating gas, thereby improving the sensitivity and time resolution of the detected substance.

[0047] During specific implementation, as a preferred embodiment of the present utility model, the interior of the screw 3 is hollow and the head is a conical structure; the bottom of the nut 4 is a conical structure.

[0048] In the specific implementation, as a preferred embodiment of the utility model, the ionization source includes: a sheet ionization source 7 or a cylindrical ionization source, wherein:

[0049] The sheet-like ionization source 7 is a trumpet structure with its opening facing the reaction zone, and is arranged perpendicular to the axis of the ion transfer tube 5, and has multiple transfer tube gas outlets 6 evenly distributed around it, so as to facilitate parallel purge of the floating gas in the ion transfer tube 5;

[0050] The cylindrical ionization source is the first cylindrical ionization source 7a or the second cylindrical ionization source 7b, wherein:

[0051] The first cylindrical ionization source 7a is coaxially placed with the ion transfer tube 5, with one end of the inside being open and a plurality of transfer tube gas outlets 6 evenly distributed around the other end, so as to facilitate parallel purge of the floating gas in the ion transfer tube 5;

[0052] The second cylindrical ionization source 7 b is coaxially placed with the ion transfer tube 5 , with one end of the interior open and the other end closed, and multiple transfer tube gas outlets 6 are evenly distributed around the outside of the second cylindrical ionization source 7 b to facilitate parallel purge of the floating gas in the ion transfer tube 5 .

[0053] In this embodiment, the ionization source may be a radioactive ionization source, such as a tritium source, a nickel source or an americium source, or a vacuum ultraviolet lamp (VUV lamp), a corona discharge, or a laser pulse ionization source.

[0054] In specific implementation, as a preferred embodiment of the utility model, in the ion transfer tube 5, the drift gas is blown in from the migration zone 11, passes through the ion gate 10, the reaction zone and the reaction zone 8, and the position arrangement of the migration tube outlet 6 is switched according to the ionization source structure.

[0055] During specific implementation, as a preferred embodiment of the utility model, the chromatographic column 1 is a gas chromatography column, including a capillary column, an MCC column and a preparative column, and the chromatographic column inserted into the ion migration tube 5 is a non-metallic chromatographic column, and the insertion depth of the non-metallic chromatographic column is determined by the structure of the ion migration tube 5.

[0056] In specific implementation, as a preferred embodiment of the present invention, the ion gate 10 includes a BN-type ion gate, a TP-type ion gate and a field switching ion gate.

[0057] In specific implementation, as a preferred embodiment of the utility model, the chromatographic column 1 and the GC-IMS interface are both wrapped in a heating jacket 2 to prevent sample condensation residue.

[0058] Example 1

[0059] like Figure 1As shown, this embodiment provides a schematic diagram of the interface between a chromatographic column and a sheet ionization source, wherein the sheet ionization source 7 is placed perpendicular to the axis of the ion transfer tube 5, the sheet ionization source 7 is a trumpet structure with an opening toward the reaction zone, and multiple transfer tube outlets 6 are evenly distributed around it, which facilitates the parallel purge of the floating gas in the ion transfer tube 5. Through the GC-IMS interface, the chromatographic column 1 passes through the sheet ionization source 7 and is inserted into the reaction zone 8. The sample flowing out of the chromatographic column outlet 9 quickly flows out of the ion transfer tube 5 under the purge of the floating gas, effectively preventing the sample from remaining in the reaction zone 8 and the sheet ionization source 7, improving the time resolution of sample detection, and the sample is directly injected into the ion transfer tube 5 to achieve zero dead volume of the interface and improve the detection sensitivity. The flow ratio of the floating gas and the carrier gas is adjusted to achieve flow matching for GC-IMS coupling.

[0060] Example 2

[0061] like Figure 2 As shown, this embodiment provides a schematic diagram of the interface between a chromatographic column and an ionization source with an outlet inside a cylindrical ionization source. The first cylindrical ionization source 7a is coaxially placed with the ion migration tube 5, one end of which is open inside the ionization source 7b, and multiple migration tube outlets 6 are evenly distributed around the one end, so as to facilitate the parallel purge of the floating gas in the ion migration tube 5. Through the GC-IMS interface, the chromatographic column 1 passes through the first cylindrical ionization source 7a and is inserted into the reaction zone 8. The sample flowing out of the chromatographic column outlet 9 passes through the reaction zone 8 and the first cylindrical ionization source 7a under the purge of floating gas, and the double ionization mode is used to improve the detection sensitivity; due to the use of a unidirectional airflow mode, it can effectively prevent the sample from remaining in the reaction zone 8 and the first cylindrical ionization source 7a, and improve the time resolution of sample detection. This structure also achieves zero interface dead volume.

[0062] Example 3

[0063] like Figure 3 As shown, this embodiment provides a schematic diagram of the interface between a chromatographic column and an ionization source with an outlet outside the cylindrical ionization source, the second cylindrical ionization source 7b is coaxially placed with the ion migration tube 5, one end of the second cylindrical ionization source 7b is open and the other end is closed, and multiple migration tube outlets 6c are evenly distributed around the outside of the second cylindrical ionization source 7b, which facilitates the parallel purge of the floating gas in the migration tube 5. Through the GC-IMS interface, the chromatographic column 1 passes through the second cylindrical ionization source 7b and is inserted into the reaction zone 8. The sample flowing out of the chromatographic column outlet 9 passes through the reaction zone 8 under the purge of the floating gas, and the material detection is mainly achieved through RIP chemical ionization; due to the use of a unidirectional airflow mode, it can effectively prevent the sample from remaining in the reaction zone 8 and the second cylindrical ionization source 7b, thereby improving the time resolution of sample detection. This structure also achieves zero interface dead volume.

[0064] Example 4

[0065] like Figure 4As shown, this embodiment provides a GC-IMS spectrogram of acetone using a chromatographic column with an air outlet inside a cylindrical ionization source and an ionization source interface structure, and the detection conditions are: the ionization source is a nickel source, the air drift gas flow rate is 400ml / min, the air carrier gas flow rate is 20ml / min, the GC and interface heating jacket temperature is 60 degrees, the migration tube temperature is 100 degrees, and the acetone concentration is 85ppb. It can be seen from the 2D thermal map that the chromatographic column and the ionization source interface structure can quickly elute acetone from the migration tube without tailing, achieving high sensitivity and time resolution. The problems of matching the elution of GC samples with the response time of ion migration spectrometry, matching the flow rate of IMS drift gas with the GC carrier gas, large interface dead volume and low sensitivity are solved.

[0066] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, ordinary technicians in this field should understand that they can still modify the technical solutions recorded in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not make the essence of the corresponding technical solution deviate from the scope of the technical solution of the embodiments of the utility model.

Claims

1. A GC-IMS combined technology chromatographic column and ionization source interface, characterized in that: include: A chromatographic column (1), an ion migration tube (5), and a GC-IMS interface connecting the chromatographic column (1) and the ion migration tube (5), wherein: The GC-IMS interface has a screw (3) sleeved on the chromatographic column (1) at one end and a nut (4) fixed on the ion migration tube (5) at the other end; The ion transfer tube (5) comprises a transfer tube gas outlet (6), an ionization source, a reaction zone (8), an ion gate (10) and a transfer zone (11); the transfer tube gas outlet (6) is an array porous structure and is evenly distributed around the ionization source according to the shape of the ionization source; The chromatographic column (1) is horizontally sealed and fixed on the axis of the ion transfer tube (5), axially connected to the ion transfer tube (5) via a GC-IMS interface, and passes through an ionization source. The chromatographic column gas outlet (9) is located in the reaction zone (8) and between the ionization source and the ion gate (10). The eluate of the chromatographic column enters the reaction zone (8) driven by the carrier gas to perform ionization analysis. At the same time, the eluate is quickly blown out of the ion transfer tube (5) under the action of the unidirectional floating gas.

2. The GC-IMS coupling technology chromatographic column and ionization source interface according to claim 1, characterized in that: The interior of the screw (3) is hollow and the head is a conical structure; the bottom of the nut (4) is a conical structure.

3. The GC-IMS coupling technology chromatographic column and ionization source interface according to claim 1, characterized in that: The ionization source comprises: a sheet ionization source (7) or a cylindrical ionization source, wherein: The sheet-like ionization source (7) is a trumpet structure with its opening facing the reaction zone, and is arranged perpendicular to the axis of the ion transfer tube (5), and has multiple transfer tube gas outlets (6) evenly distributed around it, so as to facilitate parallel purging of the floating gas in the ion transfer tube (5); The cylindrical ionization source is a first cylindrical ionization source (7a) or a second cylindrical ionization source (7b), wherein: A first cylindrical ionization source (7a) is coaxially placed with the ion transfer tube (5), one end of which is open and the other end is evenly distributed with a plurality of transfer tube gas outlets (6) around it, so as to facilitate parallel purging of floating gas in the ion transfer tube (5); The second cylindrical ionization source (7b) is coaxially placed with the ion transfer tube (5), with one end of the interior being open and the other end being closed, and a plurality of transfer tube gas outlets (6) are evenly distributed around the exterior of the second cylindrical ionization source (7b) to facilitate parallel purging of floating gas in the ion transfer tube (5).

4. The GC-IMS coupling technology chromatographic column and ionization source interface according to claim 2, characterized in that: In the ion transfer tube (5), drift gas is blown in from the transfer zone (11), passes through the ion gate (10), the reaction zone and the reaction zone (8), and the position arrangement of the transfer tube gas outlet (6) is switched according to the ionization source structure.

5. The GC-IMS coupling technology chromatographic column and ionization source interface according to claim 1, characterized in that: The chromatographic column (1) is a gas chromatographic column, including a capillary column, an MCC column and a preparative column. The portion of the chromatographic column inserted into the ion migration tube (5) is a non-metallic chromatographic column, and the insertion depth of the non-metallic chromatographic column is determined by the structure of the ion migration tube (5).

6. The GC-IMS coupling technology chromatographic column and ionization source interface according to claim 1, characterized in that: The ion gate (10) comprises a BN type ion gate, a TP type ion gate and a field switching ion gate.

7. The GC-IMS coupling technology chromatographic column and ionization source interface according to claim 1, characterized in that: The chromatographic column (1) and the GC-IMS interface are both wrapped in a heating jacket (2) to prevent sample condensation residue.

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