Methanol solvate of doripenem intermediate and preparation method thereof
A technology of methanol solvate and doripenem, which is applied in the direction of organic chemistry, can solve the problems of refining, purification, and storage difficulties, and achieve the effect of simple and reliable preparation method, good stability, and easy storage
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[0022] The conditions for preparing methanol solvates with different soluble solvents and methanol are listed in Table 1, and the specific operation is as follows: 0.1 g of amorphous powder of Compound I is dissolved in a soluble solvent, and after the solution is dissolved, methanol is continuously added thereto , stirred, methanol solvate was precipitated. Example 13 is the condition for recrystallizing the methanol solvate obtained in Example 12.
[0023] Table 1
[0024] no
Soluble
agent
Dosage
/ ml
insoluble
Dosage
/ ml
stirring temperature
/ °C
Stiring time
/ h
purity
(%)
1
0.1
0.2
15
12
99.1
2
0.1
0.2
15
12
99.3
3
DMF
0.2
Methanol
0.4
15
12
98.1
4
0.2
Methanol
...
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