New compound methyl brevicate with medical activity
A technology of methyl octanoate and breviscapine, which is applied in the fields of organic active ingredients, organic chemistry, and drug combination, and can solve problems such as poor uniformity of curative effect, difficulty in meeting clinical medical needs, and difficulty in quality control
Active Publication Date: 2011-02-16
YUNNAN BIOVALLEY PHARMA CO LTD
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Problems solved by technology
Most of them are mixtures of multiple compounds. Although these drugs have therapeutic effects, the multiple components will inevitably cause the following problems: poor uniformity of curative effect, difficult quality control, and difficult to control side effects (injections are especially obvious)
The only effective drug for a single compound is breviscapine preparations, which is difficult to meet the complex clinical medical needs
Method used
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Embodiment 1
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Embodiment 3
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Abstract
The invention relates to a new compound with a structural formula (I). The compound can be extracted and separated from the dry complete grass of Erigeron Breviscapus (Vant.) Hand.-Mazz. The compound has the effects of inflammatory reaction resistance, platelet aggregation resistance, thrombus resistance and blood vessel extension and can be used for preparing a medicament for treating a heart cerebrovascular disease. The structural formula (I) is shown in the specification.
Description
technical field The present invention relates to a new compound with anti-inflammatory reaction, anti-platelet aggregation, anti-thrombotic and vasodilator effects, and a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases containing the compound as an active ingredient. Specifically, it is a new compound scutellaria brevicate (Methyl Brevicate) extracted from Erigeron breviscapus, its preparation method and its application in pharmacy. Background technique So far, the incidence of cardiovascular and cerebrovascular diseases represented by coronary heart disease and cerebral apoplexy (stroke) remains high, and its case fatality rate ranks first in the death rate of various human diseases. Finding new and effective drugs for the treatment of cardiovascular and cerebrovascular diseases is a difficult and hot spot that the pharmaceutical and clinical medicine circles are very concerned about. Erigeron breviscapus, also known as breviscapus, is ...
Claims
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IPC IPC(8): A61K31/357C07D493/08A61P29/00A61P9/00A61P7/02A61P9/10
Inventor 杜江林艳和林炎海
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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