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Slow release type testis prosthesis and its application

A testicular prosthesis, slow-release technology, applied in the field of prosthesis, can solve the problem of lack of silicone rubber

Inactive Publication Date: 2008-10-08
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. No carcinogenicity: as a biological prosthesis material, silicone rubber has been used clinically for more than 40 years, and its entire history as a medical biomaterial has been more than half a century, but so far there is no exact correlation between silicone rubber and carcinogenicity report
However, there is currently no testicular prosthesis on the market that can release androgen and meet the mental health needs of patients

Method used

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  • Slow release type testis prosthesis and its application
  • Slow release type testis prosthesis and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Slow-release testicular prosthesis preparation

[0035] 1. Drugs and preparations:

[0036] 1. Androgen: Testosterone API (supplied by Zhejiang Xianju API Factory).

[0037] 2. Silicone rubber compound: purchased from Shanghai Rubber Products Research Institute. The silicone rubber used in the present invention is a two-component room temperature vulcanized silicone rubber. Before vulcanization, there are two components, A and B. Among them, the A component contains a catalyst, and the B component contains a crosslinking agent. They do not react with each other, and after blending with each other, the polymerization reaction can be carried out because the catalyst and the crosslinking agent are mixed together.

[0038] 2. Equipment

[0039] 1. Pressure forming machine:

[0040] Product model: XLB-D400-400

[0041]Working fluid pressure: 19.6MPa

[0042] Total pressure: 500kN

[0043] Maximum stroke: 250mm

[0044] Manufacturer: Manufactured by Zhejiang Huzhou Do...

Embodiment 2

[0096] Slow-release testicular prosthesis preparation

[0097] 1. Drugs and preparations:

[0098] 1. Androgen: Testosterone API (supplied by Zhejiang Xianju API Factory).

[0099] 2. Silicone rubber compound: purchased from Shanghai Rubber Products Research Institute. The silicone rubber used in the present invention is a two-component room temperature vulcanized silicone rubber. Before vulcanization, there are two components, A and B. Among them, the A component contains a catalyst, and the B component contains a crosslinking agent. They do not react with each other, and after blending with each other, the polymerization reaction can be carried out because the catalyst and the crosslinking agent are mixed together.

[0100] 2. Equipment

[0101] With the equipment of embodiment 1

[0102] 3. Silicone prosthesis preparation:

[0103] 1. Mold design: Half mold is designed according to the shape of an elliptical rotating body (olive-shaped sphere) with the long diameter as...

Embodiment 3

[0112] Slow-release testicular prosthesis preparation

[0113] 1. Drugs and preparations:

[0114] 1. Androgen: Testosterone API (supplied by Zhejiang Xianju API Factory).

[0115] 2. Silicone rubber compound: purchased from Shanghai Rubber Products Research Institute. The silicone rubber used in the present invention is a two-component room temperature vulcanized silicone rubber. Before vulcanization, there are two components, A and B. Among them, the A component contains a catalyst, and the B component contains a crosslinking agent. They do not react with each other, and after blending with each other, the polymerization reaction can be carried out because the catalyst and the crosslinking agent are mixed together.

[0116] 2. Equipment

[0117] With the equipment of embodiment 1

[0118] 3. Silicone prosthesis preparation:

[0119] 1. Mold design: Half mold is designed according to the shape of an elliptical rotating body (olive-shaped sphere) with the long diameter as...

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Abstract

A slow-release artificial testis for slowly releasing androgen is prepared from silicon rubber and testosterone in weight ratio of (2-4):1. It can be used to replace human testis for androgen therapy.

Description

technical field [0001] The invention relates to a prosthesis, in particular to a slow-release testicular prosthesis and its application. Background technique [0002] Absence of testicles and orchidectomy are not only the loss of physical organs, but also psychological defects for patients. Many patients will choose or hope to choose exogenous testicular substitutes—testicular prosthesis (pseudo prosthesis). Testis, artificial testis) to make up for this physical and psychological loss, the commonly used testicular prosthesis treatment in clinic, although it is only a plastic replacement of male gonads in appearance, without the physiological function of testis (endocrine and spermatogenesis), but its effect on the patient's mental health cannot be replaced by androgen therapy. [0003] Testicular prosthesis is an artificial product similar to testis in appearance. It has experienced a process from inorganic materials to organic compounds, and from low molecular materials t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/54A61K31/568A61P15/00A61F2/02
Inventor 赵海腾
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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