Pyrazole compound as well as composition and application thereof

Abstract

The invention provides a compound and application of the compound and the pharmaceutically acceptable salt thereof or a stereo isomer or a prodrug molecule thereof in preparing a medicament for treating or preventing metabolic diseases, wherein the compound has the structural characteristic of a general expression I and is used as a novel fat cell type fatty acid binding protein FABP inhibitor. The compound having the structural characteristic of the general expression I can provide a new selection for the clinical prevention and treatment of the following diseases: 1. type II diabetes, 2. hyperglycemia, 3. hypoglycemia tolerance, 4. insulin resistance, 5. adiposity, 6. lipid turbulence, 7. blood-lipoid imbalance, 8. hyperlipaemia, 9. hypertriglyceridemia, 10. hypercholesterolemia, 11. low high-density protein level, 12. overhigh low-density protein level, 13. atherosclerosis and secondary diseases thereof, 14. hemadostenosis, 15. abdominal obesity, 16. a metabolic syndrome and 17. fatty liver.

Description

technical field The invention belongs to the field of chemical medicine, in particular to pyrazole compounds or their pharmaceutically acceptable stereoisomers and prodrug molecules, pharmaceutical compositions containing such compounds and the use of these compounds or compositions in the preparation of medicines application. Background technique Lipids and lipid signaling pathways play an important role in integrating metabolic and inflammatory responses, which in turn affect the pathogenesis of chronic metabolic diseases, including type 2 diabetes, fatty liver, and atherosclerosis. However, its specific role and regulatory mechanism are not clear. Fatty acid binding proteins (fatty acid binding proteins, FABPs) are members of the lipid-binding protein superfamily. They are soluble proteins with a molecular weight of 14-16 kD and strong affinity for saturated and unsaturated long-chain fatty acids. In the cytoplasm of animals and invertebrates. It is an important fatty ...

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However, its specific role and r

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