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Application of aphanamixoid A in preparing antituberculosis medicament

A technology of anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effect of highlighting substantive features, broad application prospects, and expanding types

Inactive Publication Date: 2013-04-03
何晓涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of aphanamixoid A in preparing antituberculosis medicament
  • Application of aphanamixoid A in preparing antituberculosis medicament
  • Application of aphanamixoid A in preparing antituberculosis medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of compound Aphanamixoid A tablets involved in the present invention:

[0017] Take 20 grams of compound Aphanamixoid A, add 180 grams of conventional excipients for preparing tablets, mix well, and prepare 1,000 tablets with a conventional tablet press.

Embodiment 2

[0018] Example 2: Preparation of the compound Aphanamixoid A capsule of the present invention:

[0019] Take 20 grams of compound Aphanamixoid A, add 180 grams of conventional auxiliary materials for preparing capsules, such as starch, and mix them, then encapsulate them to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental example 1 Determination of the absolute concentration of Aphanamixoid A against BCG (BCG) by solid medium dilution method

[0022] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook 7H9 broth medium, add a small amount of glass beads, tighten the cap of the test tube, grind vigorously on a vortex shaker, and compare it to a standard MacFarland turbidity tube (MacFarland No.1). ) Turbidity, that is, 1 mg / ml Bacille Calmette Guerin (BCG) bacterial suspension.

[0023] Mix Aphanamixoid A with DMSO into a high-concentration stock solution, dilute the stock solution with sterile ultrapure water containing 5% Tween-80 to the required concentration, add the diluted Aphanamixoid A to 4 ml Middlebrook 7H11 agar according to the required dose. Base (the medium has been autoclaved at 121°C for 15 minutes and cooled to 50~55°C), mixed, and made into Aphanamixoid A with concentrations of 6.0 ug / ml, 4.0 ug / ml, 3.0 ug / ml, 2.0 ug / ml, 1.5 ug / ml, 1.0 ug / ...

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PUM

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Abstract

The invention discloses an application of aphanamixoid A in preparing an antituberculosis medicament. Regarding the current situation that the tuberculosis incidence rate and death rate are in a rising trend due to the high incidence rate of current tuberculosis and occurrence of multiple-resistant strain of mycobacterium tuberculosis, the invention discovers that aphanamixoid A has remarkable activity of inhibiting tuberculosis, and has a high application prospect. The application of aphanamixoid A in preparing a medicament for treating tuberculosis belongs to first disclosure, which has prominent substantial characteristics because the frame model belongs to a brand-new frame model, and has unexpectedly strong inhibiting activity to tuberculosis without the possibility of giving any revelation by other compounds, and the prevention and treatment of aphanamixoid A for tuberculosis infection has a remarkable progress.

Description

Technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Aphanamixoid A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has been increasing. According to estimates by the World Health Organization (WHO), the current global population infected with Mycobacterium tuberculosis (MTB) accounts for one third of the world’s population, of which 5-10% The infected person becomes a tuberculosis patient. There are 1.3 million cases of active tuberculosis in my country every year, among which about 600,000 cases are infectious tuberculosis, among which about 600,000 cases are infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs, the treatment of tuberculosis has made an epoch-making change. However, because the treatment and ma...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P31/06
Inventor 何晓涛
Owner 何晓涛
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