Novel application of Java brucea fruit oil emulsion injection to anticancer aspect
A technology of javanica javanica oil emulsion and injection, applied in the field of anti-human leukemia
Active Publication Date: 2010-11-10
SHENYANG PHARMA UNIVERSITY
View PDF0 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0005] There is no report on the use of Brucea javanica oil emulsion injectio
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Login to View More
PUM
Login to View More
Abstract
The invention provides novel application of Java brucea fruit oil emulsion injection to the anticancer aspect, in particular to novel application to the anti-leukemia aspect. The invention respectively uses humanized leukemia U937, NB4 and HL-60 cell strains and humanized prostatic carcinoma Du145 cell strains as target cells, and studies the inhabiting effect of the Java brucea fruit oil emulsion injection on the blood system tumor and the urogenital system tumor. The invention discovers that the Java brucea fruit oil emulsion injection has the inhabiting effect on the humanized leukemia HL-60, NB4 and U937cell strains and the humanized prostatic carcinoma Du145 cell strains for the first time, and the inhabiting effect is improved along with the gradual increase of the dosage. In addition, the Java brucea fruit oil emulsion injection can also induce the apoptosis of the humanized leukemia cells, and also has the apoptosis induction effect on the primary dissociated leukemia cells. In addition, the bruceolic oil emulsion injection liquid has low cell toxic effect on peripheral blood lymphocytes of normal persons. The results show that the Java brucea fruit oil emulsion injection has certain potential in the aspect of leukemia treatment, and can provide high-efficiency and low-toxicity medicine for the leukemia treatment.
Description
Technical field [0001] The invention relates to a new use of Brucea javanica oil emulsion injection in anti-cancer, in particular to its use in anti-blood system tumors, urogenital system tumors, especially anti-human leukemia. Background technique [0002] Brucea javanica oil is derived from the mature fruit of Brucea javanica (L) Merr, an evergreen shrub of the bitter wood family or a small tree Brucea javanica (L) Merr. Its anti-cancer active ingredient is the fatty acid of Brucea javanica oil, of which oleic acid accounts for 92.1%. As early as the 1950s, there were reports showing that Brucea Javanica oil has a certain effect on external ear canal papilloma and laryngeal papilloma. In the 1970s, Brucea Javanica injection and Brucea javanica oil intravenous emulsion were found to have good effects on cervical cancer and gastrointestinal cancer. . At present, Brucea javanica oil emulsion injection is mainly used clinically, which is mainly used to treat lung cancer, lung canc...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More
IPC IPC(8): A61K36/185A61K9/107A61P35/00A61K131/00
Inventor 吴春福徐勇猛杨静玉韩飞王立辉王芳张弘牟艳华
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com