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Rhesus monkey retinal degeneration model, and drug screening method thereof

A technology for retinal degeneration and rhesus monkeys, which can be used in pharmaceutical formulations, preparations for in vivo experiments, animal husbandry, etc., and can solve problems such as no primate retinal degeneration model

Active Publication Date: 2011-09-28
WEST CHINA HOSPITAL SICHUAN UNIV +2
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Problems solved by technology

[0003] Non-human primates are very close to humans in terms of spec

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  • Rhesus monkey retinal degeneration model, and drug screening method thereof
  • Rhesus monkey retinal degeneration model, and drug screening method thereof
  • Rhesus monkey retinal degeneration model, and drug screening method thereof

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Abstract

The invention provides a preparation method of a rhesus monkey retinal degeneration model. The method comprises: applying sodium iodate with a dosage of 15 to 75 mg/kg to a rhesus monkey. The invention also provides a method for screening drugs for treating retinal degeneration. According to the invention, for the first time, sodium iodate is applied to the rhesus monkey by intravenous injection for constructing a primate retinal degeneration model, an appropriate molding dosage is selected, and a systemic model assessment system is established.

Description

technical field [0001] The invention relates to a rhesus monkey retinal degeneration animal model, in particular, an animal model prepared by administering sodium iodate to rhesus monkeys. Background technique [0002] Retinal degeneration is one of the major eye diseases that cause blindness at present, and the establishment of a stable animal model is the key to solving related scientific research and clinical problems. The current models of retinal degeneration are mainly aimed at rodents, rabbits, etc., such as: Wang Kai, et al., Sodium iodate-induced transneuron degeneration of rabbit retina and optic nerve, " eye research 》, Volume 26, Issue 7, 2008. Experiments were conducted to observe whether intravenous injection of sodium iodate could induce transneuronal degeneration in the retina and optic nerve of experimental animals. The specific method is: 48 Qingzilan rabbits, 8 of which are the control group. The remaining 40 are intravenously injected with sodium iodate ...

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Application Information

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IPC IPC(8): A61K49/00A01K67/027
Inventor 闫乃红陈伟伟刘旭阳王莉李宏霞曹桂群王云余文瀚刘果王丽君向浩天杨吟
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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