7 results about "Sulfonylurea compounds" patented technology

The invention relates to a series of sulfonylurea compounds with high herbicidal activity and safety to crops as well as a preparation method and application thereof. The sulfonylurea compounds with 5-site amido substituted benzene rings as shown in a general formula I are disclosed firstly; or a sodium salt derivative of the compound as shown in the general formula I, and the structure is as shown in a general formula II; the sulfonylurea compounds or derivatives shown in the general formula I or the general formula II can be used for preparing agricultural chemical herbicides and used for preventing and controlling weeds. When the sulfonylurea compound with the novel structure is used as a herbicide, a relatively good weeding inhibition rate can be ensured, and the safety of food crops can be ensured.

The present application relates to sulfonylurea compounds, in particular to compounds having both sulfonylurea and 2-(furan-2-yl)propan-2-ol, and to related salts, solvates, prodrugs, and compositions. The present application also relates to the use of the compounds as medicaments for the treatment and prevention of medical conditions and diseases by NLRP3 inhibition. The present application also relates to the use of the compounds as medicaments for the treatment and prevention of medical conditions and diseases by NLRP3 inhibition. The sulfonylurea compounds of the present application have strong NLRP3 inflammasome inhibitory activity.

The present application relates to a kind of sulfonylurea compounds as shown in formula I, preparation method and its application.The compound of the present application has soluble epoxide hydrolase (sEH) inhibitory activity, can increase the level of epoxyeicosatrienoic acid (EETs), and then reduce inflammatory response, can be used for the prevention and treatment of heart failure.The preparation method of the present application has the technical advantages of simple steps, high yield and easily available raw materials.

The invention relates to a sulfonylurea compound and application of the sulfonylurea compound in preparation of herbicide for preventing and controlling resistant weeds, in particular to application of the sulfonylurea compound in preparation of herbicide which is safe to wheat and peanuts and is used for preventing and controlling resistant descurainia sophia. Under the dosage of 0.125 g / mu, the compound disclosed by the invention shows a very good weeding effect on descurainia sophia with resistance caused by P197L mutation during stem and leaf treatment. The compound disclosed by the invention also shows good weeding broad-spectrum property. The compounds of the present invention show crop safety to wheat and peanuts at a dose of 2 g / mu. For various strains of wheat, no matter in stem leaf treatment or soil treatment, the compound disclosed by the invention shows good safety under the dosage of 2g / mu.

A sulfonylurea compound and use thereof. The sulfonylurea compound is represented by formula (I), wherein the definition of each substituent is described in detail in the specification. The sulfonylurea compound, as an NLRP3 inhibitor, can be used for preparing a drug for treating diseases related to NLRP3 activity.

The present application relates to a kind of benzene ring alkoxy substitution sulfonylurea compound and its purposes in preparation herbicide.The compound of the present application has good prevention and removal effect on barnyard grass, elephant's ear grass, green bristlegrass, Japanese green bristlegrass, crabgrass, rape and amaranthus in 1 g / m2 dosage, soil treatment or stem-leaf treatment, and has good crop safety to wheat and rice in 2 g / m2 dosage, stem-leaf treatment or soil treatment.The compound can be used as selective herbicide in wheat field and rice field, and can also be used as herbicide in non-crop field such as forest or wasteland.The chemical structural formula of the benzene ring alkoxy substitution sulfonylurea compound is as follows:

Methods of treatment using a compound of formula (I) in combination with a GLP-1 receptor agonist, metformin, a PPAR [gamma] agonist, a sulfonylurea compound, a DPP-IV inhibitor, acarbose or pramlintide or one or more amino acids, one or more vitamins or one or more hormones, or methods of treatment using a compound of formula (I) as an aid thereof, are described.