2 results about "Spermatozoa Capacitation" patented technology

The application discloses a sperm protein marker LYPD4 closely related to human sperm hyperactivation movement and an application thereof, and belongs to the technical field of biology.The application first proves that the LYPD4 protein is closely related to human sperm hyperactivation movement, and the relative content of the LYPD4 protein is significantly positively correlated with the human sperm hyperactivation rate; the LYPD4 antibody can significantly inhibit the total activity, forward movement, hyperactivation movement, penetration mucus capacity and sperm capacitation level of human sperm.The application provides a new application of the LYPD4 as a sperm function evaluation biomarker, and can be used for preparing a human sperm hyperactivation capacity detection kit, screening high-quality sperm for assisted reproduction, male infertility diagnosis and therapeutic drugs.The application fills a research blank of specific molecular markers of sperm hyperactivation movement, provides a new target and a new method for male reproductive health diagnosis and treatment and assisted reproduction technology, and has important scientific research value and clinical application prospect.

The present application relates to the field of animal reproduction technology, and in particular to a sperm protection agent for improving sperm preservation quality and embryo development potential and application thereof, wherein the effective components of the sperm protection agent are selected from any one or several of acetyl carnitine, glycerophosphocholine, tauroursodeoxycholic acid, glutamic acid, sunflower acylcarnitine, pyridoxal phosphate and glyco ursodeoxycholic acid. Based on the regulation of the OR4C13-G13 / Golf signal axis related to sperm capacitation of the effective components, sperm viability can be maintained during preservation, premature capacitation can be inhibited, and the fertilization rate and embryo development potential can be improved. The present application is suitable for the normal temperature preservation of pig semen and can be extended to other mammalian or human assisted reproduction fields.