Detection of HLA genotype

A genotype, HLA-B technology for rapid genetics
CN102209791BActive Publication Date: 2014-02-12THE CHINESE UNIVERSITY OF HONG KONG +1
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
THE CHINESE UNIVERSITY OF HONG KONG
Publication Date
2014-02-12

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Abstract

Disclosed is a rapid genetic method for detection of HLA genotype based on the loop-mediated isothermal amplification (LAMP) principles, and in particular, disclosed are a method and a kit for detection of HLA-B*1502 allele based on LAMP principles.
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Description

field of invention

[0001] The invention relates to a rapid genetics method for detecting HLA genotypes based on the principle of loop-mediated isothermal amplification (LAMP). Specifically, the present invention relates to a method or a kit for detecting HLA-B*1502 alleles based on the principle of LAMP. Background of the invention

[0002] Human leukocyte antigen (HLA) is a cell surface molecule that is delicately involved in and plays an important role in the presentation of processed antigenic peptides for T cell activation. HLA is encoded by a gene complex on the short arm of chromosome 6, which constitutes one of the most important immune genetic systems in the body. The HLA gene complex is not only polygenic but also multiallelic, so a high diversity of different HLA proteins can be produced in different individuals. Polymorphisms in this mechanism have been shown to be associated with individual variation in susceptibility to immune-mediated / controlled diseases and ...

Claims

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