95 results about "Sulfonylurea compounds" patented technology

The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.

The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the NCCa-ATP channel, including SUR1 antagonists, are useful in the prevention, diminution, and treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury. Agonists of the NCCa-ATP channel may be are useful in the treatment neural tissue where damage or destruction of the tissue, such as a gliotic capsule, is desired.

An agent for treating diabetes with sulfonylurea secondary failure which comprises a dipeptidyl peptidase IV inhibitor. The agent of the present invention is an agent for treating diabetes with sulfonylurea secondary failure showing excellent insulin-secreting and hypoglycemic effects on even diabetic patients on whom a sulfonylurea compound or a fast-acting insulin secretagogue has no insulin-secreting effect and therefore no sufficient hypoglycemic effect.

The invention relates to a compounded herbicide composition for rice fields, which contains the following two effective components: component (A): pyribenzoxim; component (B): a herbicide which is one of the following compounds: triazines compounds, heterocyclic compounds, phenoxy compounds, amide compounds, diphoenyl ether compounds, sulfonylurea compounds, phenoxyalkanoic acid compounds, botanical compounds, organic phosphorus compounds, urea compounds, dinitroaniline compounds, benzamide compounds and carbamate compounds; and wherein, the weight ratio of the component (A) to the component (B) is 1-50: 1-50.

A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.

The invention relates to a preparation method and application of a sulfonylurea compound and a composition containing the same component as FXR and / or TGR5 agonist, the FXR and / or TGR5 agonist is a compound shown as a formula (I), or a pharmaceutically acceptable salt, a solvate, a prodrug, an isomer and a stable isotope derivative thereof. The compounds can be used for treatment of FXR and / or TGR5 mediated diseases including primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity and other field.

The present invention features a novel therapy for treating diabetes, hypertension, migraine, epilepsy, sleep apnea, depression, impulse control disorders or alcohol addiction which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) in combination with an anticonvulsant sulfamate compound (e.g., topiramate) or an anticonvulsive sulfonylurea compound (e.g. zonisamide).

The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.

A herbicidal composition comprising a herbicidal sulfonylurea compound or its salt, and an alkoxylated glyceride. A method for controlling undesired plants or inhibiting their growth, which comprises applying a herbicidally effective amount of the herbicidal composition to the undesired plants or to a place where they grow. A method for enhancing the herbicidal effect of a herbicidal sulfonylurea compound or its salt by means of an alkoxylated glyceride.

The present invention relates to the use of sulfonylurea compounds to alter physical and / or growth characteristics of poppy plants.

The invention provides a herbicide composition. The herbicide composition comprises a fluroxypyr derivative, mesotrione and a sulfonylurea compound, wherein the weight part ratio of the fluroxypyr derivative to the mesotrione to the sulfonylurea compound is 0.1-5:0.1-10:0.1-10. The composition can be prepared into emulsifiable concentrate, liquor, aqua, dense emulsion, microemulsion, wettable powder, water suspension, oil suspension, water dispersible granules or soluble powder (granules). The herbicide composition of the invention can be used for preventing and controlling annual and perennial grasses and broadleaves.

2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.

To provide a herbicidal composition having a wide herbicidal spectrum, being highly active and having a long lasting effect. A herbicidal composition comprising (α) a compound of the formula (I) or its salt: wherein R is a hydrogen atom or —COCH2OCH3 and (β): at least one compound selected from the group consisting of the following compounds, as active ingredients: at least one sulfonylurea compound selected from (B1.1) bensulfuron-methyl, (B1.2) azimsulfuron, etc.; (B2.1) pyriminobac-methyl; an acetamide compound such as (B3.1) pretilachlor, etc.; at least one benzoyl compound selected from (B4.1) benzobicyclon, (B4.2) mesotrione, etc.; (B5.1) simetryn; and so on.

The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the NCCa-ATP channel, including SUR1 antagonists, are useful in the prevention, diminution, and treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury. Agonists of the NCCa-ATP channel may be are useful in the treatment neural tissue where damage or destruction of the tissue, such as a gliotic capsule, is desired.

The invention relates to a sulfonylurea compound synthesizing method and grass-clearing active. The general formula of the compound is (I), in which R1 is 1-6 alkyl, 1-6 alkoxy, 1-6 carbonyl, halogen or nitro group; R2 is 1-6 alkyl, 1-6 alkoxy, 1-4 alkyl sulfide, 1-4 alkylamino radical, halogen or nitro group; R3 is 1-6 alkyl, 1-6 alkoxy, 1-6 alkyl substitution, 1-6 acylaminosulfonamides, 1-6 alkylamine, aryl, aryl substituent, halogen or nitro group. The invention possesses elite grass-clearing active and selective to crop, and it especially can be used as weed killer to eliminate broadleaf weed in corn field.

The invention relates to the field of pesticide preparations, and discloses a rice field weeding composite and a preparation thereof. The weeding composite is prepared from sulphonamide compound pyrimisulfan and a sulfonylurea compound with a ratio weight of 1:10-20:1. According to the rice field weeding composite and the preparation thereof, the sulphonamide compound pyrimisulfan and the sulfonylurea compound are compounded to serve as an active ingredient; the sulphonamide compound pyrimisulfan and the sulfonylurea compound, which complement each other in advantages and synergistically act, can be used for slowing the generation of herbicide resistance of weeds and meanwhile has a synergistic effect on rice field weeding; the use amount and the number of use times of the herbicide are reduced greatly, so that the composite and the preparation thereof have the advantages of safety, high efficiency, environment friendliness and the like and can be widely used for preventing and controlling rice field weeds.

The present invention belongs to the field of genje engineering technology. It particular, it relates to a promoter segment capable of separating and utilizing nucleic acid. Said promoter is originated from some genes which are sensitive to sulfonylurea compounds (such as chlor-sulfuron and ethametsulfuron) and related compounds in the plants of rice, etc. The nucleic acid sequence of the coded desired target product gene and one above-mentioned promotor segment are fused to obtain recombinant DNA, then this recombinant DNA is used to transform plant, and a new transgenic plant can be obtained. The expression of target gene being in said recombinant DNA in the new plant is controlled by proper chemical inducer.

The invention discloses a herbicide, which is composed of glyphosate or glyphosate salt and sulfonylurea compounds; the weight ratio of glyphosate or glyphosate salt: sulfonylurea compounds = 10-100:1. the invention further discloses a powder form herbicide prepared from the above herbicide, which comprises the following components with contents of: 25-85% of herbicide and 3-12% of ammonium sulfate, 7-18% of auxiliary agent, 0-42% of filling material and 2-60% of sodium sulphate. The herbicide is used for controlling water area weed.

A herbicidal composition comprising a herbicidal sulfonylurea compound or its salt, and an alkoxylated glyceride. A method for controlling undesired plants or inhibiting their growth, which comprises applying a herbicidally effective amount of the herbicidal composition to the undesired plants or to a place where they grow. A method for enhancing the herbicidal effect of a herbicidal sulfonylurea compound or its salt by means of an alkoxylated glyceride.

The invention relates to a weed killing composition containing pyraflufen ethyl and sulfonylurea compounds. The composition is mainly characterized in that the pesticide composition contains 1-60% of effective ingredient A, 1-80% of effective ingredient B and the balance of auxiliaries. The effective ingredient A is pyraflufen ethyl, and the effective ingredient B is selected from tribenuron-methyl or thifensulfuron methyl. The composition can be prepared into wettable powder, water dispersible granules, microemulsions, emulsions in water, oil suspensions and suspending emulsions. The pesticide composition provided by the invention can be used for controlling weeds in wheat fields and corn fields.

This invention relates to a novel sulfonylurea compound or its pharmaceutical salt, their preparation method and pharmaceutical application. The novel sulfonylurea compound or its pharmaceutical salt can be used in drugs for preventing and treating diabetes or other diseases. The compound can be manufactured into oral liquids, injections and external use preparations.

The invention provides a herbicide composition. The herbicide composition comprises a fluroxypyr derivative, mesotrione and a sulfonylurea compound, wherein the weight part ratio of the fluroxypyr derivative to the mesotrione to the sulfonylurea compound is 0.1-5:0.1-10:0.1-10. The composition can be prepared into emulsifiable concentrate, liquor, aqua, dense emulsion, microemulsion, wettable powder, water suspension, oil suspension, water dispersible granules or soluble powder (granules). The herbicide composition of the invention can be used for preventing and controlling annual and perennial grasses and broadleaves.

The invention relates to a preparation method of a compound represented by a formula (I). The compound is prepared by reacting a compound represented by a formula (II) with a compound represented by a formula (III) in a solvent under the catalysis of a palladium catalyst in carbon monoxide atmosphere, wherein X is O or N; N is 0 or 1; when X is O, n is equal to 0; when X is N, n is equal to 1; R1 is selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R2 is selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R3 is selected from H, R2 forms a ring, or R2 and R2 are linked to form a ring; R4 is N3 or a halogen atom; when R4 is the halogen atom, a system further contains sodium azide. The preparation method has the beneficial effects that the reaction does not require strict anhydrous and anaerobic conditions and high-pressure carbon monoxide atmosphere, the operation is convenient and simple, and the reaction has very good tolerance and universality to functional groups; meanwhile, the use level of a catalyst is extremely low, the reaction cost is very low, and the method can be widely applied to the preparation of sulfonylurea compounds.

The object is to prepare an aqueous suspension-type herbicide composition which can avoid the decomposition of a herbicidal sulfonylurea compound in water and can also retain a stable suspension state, without the need of using any complicated step. An aqueous suspension-type herbicide composition comprising: (1) at least one herbicidal sulfonylurea compound selected from the group consisting of 1-[3-[(4,6-dimethoxypyrimidin- 2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate, N-[(4,6-dimethoxypyrimidin-2- yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3- pyridinesulfonamide and salts thereof; (2) an inorganic salt; (3) at least one sulfonate salt selected from the group consisting of an arylsulfonate, an alkylarylsulfonate and formalin condensates thereof; and (4) water.

The invention discloses a 6-methylcoumarin-7-sulfonylurea compound with the following structural formula and a synthetic method of the compound. Proofed by an initial pharmacological test, the hypoglycemic activity of the 6-methylcoumarin-7-sulfonylurea compound is similar to 6-bit substitution, and the 6-methylcoumarin-7-sulfonylurea compound can be used as a substitution product of a coumarin-6-sulfonylurea compound. The synthetic method of the 6-methylcoumarin-7-sulfonylurea compound is easy and has an industrialization prospect.

The invention provides construction and application of an endoplasmic reticulum targeted nano drug delivery system. By modifying sulfamide or sulfonylurea compounds with endoplasmic reticulum tendencyinto endoplasmic reticulum targeting nano-compounds constructed in a nano-carrier, the constructed novel endoplasmic reticulum targeting liposome can load water-soluble and fat-soluble drugs and quickly transfer the drugs to the endoplasmic reticulum part, so that accumulation of the drugs at the action part of the liposome is improved, and the bioavailability of the drugs is improved. The medicine treatment effect is enhanced, and the toxic and side effect is weakened; the delivery of nucleic acid drugs needing lysosome escape can be remarkably improved, and a new strategy is provided for exerting the curative effect of the drugs. The nano-carrier disclosed by the invention is not only limited to lipidosome, but also can be solid lipid nanoparticles, nano-emulsion, polymer micelles and the like. The endoplasmic reticulum targeted modification nano-carrier provided by the invention is novel in scheme and simple in preparation method, and has good industrial production and applicationprospects.

The present invention provides sulfonylurea compounds of formula (VIII) and pharmaceutically acceptable derivatives thereof and a process for making thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and / or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention also provides a method for inhibition platelet ADP receptor and preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (VIII) or a pharmaceutically acceptable salt or forms thereof.

There is provided a novel herbicide. A pyrazole sulfonylurea compound of formula (1): wherein R1 is C1-3alkyl, etc., R2 is hydrogen atom, C1-3alkyl, C1-3haloalkyl, etc., R3, R4, R5 and R6 independently of one another are hydrogen atom, C1-3alkyl, etc., with a proviso that at least one of R3, R4, R5 and R6 is C1-3alkyl or C1-3haloalkyl, X and Y independently of each other are C1-3alkyl, etc., Z is nitrogen atom or methyne, and a salt thereof that is acceptable as an agrochemical; an agrochemical containing at least one of the compound and the salt thereof that is acceptable as an agrochemical as an active component, and a herbicide containing at least one of the compound and the salt thereof that is acceptable as an agrochemical as an active component.

Herbicidal composition comprises a sulfonylurea herbicide (I) and a safener (II), where (I) is metsulfuron, thifensulfuron, tribenuron, chlorsulfuron or a salt or ester thereof and (II) is mefenpyr, isoxadifen, cloquintocet, fenchlorazol or its salt or ester. - An INDEPENDENT CLAIM is also included for controlling harmful plants in crops by applying the components of a composition as above together or separately to the harmful plants, the crop plants, plant seeds or growing surface. - ACTIVITY - Herbicide. - MECHANISM OF ACTION - None given.